Comparison of long-term clinical outcomes between endoscopic and surgical resection for early-stage adenocarcinoma of the esophagogastric junction

Hyun Ju Kim, Hyunsoo Chung, Sung Kwan Shin, Hyoung Il Kim, Jun Chul Park, Sang Kil Lee, Woo Jin Hyung, Yong Chan Lee, Sung Hoon Noh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The aim of this study was to analyze long-term clinical and oncologic outcomes in patients with early-stage adenocarcinoma of the esophagogastric junction (AEG) managed with either endoscopic resection (ER) or surgery. Methods: The inclusion criteria were AEG, meeting classic or expanded indications for ER of early gastric cancer, and complete resection. A total of 66 patients with Siewert type II AEG were included (ER group, n = 38; vs. surgery group, n = 28). Results: The mean age of the ER group was greater than that of the surgery group (mean ± SD, 66.9 ± 9.7 vs. 58.5 ± 10.4 years, respectively; p = 0.001). Compared to the ER group, macroscopically flat or depressed-type lesions were more common (47.4 vs. 89.3%; p = 0.001), and mean lesion size was larger in the surgery group (13.3 ± 8.4 vs. 18.6 ± 11.0 mm; p = 0.039). One intensive care unit admission and subsequent surgery-related death occurred in the surgery group (1/28 vs. 0/38 in the ER group; p = 0.424). During follow-up, recurrence was detected in both groups (4/38 vs. 1/28; p = 0.385). Overall survival and 5-year disease-free survival did not differ between the groups (93.3 vs. 92.9%; p = 0.282 and 88.0 vs. 100.0%; p = 0.066). Conclusions: Once complete resection is achieved in patients with AEG who met the expanded criteria for endoscopic submucosal dissection of gastric cancer, there was no significant difference in clinical outcomes between ER and surgery.

Original languageEnglish
Pages (from-to)3540-3547
Number of pages8
JournalSurgical endoscopy
Volume32
Issue number8
DOIs
Publication statusPublished - 2018 Aug 1

Fingerprint

Esophagogastric Junction
Adenocarcinoma
Stomach Neoplasms
Disease-Free Survival
Intensive Care Units
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Kim, Hyun Ju ; Chung, Hyunsoo ; Shin, Sung Kwan ; Kim, Hyoung Il ; Park, Jun Chul ; Lee, Sang Kil ; Hyung, Woo Jin ; Lee, Yong Chan ; Noh, Sung Hoon. / Comparison of long-term clinical outcomes between endoscopic and surgical resection for early-stage adenocarcinoma of the esophagogastric junction. In: Surgical endoscopy. 2018 ; Vol. 32, No. 8. pp. 3540-3547.
@article{1aacc358aaa64f62849b934bf58e2896,
title = "Comparison of long-term clinical outcomes between endoscopic and surgical resection for early-stage adenocarcinoma of the esophagogastric junction",
abstract = "Background: The aim of this study was to analyze long-term clinical and oncologic outcomes in patients with early-stage adenocarcinoma of the esophagogastric junction (AEG) managed with either endoscopic resection (ER) or surgery. Methods: The inclusion criteria were AEG, meeting classic or expanded indications for ER of early gastric cancer, and complete resection. A total of 66 patients with Siewert type II AEG were included (ER group, n = 38; vs. surgery group, n = 28). Results: The mean age of the ER group was greater than that of the surgery group (mean ± SD, 66.9 ± 9.7 vs. 58.5 ± 10.4 years, respectively; p = 0.001). Compared to the ER group, macroscopically flat or depressed-type lesions were more common (47.4 vs. 89.3{\%}; p = 0.001), and mean lesion size was larger in the surgery group (13.3 ± 8.4 vs. 18.6 ± 11.0 mm; p = 0.039). One intensive care unit admission and subsequent surgery-related death occurred in the surgery group (1/28 vs. 0/38 in the ER group; p = 0.424). During follow-up, recurrence was detected in both groups (4/38 vs. 1/28; p = 0.385). Overall survival and 5-year disease-free survival did not differ between the groups (93.3 vs. 92.9{\%}; p = 0.282 and 88.0 vs. 100.0{\%}; p = 0.066). Conclusions: Once complete resection is achieved in patients with AEG who met the expanded criteria for endoscopic submucosal dissection of gastric cancer, there was no significant difference in clinical outcomes between ER and surgery.",
author = "Kim, {Hyun Ju} and Hyunsoo Chung and Shin, {Sung Kwan} and Kim, {Hyoung Il} and Park, {Jun Chul} and Lee, {Sang Kil} and Hyung, {Woo Jin} and Lee, {Yong Chan} and Noh, {Sung Hoon}",
year = "2018",
month = "8",
day = "1",
doi = "10.1007/s00464-018-6076-5",
language = "English",
volume = "32",
pages = "3540--3547",
journal = "Surgical Endoscopy",
issn = "0930-2794",
publisher = "Springer New York",
number = "8",

}

Comparison of long-term clinical outcomes between endoscopic and surgical resection for early-stage adenocarcinoma of the esophagogastric junction. / Kim, Hyun Ju; Chung, Hyunsoo; Shin, Sung Kwan; Kim, Hyoung Il; Park, Jun Chul; Lee, Sang Kil; Hyung, Woo Jin; Lee, Yong Chan; Noh, Sung Hoon.

In: Surgical endoscopy, Vol. 32, No. 8, 01.08.2018, p. 3540-3547.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of long-term clinical outcomes between endoscopic and surgical resection for early-stage adenocarcinoma of the esophagogastric junction

AU - Kim, Hyun Ju

AU - Chung, Hyunsoo

AU - Shin, Sung Kwan

AU - Kim, Hyoung Il

AU - Park, Jun Chul

AU - Lee, Sang Kil

AU - Hyung, Woo Jin

AU - Lee, Yong Chan

AU - Noh, Sung Hoon

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background: The aim of this study was to analyze long-term clinical and oncologic outcomes in patients with early-stage adenocarcinoma of the esophagogastric junction (AEG) managed with either endoscopic resection (ER) or surgery. Methods: The inclusion criteria were AEG, meeting classic or expanded indications for ER of early gastric cancer, and complete resection. A total of 66 patients with Siewert type II AEG were included (ER group, n = 38; vs. surgery group, n = 28). Results: The mean age of the ER group was greater than that of the surgery group (mean ± SD, 66.9 ± 9.7 vs. 58.5 ± 10.4 years, respectively; p = 0.001). Compared to the ER group, macroscopically flat or depressed-type lesions were more common (47.4 vs. 89.3%; p = 0.001), and mean lesion size was larger in the surgery group (13.3 ± 8.4 vs. 18.6 ± 11.0 mm; p = 0.039). One intensive care unit admission and subsequent surgery-related death occurred in the surgery group (1/28 vs. 0/38 in the ER group; p = 0.424). During follow-up, recurrence was detected in both groups (4/38 vs. 1/28; p = 0.385). Overall survival and 5-year disease-free survival did not differ between the groups (93.3 vs. 92.9%; p = 0.282 and 88.0 vs. 100.0%; p = 0.066). Conclusions: Once complete resection is achieved in patients with AEG who met the expanded criteria for endoscopic submucosal dissection of gastric cancer, there was no significant difference in clinical outcomes between ER and surgery.

AB - Background: The aim of this study was to analyze long-term clinical and oncologic outcomes in patients with early-stage adenocarcinoma of the esophagogastric junction (AEG) managed with either endoscopic resection (ER) or surgery. Methods: The inclusion criteria were AEG, meeting classic or expanded indications for ER of early gastric cancer, and complete resection. A total of 66 patients with Siewert type II AEG were included (ER group, n = 38; vs. surgery group, n = 28). Results: The mean age of the ER group was greater than that of the surgery group (mean ± SD, 66.9 ± 9.7 vs. 58.5 ± 10.4 years, respectively; p = 0.001). Compared to the ER group, macroscopically flat or depressed-type lesions were more common (47.4 vs. 89.3%; p = 0.001), and mean lesion size was larger in the surgery group (13.3 ± 8.4 vs. 18.6 ± 11.0 mm; p = 0.039). One intensive care unit admission and subsequent surgery-related death occurred in the surgery group (1/28 vs. 0/38 in the ER group; p = 0.424). During follow-up, recurrence was detected in both groups (4/38 vs. 1/28; p = 0.385). Overall survival and 5-year disease-free survival did not differ between the groups (93.3 vs. 92.9%; p = 0.282 and 88.0 vs. 100.0%; p = 0.066). Conclusions: Once complete resection is achieved in patients with AEG who met the expanded criteria for endoscopic submucosal dissection of gastric cancer, there was no significant difference in clinical outcomes between ER and surgery.

UR - http://www.scopus.com/inward/record.url?scp=85041498007&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041498007&partnerID=8YFLogxK

U2 - 10.1007/s00464-018-6076-5

DO - 10.1007/s00464-018-6076-5

M3 - Article

C2 - 29417228

AN - SCOPUS:85041498007

VL - 32

SP - 3540

EP - 3547

JO - Surgical Endoscopy

JF - Surgical Endoscopy

SN - 0930-2794

IS - 8

ER -