Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy

Yun Jin Lee, hoonchul kang, Sun Joon Bae, HeungDong Kim, Jeong Tae Kim, Byung In Lee, Kyoung Heo, JinWoo Chang, Dong Seok Kim, Tae Seung Kim, Joon Soo Lee

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Introduction: The aim of the study was to assess the difference in clinical characteristics and postsurgical outcomes between children and adults who have undergone temporal lobectomy (TL). Materials and methods: We retrospectively reviewed the medical records of 52 patients who had undergone TL between 2006 and 2008. Nineteen patients were classified as children (≤18 years old), and 33 patients were classified as adults (>18 years old) according to the age when TL had been performed. Results: Twelve of 19 (63.2%) children and 24 of 33 (72.7%) adults became seizure free. Rapid secondary generalization such as generalized tonic or tonic-clonic seizures showed a tendency to be more prominent in children (four of 19, 21.1%) than in adults (three of 33, 9.1%). Patients in childhood had significantly more multifocal discharges on interictal electroencephalography (EEG) (42.1%) compared to adults (15.2%, p=0.014). The mean extent of surgical excision was 5.0 cm in children and 4.1 cm in adults (p=0.001). The incidence of hippocampal sclerosis, the most common pathologic finding in the two groups, was 57.9% (11 of 19) in children and 78.8% (26 of 33) in adults. Malformations of cortical development were significantly more frequent in children (nine of 19, 47.4%) than in adults (seven of 33, 21.2%). Dual pathology was found in 31.6% of children and in 12.1% of adults. The intelligence quotient and memory quotient values in children with temporal lobe resection remained nearly steady during follow-up period without significant decline. Conclusion: Patients undergoing TL during childhood compared to during adulthood had distinctively different interictal EEG, resectional extents, and pathologic findings.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalChild's Nervous System
Volume26
Issue number2
DOIs
Publication statusPublished - 2010 Jan 1

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Temporal Lobe Epilepsy
Electroencephalography
Seizures
Drug Resistant Epilepsy
Malformations of Cortical Development
Sclerosis
Temporal Lobe
Intelligence
Medical Records
Pathology
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Lee, Yun Jin ; kang, hoonchul ; Bae, Sun Joon ; Kim, HeungDong ; Kim, Jeong Tae ; Lee, Byung In ; Heo, Kyoung ; Chang, JinWoo ; Kim, Dong Seok ; Kim, Tae Seung ; Lee, Joon Soo. / Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy. In: Child's Nervous System. 2010 ; Vol. 26, No. 2. pp. 177-183.
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title = "Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy",
abstract = "Introduction: The aim of the study was to assess the difference in clinical characteristics and postsurgical outcomes between children and adults who have undergone temporal lobectomy (TL). Materials and methods: We retrospectively reviewed the medical records of 52 patients who had undergone TL between 2006 and 2008. Nineteen patients were classified as children (≤18 years old), and 33 patients were classified as adults (>18 years old) according to the age when TL had been performed. Results: Twelve of 19 (63.2{\%}) children and 24 of 33 (72.7{\%}) adults became seizure free. Rapid secondary generalization such as generalized tonic or tonic-clonic seizures showed a tendency to be more prominent in children (four of 19, 21.1{\%}) than in adults (three of 33, 9.1{\%}). Patients in childhood had significantly more multifocal discharges on interictal electroencephalography (EEG) (42.1{\%}) compared to adults (15.2{\%}, p=0.014). The mean extent of surgical excision was 5.0 cm in children and 4.1 cm in adults (p=0.001). The incidence of hippocampal sclerosis, the most common pathologic finding in the two groups, was 57.9{\%} (11 of 19) in children and 78.8{\%} (26 of 33) in adults. Malformations of cortical development were significantly more frequent in children (nine of 19, 47.4{\%}) than in adults (seven of 33, 21.2{\%}). Dual pathology was found in 31.6{\%} of children and in 12.1{\%} of adults. The intelligence quotient and memory quotient values in children with temporal lobe resection remained nearly steady during follow-up period without significant decline. Conclusion: Patients undergoing TL during childhood compared to during adulthood had distinctively different interictal EEG, resectional extents, and pathologic findings.",
author = "Lee, {Yun Jin} and hoonchul kang and Bae, {Sun Joon} and HeungDong Kim and Kim, {Jeong Tae} and Lee, {Byung In} and Kyoung Heo and JinWoo Chang and Kim, {Dong Seok} and Kim, {Tae Seung} and Lee, {Joon Soo}",
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Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy. / Lee, Yun Jin; kang, hoonchul; Bae, Sun Joon; Kim, HeungDong; Kim, Jeong Tae; Lee, Byung In; Heo, Kyoung; Chang, JinWoo; Kim, Dong Seok; Kim, Tae Seung; Lee, Joon Soo.

In: Child's Nervous System, Vol. 26, No. 2, 01.01.2010, p. 177-183.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy

AU - Lee, Yun Jin

AU - kang, hoonchul

AU - Bae, Sun Joon

AU - Kim, HeungDong

AU - Kim, Jeong Tae

AU - Lee, Byung In

AU - Heo, Kyoung

AU - Chang, JinWoo

AU - Kim, Dong Seok

AU - Kim, Tae Seung

AU - Lee, Joon Soo

PY - 2010/1/1

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N2 - Introduction: The aim of the study was to assess the difference in clinical characteristics and postsurgical outcomes between children and adults who have undergone temporal lobectomy (TL). Materials and methods: We retrospectively reviewed the medical records of 52 patients who had undergone TL between 2006 and 2008. Nineteen patients were classified as children (≤18 years old), and 33 patients were classified as adults (>18 years old) according to the age when TL had been performed. Results: Twelve of 19 (63.2%) children and 24 of 33 (72.7%) adults became seizure free. Rapid secondary generalization such as generalized tonic or tonic-clonic seizures showed a tendency to be more prominent in children (four of 19, 21.1%) than in adults (three of 33, 9.1%). Patients in childhood had significantly more multifocal discharges on interictal electroencephalography (EEG) (42.1%) compared to adults (15.2%, p=0.014). The mean extent of surgical excision was 5.0 cm in children and 4.1 cm in adults (p=0.001). The incidence of hippocampal sclerosis, the most common pathologic finding in the two groups, was 57.9% (11 of 19) in children and 78.8% (26 of 33) in adults. Malformations of cortical development were significantly more frequent in children (nine of 19, 47.4%) than in adults (seven of 33, 21.2%). Dual pathology was found in 31.6% of children and in 12.1% of adults. The intelligence quotient and memory quotient values in children with temporal lobe resection remained nearly steady during follow-up period without significant decline. Conclusion: Patients undergoing TL during childhood compared to during adulthood had distinctively different interictal EEG, resectional extents, and pathologic findings.

AB - Introduction: The aim of the study was to assess the difference in clinical characteristics and postsurgical outcomes between children and adults who have undergone temporal lobectomy (TL). Materials and methods: We retrospectively reviewed the medical records of 52 patients who had undergone TL between 2006 and 2008. Nineteen patients were classified as children (≤18 years old), and 33 patients were classified as adults (>18 years old) according to the age when TL had been performed. Results: Twelve of 19 (63.2%) children and 24 of 33 (72.7%) adults became seizure free. Rapid secondary generalization such as generalized tonic or tonic-clonic seizures showed a tendency to be more prominent in children (four of 19, 21.1%) than in adults (three of 33, 9.1%). Patients in childhood had significantly more multifocal discharges on interictal electroencephalography (EEG) (42.1%) compared to adults (15.2%, p=0.014). The mean extent of surgical excision was 5.0 cm in children and 4.1 cm in adults (p=0.001). The incidence of hippocampal sclerosis, the most common pathologic finding in the two groups, was 57.9% (11 of 19) in children and 78.8% (26 of 33) in adults. Malformations of cortical development were significantly more frequent in children (nine of 19, 47.4%) than in adults (seven of 33, 21.2%). Dual pathology was found in 31.6% of children and in 12.1% of adults. The intelligence quotient and memory quotient values in children with temporal lobe resection remained nearly steady during follow-up period without significant decline. Conclusion: Patients undergoing TL during childhood compared to during adulthood had distinctively different interictal EEG, resectional extents, and pathologic findings.

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