Background: Declining of eradication rates for Helicobacter pylori in Korea may be partly from the increasing prevalence of antibiotic resistance, especially clarithromycin resistance. Aim: To compare the efficacy and the safety of using 10-day standard sequential therapy and levofloxacin-containing sequential therapy as a first-line treatment for Helicobacter pylori eradication in Korea. Methods: A total of 200 patients with proven Helicobacter pylori infection randomly received 10-day standard sequential therapy (n= 100) or levofloxacin-containing sequential therapy (n= 100). The standard sequential therapy group received rabeprazole and amoxicillin for 5 days, followed by rabeprazole, clarithromycin, and metronidazole for 5 more days. The levofloxacin-containing sequential therapy group was treated with rabeprazole and amoxicillin for 5 days, followed by rabeprazole, levofloxacin, and metronidazole for 5 more days. Results: Intention-to-treat eradication rates were 79.0% and 78.0% for groups of standard sequential and levofloxacin-containing sequential therapy, respectively (P= 0.863). Per-protocol eradication rates were 84.9% and 81.3%, respectively, for these two therapies (P= 0.498). There were no significant differences between the groups in regard to the eradication rates and adverse events. Conclusions: The 10-day levofloxacin-containing sequential regimen and the standard sequential regimen showed the similar eradication rates of Helicobacter pylori in Korea.
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