Complementarity between distance- and probability-based methods of gene neighbourhood identification for pathway reconstruction

Junha Shin, Tak Lee, Hanhae Kim, Insuk Lee

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Identifying gene neighbourhoods using either distance- or probability-based measures has proven effective in retrieving co-functional links. We report that these two approaches are highly complementary, with differential sensitivity for the core pathway links. We demonstrate that integrating these measures improves prediction of both pathways and phenotypes.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalMolecular BioSystems
Volume10
Issue number1
DOIs
Publication statusPublished - 2014 Jan

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Biology

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