Comparison of Doppler ultrasonography and the hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis

Yeun Jong Choi, Soon Koo Baik, Dong Hoon Park, Moon Young Kim, Hyun Soo Kim, Dong Ki Lee, Sang Ok Kwon, Young Ju Kim, Joong Wha Park

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background and Aim: This prospective study aimed to determine whether Doppler ultrasonography can represent the hepatic venous pressure gradient (HVPG) as an assessment of the severity of portal hypertension and the response to terlipressin, which reduces the portal pressure in liver cirrhosis. Methods: The HVPG and the Doppler ultrasonographic parameters, such as the portal venous velocity and the splenic venous velocity, the pulsatility and the resistive index of the hepatic, splenic and renal arteries were measured in 138 patients with liver cirrhosis. The changes in the HVPG and the portal venous velocity after administering terlipressin were evaluated in 43 of the 138 patients. The patients who showed a reduction in the HVPG of more than 20% of the baseline were defined as responders to terlipressin. Results: None of the Doppler ultrasonographic parameters correlated with the HVPG. Both the HVPG (28.0±19.8%) and the portal venous velocity (29.7±13.2%) showed a significant reduction after terlipressin administration. However, the portal venous velocity decreased significantly, not only in the responders (31.0±12.0%) but also in the non-responders (25.2±16.4%). Conclusions: Doppler ultrasonography does not represent the HVPG, and is therefore not suitable for replacing HVPG as a means of assessing the severity of portal hypertension and the response to drugs which reduce the portal pressure in liver cirrhosis.

Original languageEnglish
Pages (from-to)424-429
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume18
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1

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Doppler Ultrasonography
Venous Pressure
Portal Hypertension
Liver Cirrhosis
Liver
Portal Pressure
Splenic Artery
Hepatic Artery
Renal Artery
Prospective Studies
terlipressin

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

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title = "Comparison of Doppler ultrasonography and the hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis",
abstract = "Background and Aim: This prospective study aimed to determine whether Doppler ultrasonography can represent the hepatic venous pressure gradient (HVPG) as an assessment of the severity of portal hypertension and the response to terlipressin, which reduces the portal pressure in liver cirrhosis. Methods: The HVPG and the Doppler ultrasonographic parameters, such as the portal venous velocity and the splenic venous velocity, the pulsatility and the resistive index of the hepatic, splenic and renal arteries were measured in 138 patients with liver cirrhosis. The changes in the HVPG and the portal venous velocity after administering terlipressin were evaluated in 43 of the 138 patients. The patients who showed a reduction in the HVPG of more than 20{\%} of the baseline were defined as responders to terlipressin. Results: None of the Doppler ultrasonographic parameters correlated with the HVPG. Both the HVPG (28.0±19.8{\%}) and the portal venous velocity (29.7±13.2{\%}) showed a significant reduction after terlipressin administration. However, the portal venous velocity decreased significantly, not only in the responders (31.0±12.0{\%}) but also in the non-responders (25.2±16.4{\%}). Conclusions: Doppler ultrasonography does not represent the HVPG, and is therefore not suitable for replacing HVPG as a means of assessing the severity of portal hypertension and the response to drugs which reduce the portal pressure in liver cirrhosis.",
author = "Choi, {Yeun Jong} and Baik, {Soon Koo} and Park, {Dong Hoon} and Kim, {Moon Young} and Kim, {Hyun Soo} and Lee, {Dong Ki} and Kwon, {Sang Ok} and Kim, {Young Ju} and Park, {Joong Wha}",
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Comparison of Doppler ultrasonography and the hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis. / Choi, Yeun Jong; Baik, Soon Koo; Park, Dong Hoon; Kim, Moon Young; Kim, Hyun Soo; Lee, Dong Ki; Kwon, Sang Ok; Kim, Young Ju; Park, Joong Wha.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 18, No. 4, 01.04.2003, p. 424-429.

Research output: Contribution to journalArticle

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T1 - Comparison of Doppler ultrasonography and the hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis

AU - Choi, Yeun Jong

AU - Baik, Soon Koo

AU - Park, Dong Hoon

AU - Kim, Moon Young

AU - Kim, Hyun Soo

AU - Lee, Dong Ki

AU - Kwon, Sang Ok

AU - Kim, Young Ju

AU - Park, Joong Wha

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