Comparison of Mohs micrographic surgery and wide excision for extramammary Paget's disease

Korean experience

Kyu Yeop Lee, MiRyung Roh, Woo Gil Chung, Kee Yang Chung

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

BACKGROUND: Extramammary Paget's disease (EMPD) is an uncommon tumor that usually occurs on the genitalia. It almost always extends beyond clinically apparent margins and has a high rate of recurrence. OBJECTIVE: To establish treatment guidelines for EMPD in Asian patients. METHODS: A retrospective review was done on pertinent demographic data, tumor data, treatment characteristics, and follow-up data of 35 patients between 1996 and 2006. Review of literature for treatment modalities and recurrence rates of EMPD was also performed. RESULTS: Thirty-four of the 35 patients (30 men and 5 women) had lesions in the genital area and one patient in the axilla. Mean follow-up duration was 62.7 months (8-156 months) and two of 11 (18.2%) recurred after Mohs micrographic surgery (MMS), compared with eight recurrences of 22 (36.4%) after standard wide excision. Two patients treated with nonsurgical modalities did not achieve complete remission. Estimated 5-year tumor-free rate using Kaplan-Meier graph was 69.7% in all patients, with a rate of 81.8% for MMS and 63.6% for wide excision. CONCLUSIONS: MMS is more effective, with lower recurrence rate than wide excision, and should be regarded as the first-line treatment for nonmetastatic EMPD.

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalDermatologic Surgery
Volume35
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

Fingerprint

Extramammary Paget's Disease
Mohs Surgery
Recurrence
Neoplasms
Axilla
Genitalia
Therapeutics
Demography
Guidelines

All Science Journal Classification (ASJC) codes

  • Surgery
  • Dermatology

Cite this

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title = "Comparison of Mohs micrographic surgery and wide excision for extramammary Paget's disease: Korean experience",
abstract = "BACKGROUND: Extramammary Paget's disease (EMPD) is an uncommon tumor that usually occurs on the genitalia. It almost always extends beyond clinically apparent margins and has a high rate of recurrence. OBJECTIVE: To establish treatment guidelines for EMPD in Asian patients. METHODS: A retrospective review was done on pertinent demographic data, tumor data, treatment characteristics, and follow-up data of 35 patients between 1996 and 2006. Review of literature for treatment modalities and recurrence rates of EMPD was also performed. RESULTS: Thirty-four of the 35 patients (30 men and 5 women) had lesions in the genital area and one patient in the axilla. Mean follow-up duration was 62.7 months (8-156 months) and two of 11 (18.2{\%}) recurred after Mohs micrographic surgery (MMS), compared with eight recurrences of 22 (36.4{\%}) after standard wide excision. Two patients treated with nonsurgical modalities did not achieve complete remission. Estimated 5-year tumor-free rate using Kaplan-Meier graph was 69.7{\%} in all patients, with a rate of 81.8{\%} for MMS and 63.6{\%} for wide excision. CONCLUSIONS: MMS is more effective, with lower recurrence rate than wide excision, and should be regarded as the first-line treatment for nonmetastatic EMPD.",
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Comparison of Mohs micrographic surgery and wide excision for extramammary Paget's disease : Korean experience. / Lee, Kyu Yeop; Roh, MiRyung; Chung, Woo Gil; Chung, Kee Yang.

In: Dermatologic Surgery, Vol. 35, No. 1, 01.01.2009, p. 34-40.

Research output: Contribution to journalArticle

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N2 - BACKGROUND: Extramammary Paget's disease (EMPD) is an uncommon tumor that usually occurs on the genitalia. It almost always extends beyond clinically apparent margins and has a high rate of recurrence. OBJECTIVE: To establish treatment guidelines for EMPD in Asian patients. METHODS: A retrospective review was done on pertinent demographic data, tumor data, treatment characteristics, and follow-up data of 35 patients between 1996 and 2006. Review of literature for treatment modalities and recurrence rates of EMPD was also performed. RESULTS: Thirty-four of the 35 patients (30 men and 5 women) had lesions in the genital area and one patient in the axilla. Mean follow-up duration was 62.7 months (8-156 months) and two of 11 (18.2%) recurred after Mohs micrographic surgery (MMS), compared with eight recurrences of 22 (36.4%) after standard wide excision. Two patients treated with nonsurgical modalities did not achieve complete remission. Estimated 5-year tumor-free rate using Kaplan-Meier graph was 69.7% in all patients, with a rate of 81.8% for MMS and 63.6% for wide excision. CONCLUSIONS: MMS is more effective, with lower recurrence rate than wide excision, and should be regarded as the first-line treatment for nonmetastatic EMPD.

AB - BACKGROUND: Extramammary Paget's disease (EMPD) is an uncommon tumor that usually occurs on the genitalia. It almost always extends beyond clinically apparent margins and has a high rate of recurrence. OBJECTIVE: To establish treatment guidelines for EMPD in Asian patients. METHODS: A retrospective review was done on pertinent demographic data, tumor data, treatment characteristics, and follow-up data of 35 patients between 1996 and 2006. Review of literature for treatment modalities and recurrence rates of EMPD was also performed. RESULTS: Thirty-four of the 35 patients (30 men and 5 women) had lesions in the genital area and one patient in the axilla. Mean follow-up duration was 62.7 months (8-156 months) and two of 11 (18.2%) recurred after Mohs micrographic surgery (MMS), compared with eight recurrences of 22 (36.4%) after standard wide excision. Two patients treated with nonsurgical modalities did not achieve complete remission. Estimated 5-year tumor-free rate using Kaplan-Meier graph was 69.7% in all patients, with a rate of 81.8% for MMS and 63.6% for wide excision. CONCLUSIONS: MMS is more effective, with lower recurrence rate than wide excision, and should be regarded as the first-line treatment for nonmetastatic EMPD.

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