Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China

Bum Sik Chin, Jun Yong Choi, Yang Han, Jiqiu Kuang, Yanling Li, Sang Hoon Han, Heekyoung Choi, Yun Tae Chae, Sung Joon Jin, Ji Hyeon Baek, Young Soun Lim, Chang Oh Kim, Young Goo Song, Dongeun Yong, Taisheng Li, June Myung Kim

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Abstract

Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p<0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume26
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

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    Chin, B. S., Choi, J. Y., Han, Y., Kuang, J., Li, Y., Han, S. H., Choi, H., Chae, Y. T., Jin, S. J., Baek, J. H., Lim, Y. S., Kim, C. O., Song, Y. G., Yong, D., Li, T., & Kim, J. M. (2010). Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China. AIDS Research and Human Retroviruses, 26(2), 217-221. https://doi.org/10.1089/aid.2009.0157