Comparison of neointimal hyperplasia and peri-stent vascular remodeling after implantation of everolimus-eluting versus sirolimus-eluting stents: Intravascular ultrasound results from the EXCELLENT study

Young Guk Ko, Dong Ho Shin, Jung Sun Kim, Byeong Keuk Kim, Donghoon Choi, Myeong Ki Hong, Hyeon Cheol Gwon, Taehoon Ahn, In Ho Chae, Jung Han Yoon, Hyo Soo Kim, Yangsoo Jang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study was designed to compare neointimal hyperplasia and peri-stent arterial remodeling after implantation of everolimus-eluting stent (EES) versus sirolimuseluting stent (SES) using intravascular ultrasound (IVUS). The study population was a subgroup of 278 patients from the EXCELLENT trial, a randomized study comparing EES to SES in de novo coronary artery lesions (total n = 1,443, 3:1 randomization) who underwent post-PCI and 9-month follow-up IVUS evaluation. There were 209 patients in the EES group and 69 in the SES group. Baseline clinical and angiographic characteristics were similar between the two groups except for age and target lesion locations.At 9 months, percent neointimal volume obstruction did not differ between EES and SES (2.6 ± 4.0 % vs. 2.5 ± 4.8 %, p = 0.814). However, the relative change in the vessel (4.3 ± 13.7 % vs. 8.8 ± 18.6 %, p = 0.030) and plaque volume index (4.2 ± 17.4 % vs. 10.5 ± 22.3 %, p = 0.016) of the stented segment frompost-intervention to follow-upwas significantly less with EES than with SES. In addition, positive peri-stent vascular remodeling defined as an increase in vessel volume index[10 % (27.8 vs. 42.0 %, p = 0.027) and late acquired stent malapposition (LASM, 1.9 vs. 15.9 %, p<0.001) were observed less frequently with EES than SES. EES and SES were similarly effective in reducing neointimal hyperplasia. However, positive peri-stent vascular remodeling and LASM occurred less frequently with EES than SES.

Original languageEnglish
Pages (from-to)1229-1236
Number of pages8
JournalInternational Journal of Cardiovascular Imaging
Volume29
Issue number6
DOIs
Publication statusPublished - 2013 Aug 1

Fingerprint

Sirolimus
Hyperplasia
Stents
Everolimus
Vascular Remodeling

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

@article{292ab48de51f49da8128c4c1e6dd12e6,
title = "Comparison of neointimal hyperplasia and peri-stent vascular remodeling after implantation of everolimus-eluting versus sirolimus-eluting stents: Intravascular ultrasound results from the EXCELLENT study",
abstract = "This study was designed to compare neointimal hyperplasia and peri-stent arterial remodeling after implantation of everolimus-eluting stent (EES) versus sirolimuseluting stent (SES) using intravascular ultrasound (IVUS). The study population was a subgroup of 278 patients from the EXCELLENT trial, a randomized study comparing EES to SES in de novo coronary artery lesions (total n = 1,443, 3:1 randomization) who underwent post-PCI and 9-month follow-up IVUS evaluation. There were 209 patients in the EES group and 69 in the SES group. Baseline clinical and angiographic characteristics were similar between the two groups except for age and target lesion locations.At 9 months, percent neointimal volume obstruction did not differ between EES and SES (2.6 ± 4.0 {\%} vs. 2.5 ± 4.8 {\%}, p = 0.814). However, the relative change in the vessel (4.3 ± 13.7 {\%} vs. 8.8 ± 18.6 {\%}, p = 0.030) and plaque volume index (4.2 ± 17.4 {\%} vs. 10.5 ± 22.3 {\%}, p = 0.016) of the stented segment frompost-intervention to follow-upwas significantly less with EES than with SES. In addition, positive peri-stent vascular remodeling defined as an increase in vessel volume index[10 {\%} (27.8 vs. 42.0 {\%}, p = 0.027) and late acquired stent malapposition (LASM, 1.9 vs. 15.9 {\%}, p<0.001) were observed less frequently with EES than SES. EES and SES were similarly effective in reducing neointimal hyperplasia. However, positive peri-stent vascular remodeling and LASM occurred less frequently with EES than SES.",
author = "Ko, {Young Guk} and Shin, {Dong Ho} and Kim, {Jung Sun} and Kim, {Byeong Keuk} and Donghoon Choi and Hong, {Myeong Ki} and Gwon, {Hyeon Cheol} and Taehoon Ahn and Chae, {In Ho} and Yoon, {Jung Han} and Kim, {Hyo Soo} and Yangsoo Jang",
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Comparison of neointimal hyperplasia and peri-stent vascular remodeling after implantation of everolimus-eluting versus sirolimus-eluting stents : Intravascular ultrasound results from the EXCELLENT study. / Ko, Young Guk; Shin, Dong Ho; Kim, Jung Sun; Kim, Byeong Keuk; Choi, Donghoon; Hong, Myeong Ki; Gwon, Hyeon Cheol; Ahn, Taehoon; Chae, In Ho; Yoon, Jung Han; Kim, Hyo Soo; Jang, Yangsoo.

In: International Journal of Cardiovascular Imaging, Vol. 29, No. 6, 01.08.2013, p. 1229-1236.

Research output: Contribution to journalArticle

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T1 - Comparison of neointimal hyperplasia and peri-stent vascular remodeling after implantation of everolimus-eluting versus sirolimus-eluting stents

T2 - Intravascular ultrasound results from the EXCELLENT study

AU - Ko, Young Guk

AU - Shin, Dong Ho

AU - Kim, Jung Sun

AU - Kim, Byeong Keuk

AU - Choi, Donghoon

AU - Hong, Myeong Ki

AU - Gwon, Hyeon Cheol

AU - Ahn, Taehoon

AU - Chae, In Ho

AU - Yoon, Jung Han

AU - Kim, Hyo Soo

AU - Jang, Yangsoo

PY - 2013/8/1

Y1 - 2013/8/1

N2 - This study was designed to compare neointimal hyperplasia and peri-stent arterial remodeling after implantation of everolimus-eluting stent (EES) versus sirolimuseluting stent (SES) using intravascular ultrasound (IVUS). The study population was a subgroup of 278 patients from the EXCELLENT trial, a randomized study comparing EES to SES in de novo coronary artery lesions (total n = 1,443, 3:1 randomization) who underwent post-PCI and 9-month follow-up IVUS evaluation. There were 209 patients in the EES group and 69 in the SES group. Baseline clinical and angiographic characteristics were similar between the two groups except for age and target lesion locations.At 9 months, percent neointimal volume obstruction did not differ between EES and SES (2.6 ± 4.0 % vs. 2.5 ± 4.8 %, p = 0.814). However, the relative change in the vessel (4.3 ± 13.7 % vs. 8.8 ± 18.6 %, p = 0.030) and plaque volume index (4.2 ± 17.4 % vs. 10.5 ± 22.3 %, p = 0.016) of the stented segment frompost-intervention to follow-upwas significantly less with EES than with SES. In addition, positive peri-stent vascular remodeling defined as an increase in vessel volume index[10 % (27.8 vs. 42.0 %, p = 0.027) and late acquired stent malapposition (LASM, 1.9 vs. 15.9 %, p<0.001) were observed less frequently with EES than SES. EES and SES were similarly effective in reducing neointimal hyperplasia. However, positive peri-stent vascular remodeling and LASM occurred less frequently with EES than SES.

AB - This study was designed to compare neointimal hyperplasia and peri-stent arterial remodeling after implantation of everolimus-eluting stent (EES) versus sirolimuseluting stent (SES) using intravascular ultrasound (IVUS). The study population was a subgroup of 278 patients from the EXCELLENT trial, a randomized study comparing EES to SES in de novo coronary artery lesions (total n = 1,443, 3:1 randomization) who underwent post-PCI and 9-month follow-up IVUS evaluation. There were 209 patients in the EES group and 69 in the SES group. Baseline clinical and angiographic characteristics were similar between the two groups except for age and target lesion locations.At 9 months, percent neointimal volume obstruction did not differ between EES and SES (2.6 ± 4.0 % vs. 2.5 ± 4.8 %, p = 0.814). However, the relative change in the vessel (4.3 ± 13.7 % vs. 8.8 ± 18.6 %, p = 0.030) and plaque volume index (4.2 ± 17.4 % vs. 10.5 ± 22.3 %, p = 0.016) of the stented segment frompost-intervention to follow-upwas significantly less with EES than with SES. In addition, positive peri-stent vascular remodeling defined as an increase in vessel volume index[10 % (27.8 vs. 42.0 %, p = 0.027) and late acquired stent malapposition (LASM, 1.9 vs. 15.9 %, p<0.001) were observed less frequently with EES than SES. EES and SES were similarly effective in reducing neointimal hyperplasia. However, positive peri-stent vascular remodeling and LASM occurred less frequently with EES than SES.

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