We compared the haemodynamic effects of nicardipine and sodium nitroprusside after coronary artery bypass graft surgery. When post-surgery systolic blood pressure reached > 150 mmHg, patients were randomly given nicardipine (N group, n = 26) or sodium nitroprusside (S group, n = 21). The drugs were infused at a rate of 2 μg/kg per min for 10 min. If the target blood pressure (120 - 140 mmHg) was not achieved, the infusion rate was increased by 1 μg/kg per min every 10 min. Cardiac and stroke volume indices had increased significantly in the N group after 10 min and in both groups after 60 min. The infusion duration and total dose of drug were significantly lower in the N group compared with the S group. Nicardipine infusion controlled post-operative hypertension more rapidly and was superior to sodium nitroprusside in maintaining left ventricular performance immediately after drug infusion.
All Science Journal Classification (ASJC) codes
- Cell Biology
- Biochemistry, medical