Comparison of sirolimus-eluting stent and paclitaxel-eluting stent for long-term cardiac adverse events in diabetic patients: The Korean multicenter angioplasty team (KOMATE) registry

Jung Sun Kim, Byoung Ho Lee, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Pil Ki Min, Young Won Yoon, Bum Kee Hong, Hyuck Moon Kwon, Min Soo Ahn, Seung Hwan Lee, Jung Han Yoon, Byoung Kwon Lee, Byung Ok Kim, Byeong Kuk Kim, Sung Jin Oh, Dong Woon Jeon, Joo Young Yang, Jung Rae Cho, Jae Hun JungSeung Ki Ryu, K. Kwon, S. H. Park, Y. S. Byun, C. W. Ko

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Background: There is some controversy on long-term cardiac outcomes between sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in diabetes mellitus (DM). We compared cardiac adverse events after SES and PES implantation in patients with DM over a period of 3 year. Methods: A total of 634 patients with DM treated with SES (n 5 428) or PES (n 5 206) were consecutively enrolled in the KOMATE registry from 2003 to 2004. We assessed major adverse cardiac events (MACEs, cardiovascular death, non-fatal myocardial infarction, ischemia driven target vessel revascularization) and stent thrombosis (ST) according to the definitions set by the Academic Research Consortium. Results: Propensity score (PS) analysis was performed to adjust different baseline characteristics. The mean follow-up duration was 38 ± 8 month (at least 36 month and up to 53 month). The 3-year MACE rate did not show a significant difference between the two groups [52 (12.1%) in SES vs. 29 (14.1%) in PES, P = 0.496]. The definite and probable ST at 3 year were similar in both SES and PES [12 (2.8%) in SES vs. 7 (3.4%) in PES, P = 0.681]. There were no differences in hazard ratio for MACE and ST between two stents [MACE, crude: 0.844 (0.536-1.330) and adjusted for PS: 0.858 (0.530-1.389); ST, crude: 0.820 (0.323-2.083) and adjusted for PS: 0.960 (0.357-2.587)]. Conclusions: The present study demonstrated that long-tem cardiac outcomes including ST were not significantly different between SES and PES in patients with DM.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Issue number5
Publication statusPublished - 2008 Nov 1


All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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