Comparison of the clinical features and outcomes of gallbladder neuroendocrine carcinoma with those of adenocarcinoma: A propensity score-matched analysis

Min Young Do, Sung Ill Jang, Hua Pyong Kang, Eui Joo Kim, Kyong Joo Lee, Go Eun Park, Su Jee Lee, Dong Ki Lee, Sang Myung Woo, Jae Hee Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroendocrine neoplasms (NENs) of the gallbladder (GB) are extremely rare. We aimed to compare the clinical features, disease progression, management, and prognosis of patients with GB-NENs with those of patients with GB-adenocarcinomas (ADCs). A total of 21 patients with GB-NENs and 206 patients with GB-ADCs, treated at three tertiary medical centers between January 2010 and December 2020, were enrolled. Of the 21 patients with GB-NENs, 20 were diagnosed with poorly differentiated small-cell neuroendocrine carcinomas (NECs), and 1 patient had large-cell NEC. All patients presented with advanced stages of cancer with extensive local extension and/or distant metastasis and non-specific symptoms. Tumor-node-metastasis stage IIIB and IV (A/B) tumors were found in 6 and 15 (1/14) patients, respectively. Nine patients with GB-NEC who underwent surgical resection had a significantly better progression-free survival (PFS) than those who did not undergo surgery. After a propensity score matching with a 1:1 ratio using the American Joint Committee on Cancer stage, age, sex, and operation status, 19 pairs of patients were included. Compared with stage-matched patients with GB-ADC, patients with GB-NEC had similar overall survival and PFS. However, as GB-NEC is rarely diagnosed early, further studies investigating methods for the early diagnosis and improvement in the survival of patients with GB-NEC are needed.

Original languageEnglish
Article number4713
JournalCancers
Volume13
Issue number18
DOIs
Publication statusPublished - 2021 Sep

Bibliographical note

Funding Information:
Funding: This work was supported by a faculty research grant from the Yonsei University College of Medicine (Cho Jae Hee, 6-2020-0133) and the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education (Cho Jae Hee, NRF-2017R1D1A1B04034547).

Funding Information:
This work was supported by a faculty research grant from the Yonsei University College of Medicine (Cho Jae Hee, 6-2020-0133) and the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education (Cho Jae Hee, NRF-2017R1D1A1B04034547). We would like to thank the Biostatistics Collaboration Unit.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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