Comparison of the clinical characteristics of renal transplant recipients who underwent early versus late graft nephrectomy

I. O. Sun, Y. A. Hong, H. S. Park, S. R. Choi, B. H. Chung, J. I. Kim, B. S. Choi, C. W. Park, YuSeun Kim, I. S. Moon, C. W. Yang

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4 Citations (Scopus)

Abstract

AbstractBackground Graft nephrectomy is the last-resort option for renal transplant recipients. The aim of this study was to compare the clinical characteristics of patients who underwent graft nephrectomy according to the time after renal transplantation. Methods From 2005 to 2012, 42 patients underwent graft nephrectomy after transplant failure. We divided these patients into early (n = 17) and late graft nephrectomy (n = 25) groups based on graft survival to 6 months, comparing their causes for nephrectomy and clinical characteristics. Results The patients included 29 men and 13 women, with an overall mean age of 45 years (range, 10-71 years). The main causes for early and late graft nephrectomy were irreversible acute rejection (71%) and graft intolerance syndrome (95%), respectively. The clinical characteristics did not significantly differ between the early and late graft nephrectomy groups except for operative-related complications. Bleeding was more common among patients who underwent early (n = 10) versus late (n = 3) graft nephrectomy (59% vs 12%; P =.01). Of the 10 patients with perioperative bleeding, 8 had a bleeding tendency, such as low platelet count or prolonged prothrombin time at the time of the operation. These complications occurred after antirejection therapy involving plasma exchange or antithymocyte globulin treatment. Allograft nephrectomy was associated with a mortality rate of 2.38%. Conclusions The cause for graft nephrectomy and type of perioperative complication differed according to timing of graft nephrectomy. Antirejection therapy appeared to contribute to postoperative complications such as bleeding.

Original languageEnglish
Pages (from-to)2953-2956
Number of pages4
JournalTransplantation Proceedings
Volume45
Issue number8
DOIs
Publication statusPublished - 2013 Oct 1

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Nephrectomy
Transplants
Kidney
Hemorrhage
Immunosuppression
Transplant Recipients
Plasma Exchange
Antilymphocyte Serum
Prothrombin Time
Graft Rejection
Graft Survival
Platelet Count
Kidney Transplantation
Allografts
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Sun, I. O. ; Hong, Y. A. ; Park, H. S. ; Choi, S. R. ; Chung, B. H. ; Kim, J. I. ; Choi, B. S. ; Park, C. W. ; Kim, YuSeun ; Moon, I. S. ; Yang, C. W. / Comparison of the clinical characteristics of renal transplant recipients who underwent early versus late graft nephrectomy. In: Transplantation Proceedings. 2013 ; Vol. 45, No. 8. pp. 2953-2956.
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abstract = "AbstractBackground Graft nephrectomy is the last-resort option for renal transplant recipients. The aim of this study was to compare the clinical characteristics of patients who underwent graft nephrectomy according to the time after renal transplantation. Methods From 2005 to 2012, 42 patients underwent graft nephrectomy after transplant failure. We divided these patients into early (n = 17) and late graft nephrectomy (n = 25) groups based on graft survival to 6 months, comparing their causes for nephrectomy and clinical characteristics. Results The patients included 29 men and 13 women, with an overall mean age of 45 years (range, 10-71 years). The main causes for early and late graft nephrectomy were irreversible acute rejection (71{\%}) and graft intolerance syndrome (95{\%}), respectively. The clinical characteristics did not significantly differ between the early and late graft nephrectomy groups except for operative-related complications. Bleeding was more common among patients who underwent early (n = 10) versus late (n = 3) graft nephrectomy (59{\%} vs 12{\%}; P =.01). Of the 10 patients with perioperative bleeding, 8 had a bleeding tendency, such as low platelet count or prolonged prothrombin time at the time of the operation. These complications occurred after antirejection therapy involving plasma exchange or antithymocyte globulin treatment. Allograft nephrectomy was associated with a mortality rate of 2.38{\%}. Conclusions The cause for graft nephrectomy and type of perioperative complication differed according to timing of graft nephrectomy. Antirejection therapy appeared to contribute to postoperative complications such as bleeding.",
author = "Sun, {I. O.} and Hong, {Y. A.} and Park, {H. S.} and Choi, {S. R.} and Chung, {B. H.} and Kim, {J. I.} and Choi, {B. S.} and Park, {C. W.} and YuSeun Kim and Moon, {I. S.} and Yang, {C. W.}",
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Sun, IO, Hong, YA, Park, HS, Choi, SR, Chung, BH, Kim, JI, Choi, BS, Park, CW, Kim, Y, Moon, IS & Yang, CW 2013, 'Comparison of the clinical characteristics of renal transplant recipients who underwent early versus late graft nephrectomy', Transplantation Proceedings, vol. 45, no. 8, pp. 2953-2956. https://doi.org/10.1016/j.transproceed.2013.08.054

Comparison of the clinical characteristics of renal transplant recipients who underwent early versus late graft nephrectomy. / Sun, I. O.; Hong, Y. A.; Park, H. S.; Choi, S. R.; Chung, B. H.; Kim, J. I.; Choi, B. S.; Park, C. W.; Kim, YuSeun; Moon, I. S.; Yang, C. W.

In: Transplantation Proceedings, Vol. 45, No. 8, 01.10.2013, p. 2953-2956.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of the clinical characteristics of renal transplant recipients who underwent early versus late graft nephrectomy

AU - Sun, I. O.

AU - Hong, Y. A.

AU - Park, H. S.

AU - Choi, S. R.

AU - Chung, B. H.

AU - Kim, J. I.

AU - Choi, B. S.

AU - Park, C. W.

AU - Kim, YuSeun

AU - Moon, I. S.

AU - Yang, C. W.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - AbstractBackground Graft nephrectomy is the last-resort option for renal transplant recipients. The aim of this study was to compare the clinical characteristics of patients who underwent graft nephrectomy according to the time after renal transplantation. Methods From 2005 to 2012, 42 patients underwent graft nephrectomy after transplant failure. We divided these patients into early (n = 17) and late graft nephrectomy (n = 25) groups based on graft survival to 6 months, comparing their causes for nephrectomy and clinical characteristics. Results The patients included 29 men and 13 women, with an overall mean age of 45 years (range, 10-71 years). The main causes for early and late graft nephrectomy were irreversible acute rejection (71%) and graft intolerance syndrome (95%), respectively. The clinical characteristics did not significantly differ between the early and late graft nephrectomy groups except for operative-related complications. Bleeding was more common among patients who underwent early (n = 10) versus late (n = 3) graft nephrectomy (59% vs 12%; P =.01). Of the 10 patients with perioperative bleeding, 8 had a bleeding tendency, such as low platelet count or prolonged prothrombin time at the time of the operation. These complications occurred after antirejection therapy involving plasma exchange or antithymocyte globulin treatment. Allograft nephrectomy was associated with a mortality rate of 2.38%. Conclusions The cause for graft nephrectomy and type of perioperative complication differed according to timing of graft nephrectomy. Antirejection therapy appeared to contribute to postoperative complications such as bleeding.

AB - AbstractBackground Graft nephrectomy is the last-resort option for renal transplant recipients. The aim of this study was to compare the clinical characteristics of patients who underwent graft nephrectomy according to the time after renal transplantation. Methods From 2005 to 2012, 42 patients underwent graft nephrectomy after transplant failure. We divided these patients into early (n = 17) and late graft nephrectomy (n = 25) groups based on graft survival to 6 months, comparing their causes for nephrectomy and clinical characteristics. Results The patients included 29 men and 13 women, with an overall mean age of 45 years (range, 10-71 years). The main causes for early and late graft nephrectomy were irreversible acute rejection (71%) and graft intolerance syndrome (95%), respectively. The clinical characteristics did not significantly differ between the early and late graft nephrectomy groups except for operative-related complications. Bleeding was more common among patients who underwent early (n = 10) versus late (n = 3) graft nephrectomy (59% vs 12%; P =.01). Of the 10 patients with perioperative bleeding, 8 had a bleeding tendency, such as low platelet count or prolonged prothrombin time at the time of the operation. These complications occurred after antirejection therapy involving plasma exchange or antithymocyte globulin treatment. Allograft nephrectomy was associated with a mortality rate of 2.38%. Conclusions The cause for graft nephrectomy and type of perioperative complication differed according to timing of graft nephrectomy. Antirejection therapy appeared to contribute to postoperative complications such as bleeding.

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