Comparison of TGF-β1 in tears following laser subepithelial keratomileusis and photorefractive keratectomy

Jae Bum Lee, Chul Myong Choe, Hyon S. Kim, KyoungYul Seo, Gong Je Seong, Eungkweon Kim

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To compare the release of tear fluid transforming growth factor-β1 (TGF-β1) of 15 patients who underwent photorefractive keratectomy (PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the other eye. METHODS: Tear fluid samples were collected with scaled microcapillary tubes preoperatively (day 0) and on the first, second, and seventh postoperative days. We calculated the release of TGF-β1 (tear fluid flow-corrected concentrations of TGF-β1) by multiplying the concentration by capillary tear fluid flow and also evaluated corneal haze at 1, 3, and 6 months after PRK or LASEK. RESULTS: The median TGF-β1 release values were: Day 0: 50.6 pg/min (range 0 to 101.6 pg/min) for PRK and 56.7 pg/min (range 0 to 121.8 pg/min) for LASEK (P=.496); Day 1: 240.6 pg/min (range 56.6 to 1120.2 pg/min) for PRK and 155.2 pg/min (range 45.1 to 480.4 pg/min) for LASEK, which showed a significant difference between the two procedures (P=.041); Day 2: 395.7 pg/min (range 92.3 to 1150.7 pg/min) for PRK and 185.2 pg/min (range 41.4 to 872.5 pg/min) for LASEK (P=.004); and Day 7: 91.3 pg/min (range 0 to 225.4 pg/min) for PRK and 74.3 pg/min (range 0 to 187.1 pg/min) for LASEK, (P=.244). The mean corneal haze score at 1 month after PRK was 0.88 ± 0.50 and 0.53 ± 0.29 after LASEK, and a statistically significant difference was noted between the two groups (P=.005). At 3 months (P=.083) and 6 months (P=.157) after the procedures, there were no statistically significant differences. CONCLUSIONS: A lower amount of tear fluid transforming growht factor-β1 was released in the early postoperative days of following LASEK than in LASEK. The lower grade of corneal haze seen in LASEK than PRK in the early postoperative period may come from a decreased release of TGF-β1, which may have a role in wound healing.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalJournal of Refractive Surgery
Volume18
Issue number2
Publication statusPublished - 2002 Jan 1

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Laser-Assisted Subepithelial Keratectomy
Transforming Growth Factors
Tears
Photorefractive Keratectomy
Postoperative Period
Wound Healing

All Science Journal Classification (ASJC) codes

  • Surgery
  • Ophthalmology

Cite this

@article{956e68a6af4e450cb3f91f39a3a0d902,
title = "Comparison of TGF-β1 in tears following laser subepithelial keratomileusis and photorefractive keratectomy",
abstract = "PURPOSE: To compare the release of tear fluid transforming growth factor-β1 (TGF-β1) of 15 patients who underwent photorefractive keratectomy (PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the other eye. METHODS: Tear fluid samples were collected with scaled microcapillary tubes preoperatively (day 0) and on the first, second, and seventh postoperative days. We calculated the release of TGF-β1 (tear fluid flow-corrected concentrations of TGF-β1) by multiplying the concentration by capillary tear fluid flow and also evaluated corneal haze at 1, 3, and 6 months after PRK or LASEK. RESULTS: The median TGF-β1 release values were: Day 0: 50.6 pg/min (range 0 to 101.6 pg/min) for PRK and 56.7 pg/min (range 0 to 121.8 pg/min) for LASEK (P=.496); Day 1: 240.6 pg/min (range 56.6 to 1120.2 pg/min) for PRK and 155.2 pg/min (range 45.1 to 480.4 pg/min) for LASEK, which showed a significant difference between the two procedures (P=.041); Day 2: 395.7 pg/min (range 92.3 to 1150.7 pg/min) for PRK and 185.2 pg/min (range 41.4 to 872.5 pg/min) for LASEK (P=.004); and Day 7: 91.3 pg/min (range 0 to 225.4 pg/min) for PRK and 74.3 pg/min (range 0 to 187.1 pg/min) for LASEK, (P=.244). The mean corneal haze score at 1 month after PRK was 0.88 ± 0.50 and 0.53 ± 0.29 after LASEK, and a statistically significant difference was noted between the two groups (P=.005). At 3 months (P=.083) and 6 months (P=.157) after the procedures, there were no statistically significant differences. CONCLUSIONS: A lower amount of tear fluid transforming growht factor-β1 was released in the early postoperative days of following LASEK than in LASEK. The lower grade of corneal haze seen in LASEK than PRK in the early postoperative period may come from a decreased release of TGF-β1, which may have a role in wound healing.",
author = "Lee, {Jae Bum} and Choe, {Chul Myong} and Kim, {Hyon S.} and KyoungYul Seo and Seong, {Gong Je} and Eungkweon Kim",
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language = "English",
volume = "18",
pages = "130--134",
journal = "Journal of Refractive Surgery",
issn = "1081-597X",
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Comparison of TGF-β1 in tears following laser subepithelial keratomileusis and photorefractive keratectomy. / Lee, Jae Bum; Choe, Chul Myong; Kim, Hyon S.; Seo, KyoungYul; Seong, Gong Je; Kim, Eungkweon.

In: Journal of Refractive Surgery, Vol. 18, No. 2, 01.01.2002, p. 130-134.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of TGF-β1 in tears following laser subepithelial keratomileusis and photorefractive keratectomy

AU - Lee, Jae Bum

AU - Choe, Chul Myong

AU - Kim, Hyon S.

AU - Seo, KyoungYul

AU - Seong, Gong Je

AU - Kim, Eungkweon

PY - 2002/1/1

Y1 - 2002/1/1

N2 - PURPOSE: To compare the release of tear fluid transforming growth factor-β1 (TGF-β1) of 15 patients who underwent photorefractive keratectomy (PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the other eye. METHODS: Tear fluid samples were collected with scaled microcapillary tubes preoperatively (day 0) and on the first, second, and seventh postoperative days. We calculated the release of TGF-β1 (tear fluid flow-corrected concentrations of TGF-β1) by multiplying the concentration by capillary tear fluid flow and also evaluated corneal haze at 1, 3, and 6 months after PRK or LASEK. RESULTS: The median TGF-β1 release values were: Day 0: 50.6 pg/min (range 0 to 101.6 pg/min) for PRK and 56.7 pg/min (range 0 to 121.8 pg/min) for LASEK (P=.496); Day 1: 240.6 pg/min (range 56.6 to 1120.2 pg/min) for PRK and 155.2 pg/min (range 45.1 to 480.4 pg/min) for LASEK, which showed a significant difference between the two procedures (P=.041); Day 2: 395.7 pg/min (range 92.3 to 1150.7 pg/min) for PRK and 185.2 pg/min (range 41.4 to 872.5 pg/min) for LASEK (P=.004); and Day 7: 91.3 pg/min (range 0 to 225.4 pg/min) for PRK and 74.3 pg/min (range 0 to 187.1 pg/min) for LASEK, (P=.244). The mean corneal haze score at 1 month after PRK was 0.88 ± 0.50 and 0.53 ± 0.29 after LASEK, and a statistically significant difference was noted between the two groups (P=.005). At 3 months (P=.083) and 6 months (P=.157) after the procedures, there were no statistically significant differences. CONCLUSIONS: A lower amount of tear fluid transforming growht factor-β1 was released in the early postoperative days of following LASEK than in LASEK. The lower grade of corneal haze seen in LASEK than PRK in the early postoperative period may come from a decreased release of TGF-β1, which may have a role in wound healing.

AB - PURPOSE: To compare the release of tear fluid transforming growth factor-β1 (TGF-β1) of 15 patients who underwent photorefractive keratectomy (PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the other eye. METHODS: Tear fluid samples were collected with scaled microcapillary tubes preoperatively (day 0) and on the first, second, and seventh postoperative days. We calculated the release of TGF-β1 (tear fluid flow-corrected concentrations of TGF-β1) by multiplying the concentration by capillary tear fluid flow and also evaluated corneal haze at 1, 3, and 6 months after PRK or LASEK. RESULTS: The median TGF-β1 release values were: Day 0: 50.6 pg/min (range 0 to 101.6 pg/min) for PRK and 56.7 pg/min (range 0 to 121.8 pg/min) for LASEK (P=.496); Day 1: 240.6 pg/min (range 56.6 to 1120.2 pg/min) for PRK and 155.2 pg/min (range 45.1 to 480.4 pg/min) for LASEK, which showed a significant difference between the two procedures (P=.041); Day 2: 395.7 pg/min (range 92.3 to 1150.7 pg/min) for PRK and 185.2 pg/min (range 41.4 to 872.5 pg/min) for LASEK (P=.004); and Day 7: 91.3 pg/min (range 0 to 225.4 pg/min) for PRK and 74.3 pg/min (range 0 to 187.1 pg/min) for LASEK, (P=.244). The mean corneal haze score at 1 month after PRK was 0.88 ± 0.50 and 0.53 ± 0.29 after LASEK, and a statistically significant difference was noted between the two groups (P=.005). At 3 months (P=.083) and 6 months (P=.157) after the procedures, there were no statistically significant differences. CONCLUSIONS: A lower amount of tear fluid transforming growht factor-β1 was released in the early postoperative days of following LASEK than in LASEK. The lower grade of corneal haze seen in LASEK than PRK in the early postoperative period may come from a decreased release of TGF-β1, which may have a role in wound healing.

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