Comparison of the effectiveness of sirolimus- and paclitaxel-eluting stents for small coronary artery lesions

Kyoung Ha Park, Seong Wook Park, Myeong Ki Hong, Young Hak Kim, Bong Ki Lee, Duk Woo Park, Bong Ryong Choi, Mi Jeong Kim, Kyoung Min Park, Cheol Whan Lee, Sang Sig Cheong, Jae Joong Kim, Seung Jung Park

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Abstract

Background: The sirolimus-eluting stent (SES) and the paclitaxel-eluting stent (PES) reduce restenosis in small coronary artery lesions. However, it is not clear which of these stents is superior in terms of clinical outcomes. Methods: The authors retrospectively examined 197 patients with 245 de novo small coronary artery lesions (≤2.75 mm) that were treated with either the SES (156 lesions) or the PES (89 lesions). Six-month angiographic restenosis rates and the 9-month target lesion revascularization (TLR) rates were compared between the two groups. Results: In terms of baseline clinical and angiographic parameters, the two groups well matched together. Six-month angiographie follow-up was performed on 170 patients (86.3%), comprising 135 SES lesions (86.5%) and 76 PES lesions (85.4%). At 6-month angiographic follow-up, the late lumen loss was less in the SES group than in the PES group (0.29 ± 0.42 vs. 0.69 ± 0.63 mm, P < 0.01). Therefore, the SES group showed a lower rate of angiographic restenosis than the PES group (6.7% vs. 27.7%, P < 0.01). At 9 months there were no deaths or myocardial infarctions in either group. The 9-month TLR rate was lower in the SES group than in the PES group (3.3% vs. 14.4%, P < 0.01). The Kaplan-Meier estimate of freedom from TLR at 9 months was 96.7% for the SES patients and 86.5% for the PES patients (P < 0.01). Conclusions: The SES treatment may be superior to the PES treatment in terms of long-term clinical and angiographic outcomes in patients with small coronary artery lesions.

Original languageEnglish
Pages (from-to)589-594
Number of pages6
JournalCatheterization and Cardiovascular Interventions
Volume67
Issue number4
DOIs
Publication statusPublished - 2006 Apr 1

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All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Park, K. H., Park, S. W., Hong, M. K., Kim, Y. H., Lee, B. K., Park, D. W., Choi, B. R., Kim, M. J., Park, K. M., Lee, C. W., Cheong, S. S., Kim, J. J., & Park, S. J. (2006). Comparison of the effectiveness of sirolimus- and paclitaxel-eluting stents for small coronary artery lesions. Catheterization and Cardiovascular Interventions, 67(4), 589-594. https://doi.org/10.1002/ccd.20700