Comparison of radiation therapy alone and concurrent chemoradiation therapy in stage III cervical cancer

A multicenter retrospective study

Jong Min Lee, Seo Yun Tong, Kwang Beom Lee, YoungTae Kim, Young Jae Kim, Jae Weon Kim, Seok Mo Kim, Chi Heum Cho, Ki Tae Kim, Young Lae Cho, Kyu Chan Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective. To evaluate whether concurrent chemoradiation therapy (CRT) improves overall survival as compared to radiation therapy (RT) alone in stage III cervical cancers. Design. A multicenter retrospective review. Setting. Nine tertiary medical centers in Korea. Population. A total of 277 patients treated for stage III cervical cancer without para-aortic lymph node (PALN) metastasis based on clinical staging workup from 1996 to 2003. Methods. Medical and histopathological record review. Main outcome measures. Disease-specific overall survival. Results. CRT and RT alone were performed in 172 and 105 patients, respectively. There was no significant difference in disease-specific overall survival between the CRT and RT alone arms based on clinical staging workup, even though the CRT arm was characterized by younger age, more favorable performance status and lower pretreatment blood urea nitrogen level as compared to the RT alone arm. In the CRT arm, three patients succumbed to treatment-related death. Conclusion. CRT does not improve the overall survival rate in stage III cervical cancer as compared to RT alone based on clinical staging workup for PALN status. Special care needs to be taken regarding optimal dose and duration of RT, use of brachytherapy, anemia control and accurate pretreatment staging workup to improve survival outcome in patients with stage III cervical cancer.

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalActa obstetricia et gynecologica Scandinavica
Volume88
Issue number6
DOIs
Publication statusPublished - 2009 Jul 30

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Uterine Cervical Neoplasms
Multicenter Studies
Radiotherapy
Retrospective Studies
Survival
Therapeutics
Lymph Nodes
Blood Urea Nitrogen
Brachytherapy
Korea
Medical Records
Anemia
Survival Rate
Outcome Assessment (Health Care)
Neoplasm Metastasis
Population

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Lee, Jong Min ; Tong, Seo Yun ; Lee, Kwang Beom ; Kim, YoungTae ; Kim, Young Jae ; Kim, Jae Weon ; Kim, Seok Mo ; Cho, Chi Heum ; Kim, Ki Tae ; Cho, Young Lae ; Lee, Kyu Chan. / Comparison of radiation therapy alone and concurrent chemoradiation therapy in stage III cervical cancer : A multicenter retrospective study. In: Acta obstetricia et gynecologica Scandinavica. 2009 ; Vol. 88, No. 6. pp. 707-712.
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abstract = "Objective. To evaluate whether concurrent chemoradiation therapy (CRT) improves overall survival as compared to radiation therapy (RT) alone in stage III cervical cancers. Design. A multicenter retrospective review. Setting. Nine tertiary medical centers in Korea. Population. A total of 277 patients treated for stage III cervical cancer without para-aortic lymph node (PALN) metastasis based on clinical staging workup from 1996 to 2003. Methods. Medical and histopathological record review. Main outcome measures. Disease-specific overall survival. Results. CRT and RT alone were performed in 172 and 105 patients, respectively. There was no significant difference in disease-specific overall survival between the CRT and RT alone arms based on clinical staging workup, even though the CRT arm was characterized by younger age, more favorable performance status and lower pretreatment blood urea nitrogen level as compared to the RT alone arm. In the CRT arm, three patients succumbed to treatment-related death. Conclusion. CRT does not improve the overall survival rate in stage III cervical cancer as compared to RT alone based on clinical staging workup for PALN status. Special care needs to be taken regarding optimal dose and duration of RT, use of brachytherapy, anemia control and accurate pretreatment staging workup to improve survival outcome in patients with stage III cervical cancer.",
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Comparison of radiation therapy alone and concurrent chemoradiation therapy in stage III cervical cancer : A multicenter retrospective study. / Lee, Jong Min; Tong, Seo Yun; Lee, Kwang Beom; Kim, YoungTae; Kim, Young Jae; Kim, Jae Weon; Kim, Seok Mo; Cho, Chi Heum; Kim, Ki Tae; Cho, Young Lae; Lee, Kyu Chan.

In: Acta obstetricia et gynecologica Scandinavica, Vol. 88, No. 6, 30.07.2009, p. 707-712.

Research output: Contribution to journalArticle

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T1 - Comparison of radiation therapy alone and concurrent chemoradiation therapy in stage III cervical cancer

T2 - A multicenter retrospective study

AU - Lee, Jong Min

AU - Tong, Seo Yun

AU - Lee, Kwang Beom

AU - Kim, YoungTae

AU - Kim, Young Jae

AU - Kim, Jae Weon

AU - Kim, Seok Mo

AU - Cho, Chi Heum

AU - Kim, Ki Tae

AU - Cho, Young Lae

AU - Lee, Kyu Chan

PY - 2009/7/30

Y1 - 2009/7/30

N2 - Objective. To evaluate whether concurrent chemoradiation therapy (CRT) improves overall survival as compared to radiation therapy (RT) alone in stage III cervical cancers. Design. A multicenter retrospective review. Setting. Nine tertiary medical centers in Korea. Population. A total of 277 patients treated for stage III cervical cancer without para-aortic lymph node (PALN) metastasis based on clinical staging workup from 1996 to 2003. Methods. Medical and histopathological record review. Main outcome measures. Disease-specific overall survival. Results. CRT and RT alone were performed in 172 and 105 patients, respectively. There was no significant difference in disease-specific overall survival between the CRT and RT alone arms based on clinical staging workup, even though the CRT arm was characterized by younger age, more favorable performance status and lower pretreatment blood urea nitrogen level as compared to the RT alone arm. In the CRT arm, three patients succumbed to treatment-related death. Conclusion. CRT does not improve the overall survival rate in stage III cervical cancer as compared to RT alone based on clinical staging workup for PALN status. Special care needs to be taken regarding optimal dose and duration of RT, use of brachytherapy, anemia control and accurate pretreatment staging workup to improve survival outcome in patients with stage III cervical cancer.

AB - Objective. To evaluate whether concurrent chemoradiation therapy (CRT) improves overall survival as compared to radiation therapy (RT) alone in stage III cervical cancers. Design. A multicenter retrospective review. Setting. Nine tertiary medical centers in Korea. Population. A total of 277 patients treated for stage III cervical cancer without para-aortic lymph node (PALN) metastasis based on clinical staging workup from 1996 to 2003. Methods. Medical and histopathological record review. Main outcome measures. Disease-specific overall survival. Results. CRT and RT alone were performed in 172 and 105 patients, respectively. There was no significant difference in disease-specific overall survival between the CRT and RT alone arms based on clinical staging workup, even though the CRT arm was characterized by younger age, more favorable performance status and lower pretreatment blood urea nitrogen level as compared to the RT alone arm. In the CRT arm, three patients succumbed to treatment-related death. Conclusion. CRT does not improve the overall survival rate in stage III cervical cancer as compared to RT alone based on clinical staging workup for PALN status. Special care needs to be taken regarding optimal dose and duration of RT, use of brachytherapy, anemia control and accurate pretreatment staging workup to improve survival outcome in patients with stage III cervical cancer.

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