Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones

Jun Yeon Park, Hwan You, Dahae Lee, Wonsang Huh, Gwi Seo Hwang, Kyoung Tai No, Ki Hyun Kim, Jungyeob Ham, Noriko Yamabe, Younghoon Kim, Ki Sung Kang

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2 Citations (Scopus)

Abstract

The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalBulletin of the Korean Chemical Society
Volume37
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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    Park, J. Y., You, H., Lee, D., Huh, W., Hwang, G. S., No, K. T., Kim, K. H., Ham, J., Yamabe, N., Kim, Y., & Kang, K. S. (2016). Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones. Bulletin of the Korean Chemical Society, 37(1), 52-55. https://doi.org/10.1002/bkcs.10623