Comparison of the effect of preinterventional arterial remodeling on intimal hyperplasia after implantation of a sirolimus- or paclitaxel-eluting stent

Woong Chol Kang, Taehoon Ahn, Chan Il Moon, Kyunghoon Lee, Seung Hwan Han, Eak Kyun Shin, Jung Sun Kim, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Byoung Keuk Kim, Seong Jin Oh, Dong Woon Jeon, Joo Young Yang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: We compared the effect of arterial remodeling on intimal hyperplasia (IH) after the implantation of a sirolimus-eluting stent (SES) and a paclitaxel-eluting stent (PES). Methods: The study population consisted of patients with positive or intermediate remodeling and negative remodeling. Results: Sixty-nine patients had positive or intermediate remodeling and 107 patients had negative remodeling. At follow-up, late loss was significantly larger (0.58 ± 0.65 vs. 0.38 ± 0.55 mm; p = 0.026) in the patients with positive or intermediate remodeling. The IH volume (22.6 ± 26.2 vs. 12.4 ± 17.4 mm3; p = 0.002) and the percent IH (12.9 ± 14.8 vs. 7.0 ± 9.6%; p = 0.002) were significantly higher in the patients with positive or intermediate remodeling. Compared to negative remodeling, the IH volume was higher in the PES patients with positive or intermediate remodeling, but this difference was not noted in the SES patients. Multiple-regression analysis revealed that arterial remodeling was a significant independent variable for predicting IH volume in the PES patients (p = 0.018). A positive correlation was found between the remodeling index and the IH volume in the PES patients (r = 0.234, p = 0.028), but not in the SES patients. Conclusions: This prospective observational intravascular ultrasound study showed that drug-eluting stents may have a different effect on reducing IH accumulation in lesions with preinterventional positive remodeling characteristics which may be related to the different properties of the drug and delivery platform.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalCardiology
Volume116
Issue number2
DOIs
Publication statusPublished - 2010 Jul 1

Fingerprint

Tunica Intima
Sirolimus
Paclitaxel
Hyperplasia
Stents
Drug-Eluting Stents
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Kang, Woong Chol ; Ahn, Taehoon ; Moon, Chan Il ; Lee, Kyunghoon ; Han, Seung Hwan ; Shin, Eak Kyun ; Kim, Jung Sun ; Ko, Young Guk ; Choi, Donghoon ; Jang, Yangsoo ; Kim, Byoung Keuk ; Oh, Seong Jin ; Jeon, Dong Woon ; Yang, Joo Young. / Comparison of the effect of preinterventional arterial remodeling on intimal hyperplasia after implantation of a sirolimus- or paclitaxel-eluting stent. In: Cardiology. 2010 ; Vol. 116, No. 2. pp. 117-122.
@article{b04340374b51458695b3a29760079231,
title = "Comparison of the effect of preinterventional arterial remodeling on intimal hyperplasia after implantation of a sirolimus- or paclitaxel-eluting stent",
abstract = "Background: We compared the effect of arterial remodeling on intimal hyperplasia (IH) after the implantation of a sirolimus-eluting stent (SES) and a paclitaxel-eluting stent (PES). Methods: The study population consisted of patients with positive or intermediate remodeling and negative remodeling. Results: Sixty-nine patients had positive or intermediate remodeling and 107 patients had negative remodeling. At follow-up, late loss was significantly larger (0.58 ± 0.65 vs. 0.38 ± 0.55 mm; p = 0.026) in the patients with positive or intermediate remodeling. The IH volume (22.6 ± 26.2 vs. 12.4 ± 17.4 mm3; p = 0.002) and the percent IH (12.9 ± 14.8 vs. 7.0 ± 9.6{\%}; p = 0.002) were significantly higher in the patients with positive or intermediate remodeling. Compared to negative remodeling, the IH volume was higher in the PES patients with positive or intermediate remodeling, but this difference was not noted in the SES patients. Multiple-regression analysis revealed that arterial remodeling was a significant independent variable for predicting IH volume in the PES patients (p = 0.018). A positive correlation was found between the remodeling index and the IH volume in the PES patients (r = 0.234, p = 0.028), but not in the SES patients. Conclusions: This prospective observational intravascular ultrasound study showed that drug-eluting stents may have a different effect on reducing IH accumulation in lesions with preinterventional positive remodeling characteristics which may be related to the different properties of the drug and delivery platform.",
author = "Kang, {Woong Chol} and Taehoon Ahn and Moon, {Chan Il} and Kyunghoon Lee and Han, {Seung Hwan} and Shin, {Eak Kyun} and Kim, {Jung Sun} and Ko, {Young Guk} and Donghoon Choi and Yangsoo Jang and Kim, {Byoung Keuk} and Oh, {Seong Jin} and Jeon, {Dong Woon} and Yang, {Joo Young}",
year = "2010",
month = "7",
day = "1",
doi = "10.1159/000317071",
language = "English",
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Kang, WC, Ahn, T, Moon, CI, Lee, K, Han, SH, Shin, EK, Kim, JS, Ko, YG, Choi, D, Jang, Y, Kim, BK, Oh, SJ, Jeon, DW & Yang, JY 2010, 'Comparison of the effect of preinterventional arterial remodeling on intimal hyperplasia after implantation of a sirolimus- or paclitaxel-eluting stent', Cardiology, vol. 116, no. 2, pp. 117-122. https://doi.org/10.1159/000317071

Comparison of the effect of preinterventional arterial remodeling on intimal hyperplasia after implantation of a sirolimus- or paclitaxel-eluting stent. / Kang, Woong Chol; Ahn, Taehoon; Moon, Chan Il; Lee, Kyunghoon; Han, Seung Hwan; Shin, Eak Kyun; Kim, Jung Sun; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo; Kim, Byoung Keuk; Oh, Seong Jin; Jeon, Dong Woon; Yang, Joo Young.

In: Cardiology, Vol. 116, No. 2, 01.07.2010, p. 117-122.

Research output: Contribution to journalArticle

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T1 - Comparison of the effect of preinterventional arterial remodeling on intimal hyperplasia after implantation of a sirolimus- or paclitaxel-eluting stent

AU - Kang, Woong Chol

AU - Ahn, Taehoon

AU - Moon, Chan Il

AU - Lee, Kyunghoon

AU - Han, Seung Hwan

AU - Shin, Eak Kyun

AU - Kim, Jung Sun

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Jang, Yangsoo

AU - Kim, Byoung Keuk

AU - Oh, Seong Jin

AU - Jeon, Dong Woon

AU - Yang, Joo Young

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Background: We compared the effect of arterial remodeling on intimal hyperplasia (IH) after the implantation of a sirolimus-eluting stent (SES) and a paclitaxel-eluting stent (PES). Methods: The study population consisted of patients with positive or intermediate remodeling and negative remodeling. Results: Sixty-nine patients had positive or intermediate remodeling and 107 patients had negative remodeling. At follow-up, late loss was significantly larger (0.58 ± 0.65 vs. 0.38 ± 0.55 mm; p = 0.026) in the patients with positive or intermediate remodeling. The IH volume (22.6 ± 26.2 vs. 12.4 ± 17.4 mm3; p = 0.002) and the percent IH (12.9 ± 14.8 vs. 7.0 ± 9.6%; p = 0.002) were significantly higher in the patients with positive or intermediate remodeling. Compared to negative remodeling, the IH volume was higher in the PES patients with positive or intermediate remodeling, but this difference was not noted in the SES patients. Multiple-regression analysis revealed that arterial remodeling was a significant independent variable for predicting IH volume in the PES patients (p = 0.018). A positive correlation was found between the remodeling index and the IH volume in the PES patients (r = 0.234, p = 0.028), but not in the SES patients. Conclusions: This prospective observational intravascular ultrasound study showed that drug-eluting stents may have a different effect on reducing IH accumulation in lesions with preinterventional positive remodeling characteristics which may be related to the different properties of the drug and delivery platform.

AB - Background: We compared the effect of arterial remodeling on intimal hyperplasia (IH) after the implantation of a sirolimus-eluting stent (SES) and a paclitaxel-eluting stent (PES). Methods: The study population consisted of patients with positive or intermediate remodeling and negative remodeling. Results: Sixty-nine patients had positive or intermediate remodeling and 107 patients had negative remodeling. At follow-up, late loss was significantly larger (0.58 ± 0.65 vs. 0.38 ± 0.55 mm; p = 0.026) in the patients with positive or intermediate remodeling. The IH volume (22.6 ± 26.2 vs. 12.4 ± 17.4 mm3; p = 0.002) and the percent IH (12.9 ± 14.8 vs. 7.0 ± 9.6%; p = 0.002) were significantly higher in the patients with positive or intermediate remodeling. Compared to negative remodeling, the IH volume was higher in the PES patients with positive or intermediate remodeling, but this difference was not noted in the SES patients. Multiple-regression analysis revealed that arterial remodeling was a significant independent variable for predicting IH volume in the PES patients (p = 0.018). A positive correlation was found between the remodeling index and the IH volume in the PES patients (r = 0.234, p = 0.028), but not in the SES patients. Conclusions: This prospective observational intravascular ultrasound study showed that drug-eluting stents may have a different effect on reducing IH accumulation in lesions with preinterventional positive remodeling characteristics which may be related to the different properties of the drug and delivery platform.

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