Complement-Fixing Abilities and IgG Subclasses of Autoantibodies in Epidermolysis Bullosa Acquisita

Heun Jung Cho, Il Joo Lee, Soo Chan Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11%) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalYonsei medical journal
Volume39
Issue number4
DOIs
Publication statusPublished - 1998 Jan 1

Fingerprint

Epidermolysis Bullosa Acquisita
Autoantibodies
Immunoglobulin G
Collagen Type VII
Complement Activation
Blister
Serum
Inflammation

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Epidermolysis bullosa acquisita (EBA) is an autoimmune-mediated subepidermal bullous disease in which the target of the autoantibodies is type VII collagen, a major component of anchoring fibrils. The purpose of this study was to evaluate the complement-fixing abilities and IgG subclass distribution of autoantibodies in EBA, and to also attempt to investigate the relation between inflammation, complement fixation and IgG subclass distribution in EBA patients. Only 2 sera of 18 patients (11{\%}) showed weak complement-fixing abilities. IgG1 and IgG4 were the most frequently and intensely stained IgG subclasses in EBA sera. We could not find any relationship between the clinico-pathologic types, complement-fixing abilities and IgG subclasses in EBA. These results suggested that complement activation may not be a key factor of bulla formation in EBA.",
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Complement-Fixing Abilities and IgG Subclasses of Autoantibodies in Epidermolysis Bullosa Acquisita. / Cho, Heun Jung; Lee, Il Joo; Kim, Soo Chan.

In: Yonsei medical journal, Vol. 39, No. 4, 01.01.1998, p. 339-344.

Research output: Contribution to journalArticle

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