Comparison of Monthly Ibandronate Versus Weekly Risedronate in Preference, Convenience, and Bone Turnover Markers in Korean Postmenopausal Osteoporotic Women

Yoon Sok Chung, Sung Kil Lim, Ho Yeon Chung, In Kyu Lee, Il Hyung Park, Ghi Su Kim, Yong Ki Min, Moo Il Kang, Dong Jin Chung, Yong Ki Kim, Woong Hwan Choi, Min Ho Shong, Ji Hyun Park, Dong Won Byun, Hyun Koo Yoon, Chan Soo Shin, Yil Seob Lee, Nam Hee Kwon

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Abstract

Patient preferences, convenience, and bone turnover markers were evaluated for the monthly ibandronate over the weekly risedronate regimen in Korean postmenopausal osteoporotic women. This was a 6-month, prospective, randomized, open-label, multicenter study with a two-period and two-sequence crossover treatment design. After a 30-day screening period, eligible participants with postmenopausal osteoporosis were randomized to receive either monthly oral ibandronate 150 mg for 3 months followed by weekly oral risedronate 35 mg for 12 weeks (sequence A) or the same regimen in reverse order (sequence B). Patient preference and convenience were evaluated by questionnaire. The changes in serum C-telopeptide after 3 months of treatment were analyzed. A total of 365 patients were enrolled in this study (sequence A 182, sequence B 183). Of patients expressing a preference (83.4%), 74.8% preferred the monthly ibandronate regimen over the weekly regimen (25.2%). More women stated that the monthly ibandronate regimen was more convenient (84.2%) than the weekly regimen (15.8%). There was no significant difference in the change in bone turnover marker between the two treatments. The two regimens were similarly tolerable. There were fewer adverse events in the monthly ibandronate group compared to the weekly risedronate group in terms of gastrointestinal side effects (nausea and abdominal distension). This study revealed a strong preference and convenience for monthly ibandronate over weekly risedronate in Korean postmenopausal osteoporotic women. There was no significant difference in change of bone turnover marker and safety profile between the two regimens.

Original languageEnglish
Pages (from-to)389-397
Number of pages9
JournalCalcified Tissue International
Volume85
Issue number5
DOIs
Publication statusPublished - 2009 Nov 1

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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    Chung, Y. S., Lim, S. K., Chung, H. Y., Lee, I. K., Park, I. H., Kim, G. S., Min, Y. K., Kang, M. I., Chung, D. J., Kim, Y. K., Choi, W. H., Shong, M. H., Park, J. H., Byun, D. W., Yoon, H. K., Shin, C. S., Lee, Y. S., & Kwon, N. H. (2009). Comparison of Monthly Ibandronate Versus Weekly Risedronate in Preference, Convenience, and Bone Turnover Markers in Korean Postmenopausal Osteoporotic Women. Calcified Tissue International, 85(5), 389-397. https://doi.org/10.1007/s00223-009-9294-y