Comparison of methicillin-resistant staphylococcus aureus community-acquired and healthcare-associated pneumonia

Ah Young Leem, Won Jai Jung, Young Ae Kang, Seon Cheol Park, Young Jae Kim, Eu Dong Hwang, Eun Young Kim, Kyung Soo Jung, Moo Suk Park, Song Yee Kim, Young Sam Kim, Se Kyu Kim, Joon Chang, Ji Ye Jung

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4 Citations (Scopus)

Abstract

Purpose: Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as an important cause of not only healthcare-associated pneumonia (HCAP) but also community-acquired pneumonia (CAP). We determined the impact of MRSA on differences in clinical characteristics, courses, and outcomes between CAP and HCAP. Materials and Methods: We conducted a retrospective observational study on 78 adult patients admitted with MRSA pneumonia at a university-affiliated tertiary hospital between January 2008 and December 2011. We compared baseline characteristics, chest radiographs, treatment outcomes, and drug resistance patterns between the CAP and HCAP groups. Results: Of the 78 patients with MRSA pneumonia, 57 (73.1%) were HCAP and 21 (26.9%) were CAP. MRSA infection history in the previous year (29.8% vs. 14.3%, p=0.244) tended to be more common in HCAP than in CAP. Despite similar Pneumonia Severity Index scores (151 in CAP vs. 142 in HCAP), intubation rates (38.1% vs. 17.5%; p=0.072) and intensive care unit admission (42.9% vs. 22.8%; p=0.095) tended to be higher in the CAP group, while 28-day mortality was higher in the HCAP group (14.3% vs. 26.3%; p=0.368), although without statistical significance. All patients showed sensitivity to vancomycin and linezolid; meanwhile, HCAP patients showed greater resistance to gentamicin than CAP patients (58.3% vs. 16.6%; p=0.037). The median total hospital charges were 6899 American dollars for CAP and 5715 American dollars for HCAP (p=0.161). Conclusion: MRSA pneumonia showed significantly differences in baseline characteristics, chest radiographs, treatment outcomes, and medical expenses between HCAP and CAP groups.

Original languageEnglish
Pages (from-to)967-974
Number of pages8
JournalYonsei medical journal
Volume55
Issue number4
DOIs
Publication statusPublished - 2014 Jul

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Leem, A. Y., Jung, W. J., Kang, Y. A., Park, S. C., Kim, Y. J., Hwang, E. D., Kim, E. Y., Jung, K. S., Park, M. S., Kim, S. Y., Kim, Y. S., Kim, S. K., Chang, J., & Jung, J. Y. (2014). Comparison of methicillin-resistant staphylococcus aureus community-acquired and healthcare-associated pneumonia. Yonsei medical journal, 55(4), 967-974. https://doi.org/10.3349/ymj.2014.55.4.967