Comparison of Low-Fat Meal and High-Fat Meal on Postprandial Lipemic Response in Non-Obese Men according to the −1131T>C Polymorphism of the Apolipoprotein A5 (APOA5) Gene (Randomized Cross-Over Design)

Ji Young Kim, Oh Yoen Kim, Soo Jeong Koh, Yangsoo Jang, Jong Ho Lee, Yangsoo Jang, Jong Ho Lee, Sung Seob Yun, Jose M. Ordovas

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: The purpose of this study was to compare low-fat (LF) meal and high-fat (HF) meal on the postprandial lipemic responses according to the −1131T>C polymorphism of the APOA5 gene in a population usually consuming a LF diet and having a high frequency of the variant allele at the APOA5 −1131T>C SNP. Methods: This study was conducted using a cross-over design and 49 non-obese healthy men (42.8 ± 0.7 yrs, 23.9 ± 0.25 kg/m2) participated in the meal tolerance test. They were randomly assigned to consume one of two types of experimental enteral formulae (LF vs HF) with a seven-day interval. Blood samples were collected at 0, 2, 3, 4 and 6h after ingestion and analyzed for total and chylomicron TG, glucose, insulin and free fatty acid. Results: No differences were found in anthropometic parameter, calorie and macronutrient intakes and total energy expenditure between TT (n = 23) and TC + CC (n = 26) men. Fasting total TG were higher in TC + CC men than TT men, but fasting chylomicron TG were not significantly different between TT men and C carriers, TT subjects had no significant differences in postprandial responses of total TG and chylomicron TG and postprandial mean changes of chylomicron TG between LF and HF meal. On the other hand, C carriers had delayed peak time of total TG compared to TT subject and higher postprandial response and mean changes of chylomicron TG at HF meal compared to LF meal. Conclusion: The capacity to clear chylomicron-TG or hydrolyze TG might become a rate-limiting factor on HF diet in TC + CC men resulting in higher postprandial triglyceridemia. Therefore, HF diet for C carriers of the APOA5 gene may be one of important CVD risk factors.

Original languageEnglish
Pages (from-to)340-347
Number of pages8
JournalJournal of the American College of Nutrition
Volume25
Issue number4
DOIs
Publication statusPublished - 2006 Aug 1

Fingerprint

Apolipoproteins C
Chylomicrons
Cross-Over Studies
Meals
Fats
Genes
High Fat Diet
Fasting
Fat-Restricted Diet
Nonesterified Fatty Acids
Gene Frequency
Energy Metabolism
Small Intestine
Single Nucleotide Polymorphism
Eating
Insulin
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

@article{90b74612b87249ffad638842fd86e552,
title = "Comparison of Low-Fat Meal and High-Fat Meal on Postprandial Lipemic Response in Non-Obese Men according to the −1131T>C Polymorphism of the Apolipoprotein A5 (APOA5) Gene (Randomized Cross-Over Design)",
abstract = "Objective: The purpose of this study was to compare low-fat (LF) meal and high-fat (HF) meal on the postprandial lipemic responses according to the −1131T>C polymorphism of the APOA5 gene in a population usually consuming a LF diet and having a high frequency of the variant allele at the APOA5 −1131T>C SNP. Methods: This study was conducted using a cross-over design and 49 non-obese healthy men (42.8 ± 0.7 yrs, 23.9 ± 0.25 kg/m2) participated in the meal tolerance test. They were randomly assigned to consume one of two types of experimental enteral formulae (LF vs HF) with a seven-day interval. Blood samples were collected at 0, 2, 3, 4 and 6h after ingestion and analyzed for total and chylomicron TG, glucose, insulin and free fatty acid. Results: No differences were found in anthropometic parameter, calorie and macronutrient intakes and total energy expenditure between TT (n = 23) and TC + CC (n = 26) men. Fasting total TG were higher in TC + CC men than TT men, but fasting chylomicron TG were not significantly different between TT men and C carriers, TT subjects had no significant differences in postprandial responses of total TG and chylomicron TG and postprandial mean changes of chylomicron TG between LF and HF meal. On the other hand, C carriers had delayed peak time of total TG compared to TT subject and higher postprandial response and mean changes of chylomicron TG at HF meal compared to LF meal. Conclusion: The capacity to clear chylomicron-TG or hydrolyze TG might become a rate-limiting factor on HF diet in TC + CC men resulting in higher postprandial triglyceridemia. Therefore, HF diet for C carriers of the APOA5 gene may be one of important CVD risk factors.",
author = "Kim, {Ji Young} and Kim, {Oh Yoen} and Koh, {Soo Jeong} and Yangsoo Jang and Lee, {Jong Ho} and Yangsoo Jang and Lee, {Jong Ho} and Yun, {Sung Seob} and Ordovas, {Jose M.}",
year = "2006",
month = "8",
day = "1",
doi = "10.1080/07315724.2006.10719544",
language = "English",
volume = "25",
pages = "340--347",
journal = "Journal of the American College of Nutrition",
issn = "0731-5724",
publisher = "American College Of Nutrition",
number = "4",

}

Comparison of Low-Fat Meal and High-Fat Meal on Postprandial Lipemic Response in Non-Obese Men according to the −1131T>C Polymorphism of the Apolipoprotein A5 (APOA5) Gene (Randomized Cross-Over Design). / Kim, Ji Young; Kim, Oh Yoen; Koh, Soo Jeong; Jang, Yangsoo; Lee, Jong Ho; Jang, Yangsoo; Lee, Jong Ho; Yun, Sung Seob; Ordovas, Jose M.

In: Journal of the American College of Nutrition, Vol. 25, No. 4, 01.08.2006, p. 340-347.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of Low-Fat Meal and High-Fat Meal on Postprandial Lipemic Response in Non-Obese Men according to the −1131T>C Polymorphism of the Apolipoprotein A5 (APOA5) Gene (Randomized Cross-Over Design)

AU - Kim, Ji Young

AU - Kim, Oh Yoen

AU - Koh, Soo Jeong

AU - Jang, Yangsoo

AU - Lee, Jong Ho

AU - Jang, Yangsoo

AU - Lee, Jong Ho

AU - Yun, Sung Seob

AU - Ordovas, Jose M.

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Objective: The purpose of this study was to compare low-fat (LF) meal and high-fat (HF) meal on the postprandial lipemic responses according to the −1131T>C polymorphism of the APOA5 gene in a population usually consuming a LF diet and having a high frequency of the variant allele at the APOA5 −1131T>C SNP. Methods: This study was conducted using a cross-over design and 49 non-obese healthy men (42.8 ± 0.7 yrs, 23.9 ± 0.25 kg/m2) participated in the meal tolerance test. They were randomly assigned to consume one of two types of experimental enteral formulae (LF vs HF) with a seven-day interval. Blood samples were collected at 0, 2, 3, 4 and 6h after ingestion and analyzed for total and chylomicron TG, glucose, insulin and free fatty acid. Results: No differences were found in anthropometic parameter, calorie and macronutrient intakes and total energy expenditure between TT (n = 23) and TC + CC (n = 26) men. Fasting total TG were higher in TC + CC men than TT men, but fasting chylomicron TG were not significantly different between TT men and C carriers, TT subjects had no significant differences in postprandial responses of total TG and chylomicron TG and postprandial mean changes of chylomicron TG between LF and HF meal. On the other hand, C carriers had delayed peak time of total TG compared to TT subject and higher postprandial response and mean changes of chylomicron TG at HF meal compared to LF meal. Conclusion: The capacity to clear chylomicron-TG or hydrolyze TG might become a rate-limiting factor on HF diet in TC + CC men resulting in higher postprandial triglyceridemia. Therefore, HF diet for C carriers of the APOA5 gene may be one of important CVD risk factors.

AB - Objective: The purpose of this study was to compare low-fat (LF) meal and high-fat (HF) meal on the postprandial lipemic responses according to the −1131T>C polymorphism of the APOA5 gene in a population usually consuming a LF diet and having a high frequency of the variant allele at the APOA5 −1131T>C SNP. Methods: This study was conducted using a cross-over design and 49 non-obese healthy men (42.8 ± 0.7 yrs, 23.9 ± 0.25 kg/m2) participated in the meal tolerance test. They were randomly assigned to consume one of two types of experimental enteral formulae (LF vs HF) with a seven-day interval. Blood samples were collected at 0, 2, 3, 4 and 6h after ingestion and analyzed for total and chylomicron TG, glucose, insulin and free fatty acid. Results: No differences were found in anthropometic parameter, calorie and macronutrient intakes and total energy expenditure between TT (n = 23) and TC + CC (n = 26) men. Fasting total TG were higher in TC + CC men than TT men, but fasting chylomicron TG were not significantly different between TT men and C carriers, TT subjects had no significant differences in postprandial responses of total TG and chylomicron TG and postprandial mean changes of chylomicron TG between LF and HF meal. On the other hand, C carriers had delayed peak time of total TG compared to TT subject and higher postprandial response and mean changes of chylomicron TG at HF meal compared to LF meal. Conclusion: The capacity to clear chylomicron-TG or hydrolyze TG might become a rate-limiting factor on HF diet in TC + CC men resulting in higher postprandial triglyceridemia. Therefore, HF diet for C carriers of the APOA5 gene may be one of important CVD risk factors.

UR - http://www.scopus.com/inward/record.url?scp=33748769502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748769502&partnerID=8YFLogxK

U2 - 10.1080/07315724.2006.10719544

DO - 10.1080/07315724.2006.10719544

M3 - Article

C2 - 16943456

AN - SCOPUS:33748769502

VL - 25

SP - 340

EP - 347

JO - Journal of the American College of Nutrition

JF - Journal of the American College of Nutrition

SN - 0731-5724

IS - 4

ER -