Comparison of efficacy of cefoperazone/sulbactam and imipenem/cilastatin for treatment of acinetobacter bacteremia

Jun Yong Choi, Chang Oh Kim, Yoon Seon Park, Hee Jung Yoon, So Youn Shin, Young Keun Kim, Myung Soo Kim, Yeon A. Kim, Young Goo Song, Dongeun Yong, Kyungwon Lee, June Myung Kim

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26 Citations (Scopus)

Abstract

Multiple antibiotic reisistance threatens successful treatment of Acinetobacter baumannii infections worldwide. Increasing interest in the well-known activity of sulbactam against the genus Acinetobacter has been aroused. The purpose of this study was to compare the outcomes for patients with Acinetobacter bacteremia treated with cefoperazone/sulbactam versus imipenem/cilastatin. Forty-seven patients with Acinetobacter baumannii bacteremia were analyzed through a retrospective review of their medical records for antibiotic therapy and clinical outcome. Thirty-five patients were treated with cefoperazone/sulbactam, and twelve patients with imipenem/cilastatin. The percentage of favorable response after 72 hours was not statistically different between cefoperazone/ sulbactam group and imipenem/ cilastatin group. The mortality rate was not statistically different, too. Cefoperazone/sulbactam was found to be as useful as imipenem/cilastatin for treating patients with Acinetobacter bacteremia.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalYonsei medical journal
Volume47
Issue number1
DOIs
Publication statusPublished - 2006 Feb 6

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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