Comparison of the clinical features of apical hypertrophic cardiomyopathy versus asymmetric septal hypertrophy in Korea

Hyun Suk Yang, Jae Kwan Song, Jong Min Song, Duk Hyun Kang, Cheol Whan Lee, Myeong Ki Hong, Jae Joong Kim, Seong Wook Park, Seung Jung Park

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Background: We sought to test whether patients with apical hypertrophic cardiomyopathy (APH) have different clinical features compared to those with typical asymmetric septal hypertrophy (ASH). Methods: Among 32,534 patients who underwent routine echocardiography at Asan Medical Center from January 2000 to December 2001, 305 patients (0.9%), who were finally diagnosed with hypertrophic cardiomyopathy (HCMP), were evaluated. The type of HCMP was classified according to the echocardiographic findings. Results: ASH was the most frequent type (n=160, 53%, group I), and APH was the second most frequent (n=91, 30%, group II). Mean age (60.8±10 vs. 48.2±14 years, p<0.001) and prevalence of hypertension (32% vs. 19%, p=0.022) were significantly higher in group II than in group I. Family history of HCMP (4.4% vs. 0% p=0.043) and sudden cardiac death (8.8% vs. 1.1% p=0.014) was more prevalent in group I. During the follow-up period of 32.0± 37.2 months, cardiac events occurred at a significantly higher rate in group I (25.5% vs. 8.8%, p=0.003). Conclusion: APH comprises a significant proportion of HCMP in Korea and patients with APH show different clinical features compared to those with ASH.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalKorean Journal of Internal Medicine
Issue number2
Publication statusPublished - 2005 Jan 1


All Science Journal Classification (ASJC) codes

  • Internal Medicine

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