Comparison With Conventional Therapies of Repeated Sirolimus-Eluting Stent Implantation for the Treatment of Drug-Eluting Coronary Stent Restenosis

Young Hak Kim, Bong Ki Lee, Duk Woo Park, Kyoung Ha Park, Bong Ryong Choi, Cheol Whan Lee, Myeong Ki Hong, Jae Joong Kim, Seong Wook Park, Seung Jung Park

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Abstract

This study compared the safety and efficacy of repeat percutaneous coronary intervention (PCI) using sirolimus-eluting stents (SESs) with conventional therapies for restenosis after drug-eluting stent placement. Fifty-five consecutive patients with 58 restenotic lesions (31 treated with SESs and 27 treated with paclitaxel-eluting stents) underwent PCI using SESs (33 lesions) or conventional therapies comprising cutting balloon angioplasty alone (11 lesions) or intracoronary brachytherapy (14 lesions). Baseline characteristics were similar for the 2 groups, except for greater edge involvement (75.8% vs 36.0%, p = 0.002) and less stent expansion (0.74 ± 0.17 vs 0.95 ± 0.21, p = 0.006) in the SES group than in the conventional group. The SES group achieved a greater postprocedural luminal gain than the conventional group (1.98 ± 0.50 vs 1.22 ± 0.48 mm, p <0.001). Follow-up angiography showed that late luminal loss (0.27 ± 0.56 vs 0.76 ± 0.84 mm, p = 0.021) and recurrent angiographic restenosis rate (3.6% vs 35.0%, p = 0.006) were lower in the SES group than in the conventional group. The repeated target lesion revascularization-free survival rates at 1 year were 96.7 ± 3.2% for the SES group and 91.7 ± 5.6% for the conventional group (p = 0.399). In conclusion, use of SESs was associated with a lower recurrent restenosis rate compared with conventional therapies.

Original languageEnglish
Pages (from-to)1451-1454
Number of pages4
JournalAmerican Journal of Cardiology
Volume98
Issue number11
DOIs
Publication statusPublished - 2006 Dec 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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