Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis

Won Jung Koh, Seung Heon Lee, youngae kang, Chang Hoon Lee, Jae Chol Choi, Jae Ho Lee, Seung Hun Jang, Kwang Ha Yoo, Ki Hwan Jung, Ki Uk Kim, Sang Bong Choi, Yon Ju Ryu, Kyung Chan Kim, Soojung Um, Yong Soo Kwon, Yee Hyung Kim, Won Il Choi, Kyeongman Jeon, Yong Il Hwang, Se Joong Kim & 6 others Young Seok Lee, Eun Young Heo, Juhee Lee, Yeo WoonKi, Tae Sun Shim, Jae Joon Yim

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Measurements and Main Results: At 3 months of treatment, 68 (88.3%) of the 77 patients in the LFX group and 67 (90.5%) of the 74 in theMXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95% confidence interval, 0.27-2.20). Adverse drug reactions were reported in six patients (7.7%) in the LFX group and four (5.2%) in theMXF group (P = 0.75). Conclusions:ThechoiceofLFXorMXFfortreatmentofpatientswithMDRTB may not affect sputum culture conversion at 3 months of treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).

Original languageEnglish
Pages (from-to)858-864
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume188
Issue number7
DOIs
Publication statusPublished - 2013 Oct 1

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Multidrug-Resistant Tuberculosis
Levofloxacin
Sputum
Drug-Related Side Effects and Adverse Reactions
Odds Ratio
Clinical Trials
Confidence Intervals
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Koh, Won Jung ; Lee, Seung Heon ; kang, youngae ; Lee, Chang Hoon ; Choi, Jae Chol ; Lee, Jae Ho ; Jang, Seung Hun ; Yoo, Kwang Ha ; Jung, Ki Hwan ; Kim, Ki Uk ; Choi, Sang Bong ; Ryu, Yon Ju ; Kim, Kyung Chan ; Um, Soojung ; Kwon, Yong Soo ; Kim, Yee Hyung ; Choi, Won Il ; Jeon, Kyeongman ; Hwang, Yong Il ; Kim, Se Joong ; Lee, Young Seok ; Heo, Eun Young ; Lee, Juhee ; WoonKi, Yeo ; Shim, Tae Sun ; Yim, Jae Joon. / Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis. In: American Journal of Respiratory and Critical Care Medicine. 2013 ; Vol. 188, No. 7. pp. 858-864.
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abstract = "Measurements and Main Results: At 3 months of treatment, 68 (88.3{\%}) of the 77 patients in the LFX group and 67 (90.5{\%}) of the 74 in theMXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95{\%} confidence interval, 0.27-2.20). Adverse drug reactions were reported in six patients (7.7{\%}) in the LFX group and four (5.2{\%}) in theMXF group (P = 0.75). Conclusions:ThechoiceofLFXorMXFfortreatmentofpatientswithMDRTB may not affect sputum culture conversion at 3 months of treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).",
author = "Koh, {Won Jung} and Lee, {Seung Heon} and youngae kang and Lee, {Chang Hoon} and Choi, {Jae Chol} and Lee, {Jae Ho} and Jang, {Seung Hun} and Yoo, {Kwang Ha} and Jung, {Ki Hwan} and Kim, {Ki Uk} and Choi, {Sang Bong} and Ryu, {Yon Ju} and Kim, {Kyung Chan} and Soojung Um and Kwon, {Yong Soo} and Kim, {Yee Hyung} and Choi, {Won Il} and Kyeongman Jeon and Hwang, {Yong Il} and Kim, {Se Joong} and Lee, {Young Seok} and Heo, {Eun Young} and Juhee Lee and Yeo WoonKi and Shim, {Tae Sun} and Yim, {Jae Joon}",
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Koh, WJ, Lee, SH, kang, Y, Lee, CH, Choi, JC, Lee, JH, Jang, SH, Yoo, KH, Jung, KH, Kim, KU, Choi, SB, Ryu, YJ, Kim, KC, Um, S, Kwon, YS, Kim, YH, Choi, WI, Jeon, K, Hwang, YI, Kim, SJ, Lee, YS, Heo, EY, Lee, J, WoonKi, Y, Shim, TS & Yim, JJ 2013, 'Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis', American Journal of Respiratory and Critical Care Medicine, vol. 188, no. 7, pp. 858-864. https://doi.org/10.1164/rccm.201303-0604OC

Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis. / Koh, Won Jung; Lee, Seung Heon; kang, youngae; Lee, Chang Hoon; Choi, Jae Chol; Lee, Jae Ho; Jang, Seung Hun; Yoo, Kwang Ha; Jung, Ki Hwan; Kim, Ki Uk; Choi, Sang Bong; Ryu, Yon Ju; Kim, Kyung Chan; Um, Soojung; Kwon, Yong Soo; Kim, Yee Hyung; Choi, Won Il; Jeon, Kyeongman; Hwang, Yong Il; Kim, Se Joong; Lee, Young Seok; Heo, Eun Young; Lee, Juhee; WoonKi, Yeo; Shim, Tae Sun; Yim, Jae Joon.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 188, No. 7, 01.10.2013, p. 858-864.

Research output: Contribution to journalArticle

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T1 - Comparison of levofloxacin versusmoxifloxacin for multidrug-resistant tuberculosis

AU - Koh, Won Jung

AU - Lee, Seung Heon

AU - kang, youngae

AU - Lee, Chang Hoon

AU - Choi, Jae Chol

AU - Lee, Jae Ho

AU - Jang, Seung Hun

AU - Yoo, Kwang Ha

AU - Jung, Ki Hwan

AU - Kim, Ki Uk

AU - Choi, Sang Bong

AU - Ryu, Yon Ju

AU - Kim, Kyung Chan

AU - Um, Soojung

AU - Kwon, Yong Soo

AU - Kim, Yee Hyung

AU - Choi, Won Il

AU - Jeon, Kyeongman

AU - Hwang, Yong Il

AU - Kim, Se Joong

AU - Lee, Young Seok

AU - Heo, Eun Young

AU - Lee, Juhee

AU - WoonKi, Yeo

AU - Shim, Tae Sun

AU - Yim, Jae Joon

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Measurements and Main Results: At 3 months of treatment, 68 (88.3%) of the 77 patients in the LFX group and 67 (90.5%) of the 74 in theMXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95% confidence interval, 0.27-2.20). Adverse drug reactions were reported in six patients (7.7%) in the LFX group and four (5.2%) in theMXF group (P = 0.75). Conclusions:ThechoiceofLFXorMXFfortreatmentofpatientswithMDRTB may not affect sputum culture conversion at 3 months of treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).

AB - Measurements and Main Results: At 3 months of treatment, 68 (88.3%) of the 77 patients in the LFX group and 67 (90.5%) of the 74 in theMXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95% confidence interval, 0.27-2.20). Adverse drug reactions were reported in six patients (7.7%) in the LFX group and four (5.2%) in theMXF group (P = 0.75). Conclusions:ThechoiceofLFXorMXFfortreatmentofpatientswithMDRTB may not affect sputum culture conversion at 3 months of treatment. Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).

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