Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

Bum Sik Chin; Jun Yong Choi; Yang Han; Jiqiu Kuang; Yanling Li; Sang Hoon Han; Heekyoung Choi; Yun Tae Chae; Sung Joon Jin; Ji Hyeon Baek; Young Soun Lim; Chang Oh Kim; Young Goo Song; Dongeun Yong; Taisheng Li; June Myung Kim

doi:10.1089/aid.2009.0157

Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

Bum Sik Chin, Jun Yong Choi, Yang Han, Jiqiu Kuang, Yanling Li, Sang Hoon Han, Heekyoung Choi, Yun Tae Chae, Sung Joon Jin, Ji Hyeon Baek, Young Soun Lim, Chang Oh Kim, Young Goo Song, Dongeun Yong, Taisheng Li, June Myung Kim

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Abstract

Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p<0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.

Original language	English
Pages (from-to)	217-221
Number of pages	5
Journal	AIDS Research and Human Retroviruses
Volume	26
Issue number	2
DOIs	https://doi.org/10.1089/aid.2009.0157
Publication status	Published - 2010 Feb 1

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/aid.2009.0157

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Chin, B. S., Choi, J. Y., Han, Y., Kuang, J., Li, Y., Han, S. H., Choi, H., Chae, Y. T., Jin, S. J., Baek, J. H., Lim, Y. S., Kim, C. O., Song, Y. G., Yong, D., Li, T., & Kim, J. M. (2010). Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China. AIDS Research and Human Retroviruses, 26(2), 217-221. https://doi.org/10.1089/aid.2009.0157

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title = "Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China",

abstract = "Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p<0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.",

author = "Chin, {Bum Sik} and Choi, {Jun Yong} and Yang Han and Jiqiu Kuang and Yanling Li and Han, {Sang Hoon} and Heekyoung Choi and Chae, {Yun Tae} and Jin, {Sung Joon} and Baek, {Ji Hyeon} and Lim, {Young Soun} and Kim, {Chang Oh} and Song, {Young Goo} and Dongeun Yong and Taisheng Li and Kim, {June Myung}",

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doi = "10.1089/aid.2009.0157",

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Chin, BS, Choi, JY, Han, Y, Kuang, J, Li, Y, Han, SH, Choi, H, Chae, YT, Jin, SJ, Baek, JH, Lim, YS, Kim, CO, Song, YG, Yong, D, Li, T & Kim, JM 2010, 'Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China', AIDS Research and Human Retroviruses, vol. 26, no. 2, pp. 217-221. https://doi.org/10.1089/aid.2009.0157

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T1 - Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

AU - Chin, Bum Sik

AU - Choi, Jun Yong

AU - Han, Yang

AU - Kuang, Jiqiu

AU - Li, Yanling

AU - Han, Sang Hoon

AU - Choi, Heekyoung

AU - Chae, Yun Tae

AU - Jin, Sung Joon

AU - Baek, Ji Hyeon

AU - Lim, Young Soun

AU - Kim, Chang Oh

AU - Song, Young Goo

AU - Yong, Dongeun

AU - Li, Taisheng

AU - Kim, June Myung

PY - 2010/2/1

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N2 - Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p<0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.

AB - Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p<0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.

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Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

Abstract

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