Complete genome sequence of the bacteriophage YMC/09/04/R1988 MRSA BP

A lytic phage from a methicillin-resistant Staphylococcus aureus isolate

Jongsoo Jeon, Roshan D'Souza, Sung Kuk Hong, Yangsoon Lee, DongEun Yong, Jongrak Choi, Kyungwon Lee, Yunsop Chong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is an increasing cause of serious infection, both in the community and hospital settings. Despite sophisticated strategies and efforts, the antibiotic options for treating MRSA infection have been narrowed due to the limited number of newly developed antimicrobials. Herein, we analyze the completely sequenced genome of a novel virulent phage YMC/09/04/R1988 MRSA BP as a potential alternative anti-MRSA agent, which lysed clinical isolates from a patient admitted to the hospital due to hip disarticulation. The phage contains a linear double-stranded DNA genome of 44 459 bp in length, with 33.37% GC content, 62 predicted open reading frames (ORFs), and annotated functions of only 23 ORFs that are associated with structural assembly, host lysis, DNA replication, and modification. It showed a broad host range (17 of 30 strains) against MRSA strains in clinical isolates.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalFEMS Microbiology Letters
Volume359
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Methicillin-Resistant Staphylococcus aureus
Bacteriophages
Genome
Open Reading Frames
Disarticulation
Host Specificity
Community Hospital
Base Composition
Infection
DNA Replication
Hip
Anti-Bacterial Agents
DNA

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology
  • Genetics

Cite this

Jeon, Jongsoo ; D'Souza, Roshan ; Hong, Sung Kuk ; Lee, Yangsoon ; Yong, DongEun ; Choi, Jongrak ; Lee, Kyungwon ; Chong, Yunsop. / Complete genome sequence of the bacteriophage YMC/09/04/R1988 MRSA BP : A lytic phage from a methicillin-resistant Staphylococcus aureus isolate. In: FEMS Microbiology Letters. 2014 ; Vol. 359, No. 2. pp. 144-146.
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Complete genome sequence of the bacteriophage YMC/09/04/R1988 MRSA BP : A lytic phage from a methicillin-resistant Staphylococcus aureus isolate. / Jeon, Jongsoo; D'Souza, Roshan; Hong, Sung Kuk; Lee, Yangsoon; Yong, DongEun; Choi, Jongrak; Lee, Kyungwon; Chong, Yunsop.

In: FEMS Microbiology Letters, Vol. 359, No. 2, 01.01.2014, p. 144-146.

Research output: Contribution to journalArticle

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