Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Bing Chun Yan, Joon Ha Park, Sung Koo Kim, Jung Hoon Choi, Choong Hyun Lee, Ki Yeon Yoo, Young-Guen Kwon, Young Myeong Kim, Jong Dai Kim, Moo Ho Won

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.

Original languageEnglish
Pages (from-to)1231-1242
Number of pages12
JournalCellular and Molecular Neurobiology
Volume32
Issue number8
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Glial Cell Line-Derived Neurotrophic Factor
Hippocampal CA1 Region
Gerbillinae
Brain-Derived Neurotrophic Factor
Transient Ischemic Attack
Vascular Endothelial Growth Factor A
Reperfusion
Young Adult
Ischemia
Pyramidal Cells

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Yan, Bing Chun ; Park, Joon Ha ; Kim, Sung Koo ; Choi, Jung Hoon ; Lee, Choong Hyun ; Yoo, Ki Yeon ; Kwon, Young-Guen ; Kim, Young Myeong ; Kim, Jong Dai ; Won, Moo Ho. / Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia. In: Cellular and Molecular Neurobiology. 2012 ; Vol. 32, No. 8. pp. 1231-1242.
@article{e394886546a3409cb895a937df98ea01,
title = "Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.",
abstract = "In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89{\%}) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59{\%} of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.",
author = "Yan, {Bing Chun} and Park, {Joon Ha} and Kim, {Sung Koo} and Choi, {Jung Hoon} and Lee, {Choong Hyun} and Yoo, {Ki Yeon} and Young-Guen Kwon and Kim, {Young Myeong} and Kim, {Jong Dai} and Won, {Moo Ho}",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/s10571-012-9848-9",
language = "English",
volume = "32",
pages = "1231--1242",
journal = "Cellular and Molecular Neurobiology",
issn = "0272-4340",
publisher = "Springer New York",
number = "8",

}

Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia. / Yan, Bing Chun; Park, Joon Ha; Kim, Sung Koo; Choi, Jung Hoon; Lee, Choong Hyun; Yoo, Ki Yeon; Kwon, Young-Guen; Kim, Young Myeong; Kim, Jong Dai; Won, Moo Ho.

In: Cellular and Molecular Neurobiology, Vol. 32, No. 8, 01.01.2012, p. 1231-1242.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

AU - Yan, Bing Chun

AU - Park, Joon Ha

AU - Kim, Sung Koo

AU - Choi, Jung Hoon

AU - Lee, Choong Hyun

AU - Yoo, Ki Yeon

AU - Kwon, Young-Guen

AU - Kim, Young Myeong

AU - Kim, Jong Dai

AU - Won, Moo Ho

PY - 2012/1/1

Y1 - 2012/1/1

N2 - In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.

AB - In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.

UR - http://www.scopus.com/inward/record.url?scp=85028102981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028102981&partnerID=8YFLogxK

U2 - 10.1007/s10571-012-9848-9

DO - 10.1007/s10571-012-9848-9

M3 - Article

C2 - 22552890

AN - SCOPUS:85028102981

VL - 32

SP - 1231

EP - 1242

JO - Cellular and Molecular Neurobiology

JF - Cellular and Molecular Neurobiology

SN - 0272-4340

IS - 8

ER -