TY - JOUR
T1 - Comparison of effects of drug-eluting stents versus bare metal stents on plasma C-reactive protein levels
AU - Kim, Jong Youn
AU - Ko, Young Guk
AU - Chi, Young Shim
AU - Park, Sungha
AU - Hwang, Ki Chul
AU - Choi, Donghoon
AU - Jang, Yangsoo
AU - Chung, Namsik
AU - Shim, Won Heum
AU - Cho, Seung Yun
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/11/15
Y1 - 2005/11/15
N2 - After coronary stenting, inflammatory mechanisms play a crucial role in the pathogenesis of neointimal proliferation and in-stent restenosis. Drug-eluting stents (DESs) have been shown to decrease in-stent restenosis in different studies. We compared plasma C-reactive protein (CRP) levels after DES implantation with levels after bare metal stent (BMS) implantation. We performed percutaneous coronary intervention with a single stent in 67 patients (54 men; 59 ± 9 years of age; n = 21 in the BMS group, n = 46 in the DES group) who had stable angina. Plasma CRP levels were determined before intervention and at 48 hours, 72 hours, and 2 weeks after coronary stenting. There was no difference in clinical and angiographic baseline characteristics except that the DES group had more patients with diabetes (34.8% vs 9.5%, p = 0.04), smaller reference vessels (2.95 ± 0.53 vs 3.29 ± 0.53 mm, p = 0.02), and smaller stent diameters (3.0 ± 0.4 mm vs 3.4 ± 0.5 mm, p <0.01). Plasma CRP levels at 48 hours (13.4 ± 14.7 vs 5.9 ± 4.9 mg/L, p <0.01) and 72 hours (16.7 ± 19.8 vs 5.4 ± 3.9 mg/L, p <0.01) after stent implantation were significantly higher in the BMS than in the DES group. In conclusion, DESs showed significantly lower plasma CRP levels after coronary stenting compared with BMSs. This may reflect the potent effects of DESs on acute inflammatory reactions induced by coronary intervention.
AB - After coronary stenting, inflammatory mechanisms play a crucial role in the pathogenesis of neointimal proliferation and in-stent restenosis. Drug-eluting stents (DESs) have been shown to decrease in-stent restenosis in different studies. We compared plasma C-reactive protein (CRP) levels after DES implantation with levels after bare metal stent (BMS) implantation. We performed percutaneous coronary intervention with a single stent in 67 patients (54 men; 59 ± 9 years of age; n = 21 in the BMS group, n = 46 in the DES group) who had stable angina. Plasma CRP levels were determined before intervention and at 48 hours, 72 hours, and 2 weeks after coronary stenting. There was no difference in clinical and angiographic baseline characteristics except that the DES group had more patients with diabetes (34.8% vs 9.5%, p = 0.04), smaller reference vessels (2.95 ± 0.53 vs 3.29 ± 0.53 mm, p = 0.02), and smaller stent diameters (3.0 ± 0.4 mm vs 3.4 ± 0.5 mm, p <0.01). Plasma CRP levels at 48 hours (13.4 ± 14.7 vs 5.9 ± 4.9 mg/L, p <0.01) and 72 hours (16.7 ± 19.8 vs 5.4 ± 3.9 mg/L, p <0.01) after stent implantation were significantly higher in the BMS than in the DES group. In conclusion, DESs showed significantly lower plasma CRP levels after coronary stenting compared with BMSs. This may reflect the potent effects of DESs on acute inflammatory reactions induced by coronary intervention.
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U2 - 10.1016/j.amjcard.2005.07.042
DO - 10.1016/j.amjcard.2005.07.042
M3 - Article
C2 - 16275183
AN - SCOPUS:27644517317
VL - 96
SP - 1384
EP - 1388
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 10
ER -