Comparisonof the pathogenesis of SARS-CoV-2 infection inK18-hACE2 miceand Syrian golden hamstermodels

Haengdueng Jeong, Youn Woo Lee, In Ho Park, Hyuna Noh, Sung Hee Kim, Jiseon Kim, Donghun Jeon, Hui Jeong Jang, Jooyeon Oh, Dain On, Chanyang Uhm, Kyungrae Cho, Heeju Oh, Suhyeon Yoon, Jung Seon Seo, Jeong Jin Kim, Sang Hyuk Seok, Yu Jin Lee, Seung Min Hong, Se Hee AnSeo Yeon Kim, Young Been Kim, Ji Yeon Hwang, Hyo Jung Lee, Hong Bin Kim, Dae Gwin Jeong, Daesub Song, Manki Song, Man Seong Park, Kang Seuk Choi, Jun Won Park, Jun Young Seo, Jun Won Yun, Jeon Soo Shin, Ho Young Lee, Ki Taek Nam, Je Kyung Seong

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


SARS-CoV-2, the etiological agentofCOVID-19, causeslife-threatening disease. This novel coronavirusenters host cellsvia the respiratory tract,promoting the formation ofsevere pulmonary lesions andsystemic disease. Few animal models can simulate the clinical signs and pathology ofCOVID-19patients.Diverse preclinical studies using K18-hACE2 mice and Syrian golden hamsters, which are highly permissive toSARS-CoV-2 in therespiratory tract, are emerging; however, the systemic pathogenesis and cellular tropism of these models remain obscure. We intranasally infected K18-hACE2 mice and Syrian golden hamsterswith SARS-CoV-2, and compared the clinical features, pathogenesis, cellular tropism,and infiltrated immune-cellsubsets. In K18-hACE2 mice, SARS-CoV-2 persistently replicated inalveolar cells and causedpulmonary and extra-pulmonary disease, resulting in fataloutcomes. Conversely, in Syrian golden hamsters, transient SARS-CoV-2infectioninbronchial cells causedreversible pulmonary disease,without mortality. Our findings provide comprehensive insightsinto thepathogenic spectrum of COVID-19 using pre-clinical models.

Original languageEnglish
JournalDMM Disease Models and Mechanisms
Issue number11
Publication statusPublished - 2022 Nov

Bibliographical note

Funding Information:
Funding: This project was supported by the Korea Mouse Phenotyping Project (NRF-2016M3A9D5A01952416) and by the Brain Korea 21 PLUS Project for Medical Science at Yonsei University. K.T.N. is supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (Nos. 2016M3A9D5A01952416 and 2021M3H9A1038083).

Publisher Copyright:
© 2022. Published by The Company of Biologists Ltd.

All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Medicine (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)


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