Comparison of durable-polymer-and biodegradable-polymer-based newer-generation drug-eluting stents in patients with acute myocardial infarction and prediabetes after successful percutaneous coronary intervention

Yong Hoon Kim, Ae Young Her, Myung Ho Jeong, Byeong Keuk Kim, Sung Jin Hong, Seunghwan Kim, Chul Min Ahn, Jung Sun Kim, Young Guk Ko, Donghoon Choi, Myeongki Hong, Yangsoo Jang

Research output: Contribution to journalArticlepeer-review

Abstract

Hyperglycemia is an important risk factor for poor clinical outcomes in patients with acute myocardial infarction (AMI). The relative superiority of the long-term clinical outcomes of durable-polymer (DP)-based and biodegradable-polymer (BP)-based newer-generation drug-eluting stents (DESs) after successful percutaneous coronary intervention (PCI) in patients with AMI and prediabetes is not well established. We compared the clinical outcomes in such patients between DP-based and BP-based newer-generation DESs. A total of 4,377 patients with AMI and prediabetes were divided into the following two groups: the DPDES group (n = 3,775; zotarolimus-eluting stents [ZES; n = 1,546] and everolimus-eluting stents [EES; n = 2,229]) and the BP-DES group (n = 602; biolimus-eluting stents [BES]). The primary endpoint was the occurrence of major adverse cardiac events (MACEs), defined as all-cause death, recurrent myocardial infarction (reMI), or any repeat revascularization. The secondary endpoint was the occurrence of stent thrombosis (ST). The 2-year adjusted hazard ratio (aHR) of MACEs for ZES versus EES, ZES versus BES, EES versus BES, and ZES/EES versus BES (aHR: 1.125; 95% confidence interval [CI], 0.834-1.518; P = 0.440) were similar. The cumulative incidence of ST was also comparable between the DP-DES and BP-DES groups (aHR: 1.407; 95% CI, 0.476-4.158; P = 0.537). Moreover, the 2-year aHRs of all-cause death, CD, re-MI, target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR were similar. Patients with AMI and prediabetes who received DP-DES or BP-DES during PCI showed comparable safety and efficacy during the 2-year follow-up period.

Original languageEnglish
Pages (from-to)673-684
Number of pages12
JournalInternational Heart Journal
Volume61
Issue number4
DOIs
Publication statusPublished - 2020

Bibliographical note

Funding Information:
We would like to acknowledge and thank contributions of all participating Korea Acute Myocardial Infarction Registry (KAMIR) investigators.

Publisher Copyright:
© 2020, International Heart Journal Association. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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