ComparisOn of neointimal coVerage between zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT)

Jung Sun Kim, Byeong Kuk Kim, Ik Kyung Jang, Dong Ho Shin, Young Guk Ko, Donghoon Choi, Myeong Ki Hong, Yun Kyeong Cho, Chang Wook Nam, Seung Ho Hur, Jin Ho Choi, Young Bin Song, Joo Yong Hahn, Seung Hyuk Choi, Hyeon Cheol Gwon, Yangsoo Jang

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Background: Data on strut surface coverage of second-generation drug-eluting stents (DES) are limited. We investigated stent strut coverage of resolute zotarolimus-eluting stent (ZES-R) or everolimus-eluting stent (EES) at 9 months after implantation using optical coherence tomography (OCT). Methods: ComparisOn of neointimal coVerage betwEen zotaRolimus-eluting stent and everolimus-eluting stent using Optical Coherence Tomography (COVER OCT) is a prospective, randomized, multicenter trial comparing ZES-R to EES using OCT at 9 months after stent implantation. The primary end point was the rate of stent strut coverage at 9 months. Results: A total of 51 patients were randomized to receive either ZES-R (ZES-R group) or EES (EES group), and 47 stents (24 ZES-R and 23 EES) in 44 of 51 patients were evaluated by OCT both immediately after stent implantation and at 9 months. The neointimal thickness was not significantly different between the 2 groups at 9 months (ZES-R vs EES: 139 ± 58 vs 124 ± 42 μm, P =.31). The mean percentages of uncovered stent struts were 3.3% for ZES-R versus 3.4% for EES at 9 months (P =.51). The proportions of malapposed struts immediately after stent implantation (P =.89) and at 9-month follow-up (P =.34) were 0.8% and 0.7% for ZES-R versus 1.0% and 0.1% for EES, respectively. Thrombi were documented in 1 stent (1 [4.2%] in ZES-R vs 0 [0%] in EES). Conclusion: According to the sequential OCT evaluation, ZES-R and EES showed comparable neointimal thickness and the rate of uncovered stent strut at 9 months after stent implantation.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalAmerican heart journal
Volume163
Issue number4
DOIs
Publication statusPublished - 2012 Apr

Bibliographical note

Funding Information:
This work was supported by unrestricted grants from Medtronic, Inc, Korea , and partly supported by grants from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (No. A085012 and A000385 ); a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (No. A085136 ); and by the Cardiovascular Research Center, Seoul, Korea . The authors are solely responsible for the design, conduct, and analyses of this study and the drafting and editing of the paper.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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