Comparison of the clinical implications among five different nutritional indices in patients with lupus nephritis

Sung Soo Ahn, Juyoung Yoo, Seung Min Jung, Jason Jungsik Song, Yong Beom Park, Sang Won Lee

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Abstract

Systemic lupus erythematosus (SLE) is characterized with aberrant responses in the immune systems and lupus nephritis (LN) is one of the most serious complications of SLE. This study evaluated the clinical significance of different nutritional indices in 207 renal biopsy-proven LN patients. The clinical and laboratory data were reviewed, and five different nutritional indices were calculated: (i) Controlling nutritional status (CONUT) score; (ii) prognostic nutritional index (PNI); (iii) nutritional risk index; (iv) neutrophil-to-lymphocyte ratio; and (v) body mass index. The factors associated with end-stage renal failure (ESRF) were assessed using a Cox-proportional hazard analysis. The patients with ESRF had significantly lower median PNI (31.1 vs. 34.7, p = 0.012) than those without ESRF at baseline. The CONUT score and PNI had the highest correlation between the SLE disease activity index-2000 (r = 0.467 and p = −0.356, all p < 0.001) and was significantly associated with SLE activity-related measures. In the Cox-proportional hazard analysis, PNI (odds ratio 0.925, 95% confidence interval 0.865–0.989, p = 0.022) was independently associated with ESRF along with creatinine and chronicity index, and the renal survival rate was significantly lower in patients with PNI ≤35.41 than in those with PNI >35.41 (p = 0.003). Among nutritional indices, the CONUT score and PNI better correlated with disease activity and PNI was associated with ESRF.

Original languageEnglish
Article number1456
JournalNutrients
Volume11
Issue number7
DOIs
Publication statusPublished - 2019 Jul

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nephritis
Nutrition Assessment
Lupus Nephritis
nutrition assessment
renal failure
lupus erythematosus
Chronic Kidney Failure
Nutritional Status
nutritional status
Systemic Lupus Erythematosus
hazard characterization
body mass index
immune system
neutrophils
biopsy
clinical trials
lymphocytes
Immune System
kidneys
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Ahn, Sung Soo ; Yoo, Juyoung ; Jung, Seung Min ; Song, Jason Jungsik ; Park, Yong Beom ; Lee, Sang Won. / Comparison of the clinical implications among five different nutritional indices in patients with lupus nephritis. In: Nutrients. 2019 ; Vol. 11, No. 7.
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Comparison of the clinical implications among five different nutritional indices in patients with lupus nephritis. / Ahn, Sung Soo; Yoo, Juyoung; Jung, Seung Min; Song, Jason Jungsik; Park, Yong Beom; Lee, Sang Won.

In: Nutrients, Vol. 11, No. 7, 1456, 07.2019.

Research output: Contribution to journalArticle

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