Comparison of efficacy of cefoperazone/sulbactam and imipenem/cilastatin for treatment of acinetobacter bacteremia

Jun Yong Choi, Chang Oh Kim, Yoon Seon Park, Hee Jung Yoon, So Youn Shin, Young Keun Kim, Myung Soo Kim, Yeon A. Kim, Young Goo Song, Dongeun Yong, Kyungwon Lee, June Myung Kim

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Multiple antibiotic reisistance threatens successful treatment of Acinetobacter baumannii infections worldwide. Increasing interest in the well-known activity of sulbactam against the genus Acinetobacter has been aroused. The purpose of this study was to compare the outcomes for patients with Acinetobacter bacteremia treated with cefoperazone/sulbactam versus imipenem/cilastatin. Forty-seven patients with Acinetobacter baumannii bacteremia were analyzed through a retrospective review of their medical records for antibiotic therapy and clinical outcome. Thirty-five patients were treated with cefoperazone/sulbactam, and twelve patients with imipenem/cilastatin. The percentage of favorable response after 72 hours was not statistically different between cefoperazone/ sulbactam group and imipenem/ cilastatin group. The mortality rate was not statistically different, too. Cefoperazone/sulbactam was found to be as useful as imipenem/cilastatin for treating patients with Acinetobacter bacteremia.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalYonsei medical journal
Volume47
Issue number1
DOIs
Publication statusPublished - 2006 Feb 6

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Cefoperazone
Sulbactam
Acinetobacter
Bacteremia
Acinetobacter baumannii
Acinetobacter Infections
Anti-Bacterial Agents
Therapeutics
Medical Records
imipenem drug combination cilastatin
Mortality

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Choi, Jun Yong ; Kim, Chang Oh ; Park, Yoon Seon ; Yoon, Hee Jung ; Shin, So Youn ; Kim, Young Keun ; Kim, Myung Soo ; Kim, Yeon A. ; Song, Young Goo ; Yong, Dongeun ; Lee, Kyungwon ; Kim, June Myung. / Comparison of efficacy of cefoperazone/sulbactam and imipenem/cilastatin for treatment of acinetobacter bacteremia. In: Yonsei medical journal. 2006 ; Vol. 47, No. 1. pp. 63-69.
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Comparison of efficacy of cefoperazone/sulbactam and imipenem/cilastatin for treatment of acinetobacter bacteremia. / Choi, Jun Yong; Kim, Chang Oh; Park, Yoon Seon; Yoon, Hee Jung; Shin, So Youn; Kim, Young Keun; Kim, Myung Soo; Kim, Yeon A.; Song, Young Goo; Yong, Dongeun; Lee, Kyungwon; Kim, June Myung.

In: Yonsei medical journal, Vol. 47, No. 1, 06.02.2006, p. 63-69.

Research output: Contribution to journalReview article

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AU - Choi, Jun Yong

AU - Kim, Chang Oh

AU - Park, Yoon Seon

AU - Yoon, Hee Jung

AU - Shin, So Youn

AU - Kim, Young Keun

AU - Kim, Myung Soo

AU - Kim, Yeon A.

AU - Song, Young Goo

AU - Yong, Dongeun

AU - Lee, Kyungwon

AU - Kim, June Myung

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