Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones

Jun Yeon Park, Hwan You, Dahae Lee, Wonsang Huh, Gwi Seo Hwang, Kyoung Tai No, Ki Hyun Kim, Jungyeob Ham, Noriko Yamabe, Younghoon Kim, Ki Sung Kang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalBulletin of the Korean Chemical Society
Volume37
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Ginsenosides
Metabolites
Endothelial cells
Sapogenins
protopanaxadiol

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Park, Jun Yeon ; You, Hwan ; Lee, Dahae ; Huh, Wonsang ; Hwang, Gwi Seo ; No, Kyoung Tai ; Kim, Ki Hyun ; Ham, Jungyeob ; Yamabe, Noriko ; Kim, Younghoon ; Kang, Ki Sung. / Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones. In: Bulletin of the Korean Chemical Society. 2016 ; Vol. 37, No. 1. pp. 52-55.
@article{72a6a88eb78444bc8a261cac51211e5f,
title = "Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones",
abstract = "The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35{\%}, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.",
author = "Park, {Jun Yeon} and Hwan You and Dahae Lee and Wonsang Huh and Hwang, {Gwi Seo} and No, {Kyoung Tai} and Kim, {Ki Hyun} and Jungyeob Ham and Noriko Yamabe and Younghoon Kim and Kang, {Ki Sung}",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/bkcs.10623",
language = "English",
volume = "37",
pages = "52--55",
journal = "Bulletin of the Korean Chemical Society",
issn = "0253-2964",
publisher = "Korean Chemical Society",
number = "1",

}

Park, JY, You, H, Lee, D, Huh, W, Hwang, GS, No, KT, Kim, KH, Ham, J, Yamabe, N, Kim, Y & Kang, KS 2016, 'Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones', Bulletin of the Korean Chemical Society, vol. 37, no. 1, pp. 52-55. https://doi.org/10.1002/bkcs.10623

Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones. / Park, Jun Yeon; You, Hwan; Lee, Dahae; Huh, Wonsang; Hwang, Gwi Seo; No, Kyoung Tai; Kim, Ki Hyun; Ham, Jungyeob; Yamabe, Noriko; Kim, Younghoon; Kang, Ki Sung.

In: Bulletin of the Korean Chemical Society, Vol. 37, No. 1, 01.01.2016, p. 52-55.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones

AU - Park, Jun Yeon

AU - You, Hwan

AU - Lee, Dahae

AU - Huh, Wonsang

AU - Hwang, Gwi Seo

AU - No, Kyoung Tai

AU - Kim, Ki Hyun

AU - Ham, Jungyeob

AU - Yamabe, Noriko

AU - Kim, Younghoon

AU - Kang, Ki Sung

PY - 2016/1/1

Y1 - 2016/1/1

N2 - The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.

AB - The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.

UR - http://www.scopus.com/inward/record.url?scp=84954176501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954176501&partnerID=8YFLogxK

U2 - 10.1002/bkcs.10623

DO - 10.1002/bkcs.10623

M3 - Article

VL - 37

SP - 52

EP - 55

JO - Bulletin of the Korean Chemical Society

JF - Bulletin of the Korean Chemical Society

SN - 0253-2964

IS - 1

ER -