Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

Bum Sik Chin, JunYong Choi, Yang Han, Jiqiu Kuang, Yanling Li, Sang Hoon Han, Heekyoung Choi, Yun Tae Chae, Sung Joon Jin, Ji Hyeon Baek, Young Soun Lim, Chang Oh Kim, Young Goo Song, DongEun Yong, Taisheng Li, June Myung Kim

Research output: Contribution to journalArticle

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Abstract

Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p<0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume26
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

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Korea
Drug Resistance
HIV-1
China
Mutation
RNA-Directed DNA Polymerase
Population
Cluster Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Chin, Bum Sik ; Choi, JunYong ; Han, Yang ; Kuang, Jiqiu ; Li, Yanling ; Han, Sang Hoon ; Choi, Heekyoung ; Chae, Yun Tae ; Jin, Sung Joon ; Baek, Ji Hyeon ; Lim, Young Soun ; Kim, Chang Oh ; Song, Young Goo ; Yong, DongEun ; Li, Taisheng ; Kim, June Myung. / Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China. In: AIDS Research and Human Retroviruses. 2010 ; Vol. 26, No. 2. pp. 217-221.
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abstract = "Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2{\%}, V179D 7.9{\%}). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6{\%} vs. 0{\%}, 45.5{\%} vs. 12.5{\%}, p<0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.",
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Chin, BS, Choi, J, Han, Y, Kuang, J, Li, Y, Han, SH, Choi, H, Chae, YT, Jin, SJ, Baek, JH, Lim, YS, Kim, CO, Song, YG, Yong, D, Li, T & Kim, JM 2010, 'Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China', AIDS Research and Human Retroviruses, vol. 26, no. 2, pp. 217-221. https://doi.org/10.1089/aid.2009.0157

Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China. / Chin, Bum Sik; Choi, JunYong; Han, Yang; Kuang, Jiqiu; Li, Yanling; Han, Sang Hoon; Choi, Heekyoung; Chae, Yun Tae; Jin, Sung Joon; Baek, Ji Hyeon; Lim, Young Soun; Kim, Chang Oh; Song, Young Goo; Yong, DongEun; Li, Taisheng; Kim, June Myung.

In: AIDS Research and Human Retroviruses, Vol. 26, No. 2, 01.02.2010, p. 217-221.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

AU - Chin, Bum Sik

AU - Choi, JunYong

AU - Han, Yang

AU - Kuang, Jiqiu

AU - Li, Yanling

AU - Han, Sang Hoon

AU - Choi, Heekyoung

AU - Chae, Yun Tae

AU - Jin, Sung Joon

AU - Baek, Ji Hyeon

AU - Lim, Young Soun

AU - Kim, Chang Oh

AU - Song, Young Goo

AU - Yong, DongEun

AU - Li, Taisheng

AU - Kim, June Myung

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AB - Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p<0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.

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