Comparison of outcomes of patients with painless versus painful ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention

Jae Yeong Cho, Myung Ho Jeong, Young Keun Ahn, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, Taek Jong Hong, Dong Hoon Choi, Myeong Chan Cho, Chong Jin Kim, Ki Bae Seung, Wook Sung Chung, Yang Soo Jang, Seung Yun Cho, Seung Woon Rha, Jang Ho Bae, Jeong Gwan Cho, Seung Jung Park

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21 Citations (Scopus)


There are few data available on the prognosis of painless ST-segment elevation myocardial infarction (STEMI). The aim of this study was to determine the incidence, clinical characteristics, and outcomes of painless STEMI. We analyzed the Korea Acute Myocardial Infarction Registry (KAMIR) study, which enrolled 7,288 patients with STEMI (61.8 ± 12.8 years old, 74% men; painless STEMI group, n = 763; painful STEMI group, n = 6,525). End points were in-hospital mortality and 1-year major adverse cardiac events (MACEs). Patients with painless STEMI were older and more likely to be women, nonsmokers, diabetic, and normolipidemic and to have a higher Killip class. The painless group had more in-hospital deaths (5.9% vs 3.6%, p = 0.026) and 1-year MACEs (26% vs 19%, p = 0.002). In Cox proportional hazards analysis, hypotension (hazard ratio [HR] 4.40, 95% confidence interval [CI] 1.41 to 13.78, p = 0.011), low left ventricular ejection fraction (HR 3.12, 95% CI 1.21 to 8.07, p = 0.019), and a high Killip class (HR 3.48, 95% CI 1.19 to 10.22, p = 0.023) were independent predictors of 1-year MACEs in patients with painless STEMI. In conclusion, painless STEMI was associated with more adverse outcomes than painful STEMI and late detection may have contributed significantly to total ischemic burden. These results warrant more investigations for methodologic development in the diagnosis of silent ischemia and painless STEMI.

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalAmerican Journal of Cardiology
Issue number3
Publication statusPublished - 2012 Feb 1

Bibliographical note

Funding Information:
This study was supported by a grant from the Korean Society of Circulation , Seoul, Republic of Korea, in celebration of its 50th Anniversary and the Korea Healthcare Technology R&D Project ( A084869 ), Ministry for Health, Welfare and Family Affairs , Seoul, Republic of Korea, and the Cardiovascular Research Foundation Asia , Seoul, Republic of Korea.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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