Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones

Jun Yeon Park; Hwan You; Dahae Lee; Wonsang Huh; Gwi Seo Hwang; Kyoung Tai No; Ki Hyun Kim; Jungyeob Ham; Noriko Yamabe; Younghoon Kim; Ki Sung Kang

doi:10.1002/bkcs.10623

Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones

Jun Yeon Park, Hwan You, Dahae Lee, Wonsang Huh, Gwi Seo Hwang, Kyoung Tai No, Ki Hyun Kim, Jungyeob Ham, Noriko Yamabe, Younghoon Kim, Ki Sung Kang

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.

Original language	English
Pages (from-to)	52-55
Number of pages	4
Journal	Bulletin of the Korean Chemical Society
Volume	37
Issue number	1
DOIs	https://doi.org/10.1002/bkcs.10623
Publication status	Published - 2016 Jan 1

Bibliographical note

Publisher Copyright:
© 2015 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1002/bkcs.10623

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title = "Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones",

abstract = "The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.",

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AU - Park, Jun Yeon

AU - You, Hwan

AU - Lee, Dahae

AU - Huh, Wonsang

AU - Hwang, Gwi Seo

AU - No, Kyoung Tai

AU - Kim, Ki Hyun

AU - Ham, Jungyeob

AU - Yamabe, Noriko

AU - Kim, Younghoon

AU - Kang, Ki Sung

PY - 2016/1/1

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N2 - The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.

AB - The effect of ginsenosides, their metabolites, and aglycones on tube formation in human umbilical vein vascular endothelial cells (HUVEC) was investigated to identify ways to potentially enhance wound healing. Of the tested compounds, sapogenins, aglycones of ginsenosides, promoted tube formation, whereas ginsenosides and their metabolites had no effect or inhibitory effects on tube formation. Treatment of HUVEC at concentrations of 6.25 and 12.5 μM 20(S)-protopanaxadiol (PPD) significantly increased tube formation by 34 and 35%, respectively. PPD also had a pronounced effect on the speed of wound closure in mouse dermal wounds.

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Comparison of the wound-healing effects of ginsenosides, their metabolites, and aglycones

Abstract

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