Comparison of the planned one- and elective two-stent techniques in patients with coronary bifurcation lesions with or without acute coronary syndrome from the COBIS II Registry

Min Chul Kim, Youngkeun Ahn, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Hyeon Cheol Gwon, Hyo Soo Kim, Seung Woon Rha, Jung Han Yoon, Yangsoo Jang, Seung Jea Tahk, Ki Bae Seung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: To evaluate the impacts of stent techniques on long-term clinical outcomes after percutaneous coronary intervention (PCI) using drug-eluting stents (DES) for coronary bifurcation lesions in patients with or without acute coronary syndrome (ACS). Background: Few studies have investigated the impacts of stent techniques for treating coronary bifurcation lesions in patients with and without ACS. Methods: This multicenter registry enrolled 2,897 patients undergoing PCI with DES for coronary bifurcation lesions. We investigated the impacts of planned one-stent and elective two-stent techniques in patients with (n = 1,798) and those without (n = 1,099) ACS. Primary endpoint was the incidence of 3-year target-lesion failure (TLF), defined as a composite of cardiac death, spontaneous myocardial infarction, and target-lesion revascularization. Results: The planned one-stent technique reduced TLF rate compared to elective two-stent technique in the ACS cohort (hazard ratio [HR] 0.49; 95% confidence interval [CI] 0.34–0.74; P = 0.001), and not in the non-ACS cohort (HR 0.61; 95% CI 0.35–1.06; P = 0.079). After propensity score matching, the planned one-stent technique had a significantly lower TLF rate (HR 0.47; 95% CI 0.29–0.74; P = 0.001) in patients with ACS, and it also showed a trend toward lower TLF rate with the planned one-stent technique in patients without ACS (9.0 vs. 14.5%, HR 0.59; 95% CI 0.32–1.14; P = 0.116). Conclusions: Planned one-stenting reduced TLF in patients with ACS and it also might be beneficial in those without ACS for the treatment of coronary bifurcation lesions.

Original languageEnglish
Pages (from-to)1050-1060
Number of pages11
JournalCatheterization and Cardiovascular Interventions
Volume92
Issue number6
DOIs
Publication statusPublished - 2018 Nov 15

Fingerprint

Acute Coronary Syndrome
Stents
Registries
Confidence Intervals
Drug-Eluting Stents
Percutaneous Coronary Intervention
Propensity Score
Myocardial Infarction
Incidence

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Kim, Min Chul ; Ahn, Youngkeun ; Sun Sim, Doo ; Joon Hong, Young ; Han Kim, Ju ; Ho Jeong, Myung ; Gwon, Hyeon Cheol ; Kim, Hyo Soo ; Rha, Seung Woon ; Yoon, Jung Han ; Jang, Yangsoo ; Tahk, Seung Jea ; Seung, Ki Bae. / Comparison of the planned one- and elective two-stent techniques in patients with coronary bifurcation lesions with or without acute coronary syndrome from the COBIS II Registry. In: Catheterization and Cardiovascular Interventions. 2018 ; Vol. 92, No. 6. pp. 1050-1060.
@article{d80769ae99214820b1811e141a0f6fe5,
title = "Comparison of the planned one- and elective two-stent techniques in patients with coronary bifurcation lesions with or without acute coronary syndrome from the COBIS II Registry",
abstract = "Objectives: To evaluate the impacts of stent techniques on long-term clinical outcomes after percutaneous coronary intervention (PCI) using drug-eluting stents (DES) for coronary bifurcation lesions in patients with or without acute coronary syndrome (ACS). Background: Few studies have investigated the impacts of stent techniques for treating coronary bifurcation lesions in patients with and without ACS. Methods: This multicenter registry enrolled 2,897 patients undergoing PCI with DES for coronary bifurcation lesions. We investigated the impacts of planned one-stent and elective two-stent techniques in patients with (n = 1,798) and those without (n = 1,099) ACS. Primary endpoint was the incidence of 3-year target-lesion failure (TLF), defined as a composite of cardiac death, spontaneous myocardial infarction, and target-lesion revascularization. Results: The planned one-stent technique reduced TLF rate compared to elective two-stent technique in the ACS cohort (hazard ratio [HR] 0.49; 95{\%} confidence interval [CI] 0.34–0.74; P = 0.001), and not in the non-ACS cohort (HR 0.61; 95{\%} CI 0.35–1.06; P = 0.079). After propensity score matching, the planned one-stent technique had a significantly lower TLF rate (HR 0.47; 95{\%} CI 0.29–0.74; P = 0.001) in patients with ACS, and it also showed a trend toward lower TLF rate with the planned one-stent technique in patients without ACS (9.0 vs. 14.5{\%}, HR 0.59; 95{\%} CI 0.32–1.14; P = 0.116). Conclusions: Planned one-stenting reduced TLF in patients with ACS and it also might be beneficial in those without ACS for the treatment of coronary bifurcation lesions.",
author = "Kim, {Min Chul} and Youngkeun Ahn and {Sun Sim}, Doo and {Joon Hong}, Young and {Han Kim}, Ju and {Ho Jeong}, Myung and Gwon, {Hyeon Cheol} and Kim, {Hyo Soo} and Rha, {Seung Woon} and Yoon, {Jung Han} and Yangsoo Jang and Tahk, {Seung Jea} and Seung, {Ki Bae}",
year = "2018",
month = "11",
day = "15",
doi = "10.1002/ccd.27551",
language = "English",
volume = "92",
pages = "1050--1060",
journal = "Catheterization and Cardiovascular Interventions",
issn = "1522-1946",
publisher = "Wiley-Liss Inc.",
number = "6",

}

Comparison of the planned one- and elective two-stent techniques in patients with coronary bifurcation lesions with or without acute coronary syndrome from the COBIS II Registry. / Kim, Min Chul; Ahn, Youngkeun; Sun Sim, Doo; Joon Hong, Young; Han Kim, Ju; Ho Jeong, Myung; Gwon, Hyeon Cheol; Kim, Hyo Soo; Rha, Seung Woon; Yoon, Jung Han; Jang, Yangsoo; Tahk, Seung Jea; Seung, Ki Bae.

In: Catheterization and Cardiovascular Interventions, Vol. 92, No. 6, 15.11.2018, p. 1050-1060.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of the planned one- and elective two-stent techniques in patients with coronary bifurcation lesions with or without acute coronary syndrome from the COBIS II Registry

AU - Kim, Min Chul

AU - Ahn, Youngkeun

AU - Sun Sim, Doo

AU - Joon Hong, Young

AU - Han Kim, Ju

AU - Ho Jeong, Myung

AU - Gwon, Hyeon Cheol

AU - Kim, Hyo Soo

AU - Rha, Seung Woon

AU - Yoon, Jung Han

AU - Jang, Yangsoo

AU - Tahk, Seung Jea

AU - Seung, Ki Bae

PY - 2018/11/15

Y1 - 2018/11/15

N2 - Objectives: To evaluate the impacts of stent techniques on long-term clinical outcomes after percutaneous coronary intervention (PCI) using drug-eluting stents (DES) for coronary bifurcation lesions in patients with or without acute coronary syndrome (ACS). Background: Few studies have investigated the impacts of stent techniques for treating coronary bifurcation lesions in patients with and without ACS. Methods: This multicenter registry enrolled 2,897 patients undergoing PCI with DES for coronary bifurcation lesions. We investigated the impacts of planned one-stent and elective two-stent techniques in patients with (n = 1,798) and those without (n = 1,099) ACS. Primary endpoint was the incidence of 3-year target-lesion failure (TLF), defined as a composite of cardiac death, spontaneous myocardial infarction, and target-lesion revascularization. Results: The planned one-stent technique reduced TLF rate compared to elective two-stent technique in the ACS cohort (hazard ratio [HR] 0.49; 95% confidence interval [CI] 0.34–0.74; P = 0.001), and not in the non-ACS cohort (HR 0.61; 95% CI 0.35–1.06; P = 0.079). After propensity score matching, the planned one-stent technique had a significantly lower TLF rate (HR 0.47; 95% CI 0.29–0.74; P = 0.001) in patients with ACS, and it also showed a trend toward lower TLF rate with the planned one-stent technique in patients without ACS (9.0 vs. 14.5%, HR 0.59; 95% CI 0.32–1.14; P = 0.116). Conclusions: Planned one-stenting reduced TLF in patients with ACS and it also might be beneficial in those without ACS for the treatment of coronary bifurcation lesions.

AB - Objectives: To evaluate the impacts of stent techniques on long-term clinical outcomes after percutaneous coronary intervention (PCI) using drug-eluting stents (DES) for coronary bifurcation lesions in patients with or without acute coronary syndrome (ACS). Background: Few studies have investigated the impacts of stent techniques for treating coronary bifurcation lesions in patients with and without ACS. Methods: This multicenter registry enrolled 2,897 patients undergoing PCI with DES for coronary bifurcation lesions. We investigated the impacts of planned one-stent and elective two-stent techniques in patients with (n = 1,798) and those without (n = 1,099) ACS. Primary endpoint was the incidence of 3-year target-lesion failure (TLF), defined as a composite of cardiac death, spontaneous myocardial infarction, and target-lesion revascularization. Results: The planned one-stent technique reduced TLF rate compared to elective two-stent technique in the ACS cohort (hazard ratio [HR] 0.49; 95% confidence interval [CI] 0.34–0.74; P = 0.001), and not in the non-ACS cohort (HR 0.61; 95% CI 0.35–1.06; P = 0.079). After propensity score matching, the planned one-stent technique had a significantly lower TLF rate (HR 0.47; 95% CI 0.29–0.74; P = 0.001) in patients with ACS, and it also showed a trend toward lower TLF rate with the planned one-stent technique in patients without ACS (9.0 vs. 14.5%, HR 0.59; 95% CI 0.32–1.14; P = 0.116). Conclusions: Planned one-stenting reduced TLF in patients with ACS and it also might be beneficial in those without ACS for the treatment of coronary bifurcation lesions.

UR - http://www.scopus.com/inward/record.url?scp=85044320888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044320888&partnerID=8YFLogxK

U2 - 10.1002/ccd.27551

DO - 10.1002/ccd.27551

M3 - Article

C2 - 29573537

AN - SCOPUS:85044320888

VL - 92

SP - 1050

EP - 1060

JO - Catheterization and Cardiovascular Interventions

JF - Catheterization and Cardiovascular Interventions

SN - 1522-1946

IS - 6

ER -