Comparisons of nerve fiber layer thickness measurements between stratus, cirrus, and RTVue OCTs in healthy and glaucomatous eyes

Eun Suk Lee, Sung Yong Kang, Eun Hee Choi, Ji Hyun Kim, Na Rae Kim, Gong Je Seong, chanyun kim

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Abstract

Purpose.: To compare retinal nerve fiber layer (RNFL) measurements obtained by two spectral-domain optical coherence tomographies (SD OCTs; Cirrus-HD OCT and RTVue) and a time domain OCT (TD OCT; Stratus OCT). The diagnostic ability of the three instruments for glaucoma has also been compared. Methods.: One hundred eight open-angle glaucoma patients and 46 normal controls were enrolled. Three OCT scans were repeated to obtain peripapillary RNFL thickness measurements from all participants on the same day. The relationships between RNFL measurements from three OCTs were evaluated with regression analyses. Results.: The thickest RNFL measurements were generally obtained with the RTVue, followed by the Stratus, and finally by the Cirrus OCT (mixed model, p < 0.05). However, the tendency was reversed or no longer present in severe glaucomatous eyes and nasal quadrant maps. Regression analysis between the TD OCT and the two SD OCTs revealed a quadratic relation (linear vs. non-linear, Akaike information criterion, all p < 0.05), whereby RNFL measurements of the TD OCT became exponentially thinner than those by the SD OCTs in thin RNFL thicknesses. Comparing the two SD OCTs, RTVue measured thicker values consistently regardless of the RNFL thickness (pairwise comparisons, p < 0.05). There were no significant differences in the diagnostic ability of all three instruments in average and each quadrants of RNFL thickness (p > 0.05). Conclusions.: Direct comparisons of RNFL thickness measurements among OCT instruments may be misleading as there are considerable differences among devices. The measurement differences between SD OCT and TD OCT differed according to the RNFL thickness and also possibly to severity of the glaucoma. The diagnostic ability of each instrument for glaucoma detection was not significantly different.

Original languageEnglish
Pages (from-to)751-758
Number of pages8
JournalOptometry and Vision Science
Volume88
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1

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Nerve Fibers
Glaucoma
Open Angle Glaucoma
Optical Coherence Tomography
Regression Analysis
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Optometry

Cite this

Lee, Eun Suk ; Kang, Sung Yong ; Choi, Eun Hee ; Kim, Ji Hyun ; Kim, Na Rae ; Seong, Gong Je ; kim, chanyun. / Comparisons of nerve fiber layer thickness measurements between stratus, cirrus, and RTVue OCTs in healthy and glaucomatous eyes. In: Optometry and Vision Science. 2011 ; Vol. 88, No. 6. pp. 751-758.
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Comparisons of nerve fiber layer thickness measurements between stratus, cirrus, and RTVue OCTs in healthy and glaucomatous eyes. / Lee, Eun Suk; Kang, Sung Yong; Choi, Eun Hee; Kim, Ji Hyun; Kim, Na Rae; Seong, Gong Je; kim, chanyun.

In: Optometry and Vision Science, Vol. 88, No. 6, 01.06.2011, p. 751-758.

Research output: Contribution to journalArticle

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T1 - Comparisons of nerve fiber layer thickness measurements between stratus, cirrus, and RTVue OCTs in healthy and glaucomatous eyes

AU - Lee, Eun Suk

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N2 - Purpose.: To compare retinal nerve fiber layer (RNFL) measurements obtained by two spectral-domain optical coherence tomographies (SD OCTs; Cirrus-HD OCT and RTVue) and a time domain OCT (TD OCT; Stratus OCT). The diagnostic ability of the three instruments for glaucoma has also been compared. Methods.: One hundred eight open-angle glaucoma patients and 46 normal controls were enrolled. Three OCT scans were repeated to obtain peripapillary RNFL thickness measurements from all participants on the same day. The relationships between RNFL measurements from three OCTs were evaluated with regression analyses. Results.: The thickest RNFL measurements were generally obtained with the RTVue, followed by the Stratus, and finally by the Cirrus OCT (mixed model, p < 0.05). However, the tendency was reversed or no longer present in severe glaucomatous eyes and nasal quadrant maps. Regression analysis between the TD OCT and the two SD OCTs revealed a quadratic relation (linear vs. non-linear, Akaike information criterion, all p < 0.05), whereby RNFL measurements of the TD OCT became exponentially thinner than those by the SD OCTs in thin RNFL thicknesses. Comparing the two SD OCTs, RTVue measured thicker values consistently regardless of the RNFL thickness (pairwise comparisons, p < 0.05). There were no significant differences in the diagnostic ability of all three instruments in average and each quadrants of RNFL thickness (p > 0.05). Conclusions.: Direct comparisons of RNFL thickness measurements among OCT instruments may be misleading as there are considerable differences among devices. The measurement differences between SD OCT and TD OCT differed according to the RNFL thickness and also possibly to severity of the glaucoma. The diagnostic ability of each instrument for glaucoma detection was not significantly different.

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