Complicated intra-abdominal infections worldwide: The definitive data of the CIAOW Study

Massimo Sartelli, Fausto Catena, Luca Ansaloni, Federico Coccolini, Davide Corbella, Ernest E. Moore, Mark Malangoni, George Velmahos, Raul Coimbra, Kaoru Koike, Ari Leppaniemi, Walter Biffl, Zsolt Balogh, Cino Bendinelli, Sanjay Gupta, Yoram Kluger, Ferdinando Agresta, Salomone D. Saverio, Gregorio Tugnoli, Elio JovineCarlos A. Ordonez, James F. Whelan, Gustavo P. Fraga, Carlos A. Gomes, Gerson A. Pereira Junior, Kuo Ching Yuan, Miklosh Bala, Miroslav P. Peev, Offir Ben-Ishay, Yunfeng Cui, Sanjay Marwah, Sanoop Zachariah, Imtiaz Wani, Muthukumaran Rangarajan, Boris Sakakushev, Victor Kong, Adamu Ahmed, Ashraf Abbas, Ricardo Alessandro T. Gonsaga, Gianluca Guercioni, Nereo Vettoretto, Elia Poiasina, Rafael Díaz-Nieto, Damien Massalou, Matej Skrovina, Ihor Gerych, Goran Augustin, Jakub Kenig, Vladimir Khokha, Cristian Tranà, Kenneth Yuh Y. Kok, Alain C. Mefire, Jae G. Lee, Suk Kyung Hong, Helmut Alfredo S. Lohse, Wagih Ghnnam, Alfredo Verni, Varut Lohsiriwat, Boonying Siribumrungwong, Tamer El Zalabany, Alberto Tavares, Gianluca Baiocchi, Koray Das, Julien Jarry, Maurice Zida, Norio Sato, Kiyoshi Murata, Tomohisa Shoko, Takayuki Irahara, Ahmed O. Hamedelneel, Noel Naidoo, Abdul Rashid K. Adesunkanmi, Yoshiro Kobe, Wataru Ishii, Kazuyuki Oka, Yoshimitsu Izawa, Hytham Hamid, Iqbal Khan, AK K. Attri, Rajeev Sharma, Juan Sanjuan, Marisol Badiel, Rita Barnabé

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs).1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients.827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses.The overall mortality rate was 10.5% (199/1898).According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).

Original languageEnglish
Article number37
JournalWorld Journal of Emergency Surgery
Volume9
Issue number1
DOIs
Publication statusPublished - 2014 May 14

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Intraabdominal Infections
Peritonitis
Observational Studies
Community-Acquired Infections
Mortality
Cross Infection
Immunosuppression
Abscess
Multicenter Studies
Drainage
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Emergency Medicine

Cite this

Sartelli, M., Catena, F., Ansaloni, L., Coccolini, F., Corbella, D., Moore, E. E., ... Barnabé, R. (2014). Complicated intra-abdominal infections worldwide: The definitive data of the CIAOW Study. World Journal of Emergency Surgery, 9(1), [37]. https://doi.org/10.1186/1749-7922-9-37
Sartelli, Massimo ; Catena, Fausto ; Ansaloni, Luca ; Coccolini, Federico ; Corbella, Davide ; Moore, Ernest E. ; Malangoni, Mark ; Velmahos, George ; Coimbra, Raul ; Koike, Kaoru ; Leppaniemi, Ari ; Biffl, Walter ; Balogh, Zsolt ; Bendinelli, Cino ; Gupta, Sanjay ; Kluger, Yoram ; Agresta, Ferdinando ; Saverio, Salomone D. ; Tugnoli, Gregorio ; Jovine, Elio ; Ordonez, Carlos A. ; Whelan, James F. ; Fraga, Gustavo P. ; Gomes, Carlos A. ; Pereira Junior, Gerson A. ; Yuan, Kuo Ching ; Bala, Miklosh ; Peev, Miroslav P. ; Ben-Ishay, Offir ; Cui, Yunfeng ; Marwah, Sanjay ; Zachariah, Sanoop ; Wani, Imtiaz ; Rangarajan, Muthukumaran ; Sakakushev, Boris ; Kong, Victor ; Ahmed, Adamu ; Abbas, Ashraf ; Gonsaga, Ricardo Alessandro T. ; Guercioni, Gianluca ; Vettoretto, Nereo ; Poiasina, Elia ; Díaz-Nieto, Rafael ; Massalou, Damien ; Skrovina, Matej ; Gerych, Ihor ; Augustin, Goran ; Kenig, Jakub ; Khokha, Vladimir ; Tranà, Cristian ; Kok, Kenneth Yuh Y. ; Mefire, Alain C. ; Lee, Jae G. ; Hong, Suk Kyung ; Lohse, Helmut Alfredo S. ; Ghnnam, Wagih ; Verni, Alfredo ; Lohsiriwat, Varut ; Siribumrungwong, Boonying ; El Zalabany, Tamer ; Tavares, Alberto ; Baiocchi, Gianluca ; Das, Koray ; Jarry, Julien ; Zida, Maurice ; Sato, Norio ; Murata, Kiyoshi ; Shoko, Tomohisa ; Irahara, Takayuki ; Hamedelneel, Ahmed O. ; Naidoo, Noel ; Adesunkanmi, Abdul Rashid K. ; Kobe, Yoshiro ; Ishii, Wataru ; Oka, Kazuyuki ; Izawa, Yoshimitsu ; Hamid, Hytham ; Khan, Iqbal ; Attri, AK K. ; Sharma, Rajeev ; Sanjuan, Juan ; Badiel, Marisol ; Barnabé, Rita. / Complicated intra-abdominal infections worldwide : The definitive data of the CIAOW Study. In: World Journal of Emergency Surgery. 2014 ; Vol. 9, No. 1.
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abstract = "The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs).1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41{\%}) were women and 1,121 (59{\%}) were men. Among these patients, 1,645 (86.7{\%}) were affected by community-acquired IAIs while the remaining 253 (13.3{\%}) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7{\%}) of the enrolled patients.827 patients (43.6{\%}) were affected by generalized peritonitis while 1071 (56.4{\%}) suffered from localized peritonitis or abscesses.The overall mortality rate was 10.5{\%} (199/1898).According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95{\%}CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95{\%}CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95{\%}CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95{\%}CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95{\%}CI = 2.1-6.7; p < 0.0001).",
author = "Massimo Sartelli and Fausto Catena and Luca Ansaloni and Federico Coccolini and Davide Corbella and Moore, {Ernest E.} and Mark Malangoni and George Velmahos and Raul Coimbra and Kaoru Koike and Ari Leppaniemi and Walter Biffl and Zsolt Balogh and Cino Bendinelli and Sanjay Gupta and Yoram Kluger and Ferdinando Agresta and Saverio, {Salomone D.} and Gregorio Tugnoli and Elio Jovine and Ordonez, {Carlos A.} and Whelan, {James F.} and Fraga, {Gustavo P.} and Gomes, {Carlos A.} and {Pereira Junior}, {Gerson A.} and Yuan, {Kuo Ching} and Miklosh Bala and Peev, {Miroslav P.} and Offir Ben-Ishay and Yunfeng Cui and Sanjay Marwah and Sanoop Zachariah and Imtiaz Wani and Muthukumaran Rangarajan and Boris Sakakushev and Victor Kong and Adamu Ahmed and Ashraf Abbas and Gonsaga, {Ricardo Alessandro T.} and Gianluca Guercioni and Nereo Vettoretto and Elia Poiasina and Rafael D{\'i}az-Nieto and Damien Massalou and Matej Skrovina and Ihor Gerych and Goran Augustin and Jakub Kenig and Vladimir Khokha and Cristian Tran{\`a} and Kok, {Kenneth Yuh Y.} and Mefire, {Alain C.} and Lee, {Jae G.} and Hong, {Suk Kyung} and Lohse, {Helmut Alfredo S.} and Wagih Ghnnam and Alfredo Verni and Varut Lohsiriwat and Boonying Siribumrungwong and {El Zalabany}, Tamer and Alberto Tavares and Gianluca Baiocchi and Koray Das and Julien Jarry and Maurice Zida and Norio Sato and Kiyoshi Murata and Tomohisa Shoko and Takayuki Irahara and Hamedelneel, {Ahmed O.} and Noel Naidoo and Adesunkanmi, {Abdul Rashid K.} and Yoshiro Kobe and Wataru Ishii and Kazuyuki Oka and Yoshimitsu Izawa and Hytham Hamid and Iqbal Khan and Attri, {AK K.} and Rajeev Sharma and Juan Sanjuan and Marisol Badiel and Rita Barnab{\'e}",
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Sartelli, M, Catena, F, Ansaloni, L, Coccolini, F, Corbella, D, Moore, EE, Malangoni, M, Velmahos, G, Coimbra, R, Koike, K, Leppaniemi, A, Biffl, W, Balogh, Z, Bendinelli, C, Gupta, S, Kluger, Y, Agresta, F, Saverio, SD, Tugnoli, G, Jovine, E, Ordonez, CA, Whelan, JF, Fraga, GP, Gomes, CA, Pereira Junior, GA, Yuan, KC, Bala, M, Peev, MP, Ben-Ishay, O, Cui, Y, Marwah, S, Zachariah, S, Wani, I, Rangarajan, M, Sakakushev, B, Kong, V, Ahmed, A, Abbas, A, Gonsaga, RAT, Guercioni, G, Vettoretto, N, Poiasina, E, Díaz-Nieto, R, Massalou, D, Skrovina, M, Gerych, I, Augustin, G, Kenig, J, Khokha, V, Tranà, C, Kok, KYY, Mefire, AC, Lee, JG, Hong, SK, Lohse, HAS, Ghnnam, W, Verni, A, Lohsiriwat, V, Siribumrungwong, B, El Zalabany, T, Tavares, A, Baiocchi, G, Das, K, Jarry, J, Zida, M, Sato, N, Murata, K, Shoko, T, Irahara, T, Hamedelneel, AO, Naidoo, N, Adesunkanmi, ARK, Kobe, Y, Ishii, W, Oka, K, Izawa, Y, Hamid, H, Khan, I, Attri, AKK, Sharma, R, Sanjuan, J, Badiel, M & Barnabé, R 2014, 'Complicated intra-abdominal infections worldwide: The definitive data of the CIAOW Study', World Journal of Emergency Surgery, vol. 9, no. 1, 37. https://doi.org/10.1186/1749-7922-9-37

Complicated intra-abdominal infections worldwide : The definitive data of the CIAOW Study. / Sartelli, Massimo; Catena, Fausto; Ansaloni, Luca; Coccolini, Federico; Corbella, Davide; Moore, Ernest E.; Malangoni, Mark; Velmahos, George; Coimbra, Raul; Koike, Kaoru; Leppaniemi, Ari; Biffl, Walter; Balogh, Zsolt; Bendinelli, Cino; Gupta, Sanjay; Kluger, Yoram; Agresta, Ferdinando; Saverio, Salomone D.; Tugnoli, Gregorio; Jovine, Elio; Ordonez, Carlos A.; Whelan, James F.; Fraga, Gustavo P.; Gomes, Carlos A.; Pereira Junior, Gerson A.; Yuan, Kuo Ching; Bala, Miklosh; Peev, Miroslav P.; Ben-Ishay, Offir; Cui, Yunfeng; Marwah, Sanjay; Zachariah, Sanoop; Wani, Imtiaz; Rangarajan, Muthukumaran; Sakakushev, Boris; Kong, Victor; Ahmed, Adamu; Abbas, Ashraf; Gonsaga, Ricardo Alessandro T.; Guercioni, Gianluca; Vettoretto, Nereo; Poiasina, Elia; Díaz-Nieto, Rafael; Massalou, Damien; Skrovina, Matej; Gerych, Ihor; Augustin, Goran; Kenig, Jakub; Khokha, Vladimir; Tranà, Cristian; Kok, Kenneth Yuh Y.; Mefire, Alain C.; Lee, Jae G.; Hong, Suk Kyung; Lohse, Helmut Alfredo S.; Ghnnam, Wagih; Verni, Alfredo; Lohsiriwat, Varut; Siribumrungwong, Boonying; El Zalabany, Tamer; Tavares, Alberto; Baiocchi, Gianluca; Das, Koray; Jarry, Julien; Zida, Maurice; Sato, Norio; Murata, Kiyoshi; Shoko, Tomohisa; Irahara, Takayuki; Hamedelneel, Ahmed O.; Naidoo, Noel; Adesunkanmi, Abdul Rashid K.; Kobe, Yoshiro; Ishii, Wataru; Oka, Kazuyuki; Izawa, Yoshimitsu; Hamid, Hytham; Khan, Iqbal; Attri, AK K.; Sharma, Rajeev; Sanjuan, Juan; Badiel, Marisol; Barnabé, Rita.

In: World Journal of Emergency Surgery, Vol. 9, No. 1, 37, 14.05.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Complicated intra-abdominal infections worldwide

T2 - The definitive data of the CIAOW Study

AU - Sartelli, Massimo

AU - Catena, Fausto

AU - Ansaloni, Luca

AU - Coccolini, Federico

AU - Corbella, Davide

AU - Moore, Ernest E.

AU - Malangoni, Mark

AU - Velmahos, George

AU - Coimbra, Raul

AU - Koike, Kaoru

AU - Leppaniemi, Ari

AU - Biffl, Walter

AU - Balogh, Zsolt

AU - Bendinelli, Cino

AU - Gupta, Sanjay

AU - Kluger, Yoram

AU - Agresta, Ferdinando

AU - Saverio, Salomone D.

AU - Tugnoli, Gregorio

AU - Jovine, Elio

AU - Ordonez, Carlos A.

AU - Whelan, James F.

AU - Fraga, Gustavo P.

AU - Gomes, Carlos A.

AU - Pereira Junior, Gerson A.

AU - Yuan, Kuo Ching

AU - Bala, Miklosh

AU - Peev, Miroslav P.

AU - Ben-Ishay, Offir

AU - Cui, Yunfeng

AU - Marwah, Sanjay

AU - Zachariah, Sanoop

AU - Wani, Imtiaz

AU - Rangarajan, Muthukumaran

AU - Sakakushev, Boris

AU - Kong, Victor

AU - Ahmed, Adamu

AU - Abbas, Ashraf

AU - Gonsaga, Ricardo Alessandro T.

AU - Guercioni, Gianluca

AU - Vettoretto, Nereo

AU - Poiasina, Elia

AU - Díaz-Nieto, Rafael

AU - Massalou, Damien

AU - Skrovina, Matej

AU - Gerych, Ihor

AU - Augustin, Goran

AU - Kenig, Jakub

AU - Khokha, Vladimir

AU - Tranà, Cristian

AU - Kok, Kenneth Yuh Y.

AU - Mefire, Alain C.

AU - Lee, Jae G.

AU - Hong, Suk Kyung

AU - Lohse, Helmut Alfredo S.

AU - Ghnnam, Wagih

AU - Verni, Alfredo

AU - Lohsiriwat, Varut

AU - Siribumrungwong, Boonying

AU - El Zalabany, Tamer

AU - Tavares, Alberto

AU - Baiocchi, Gianluca

AU - Das, Koray

AU - Jarry, Julien

AU - Zida, Maurice

AU - Sato, Norio

AU - Murata, Kiyoshi

AU - Shoko, Tomohisa

AU - Irahara, Takayuki

AU - Hamedelneel, Ahmed O.

AU - Naidoo, Noel

AU - Adesunkanmi, Abdul Rashid K.

AU - Kobe, Yoshiro

AU - Ishii, Wataru

AU - Oka, Kazuyuki

AU - Izawa, Yoshimitsu

AU - Hamid, Hytham

AU - Khan, Iqbal

AU - Attri, AK K.

AU - Sharma, Rajeev

AU - Sanjuan, Juan

AU - Badiel, Marisol

AU - Barnabé, Rita

PY - 2014/5/14

Y1 - 2014/5/14

N2 - The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs).1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients.827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses.The overall mortality rate was 10.5% (199/1898).According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).

AB - The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs).1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients.827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses.The overall mortality rate was 10.5% (199/1898).According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).

UR - http://www.scopus.com/inward/record.url?scp=84901696806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901696806&partnerID=8YFLogxK

U2 - 10.1186/1749-7922-9-37

DO - 10.1186/1749-7922-9-37

M3 - Article

AN - SCOPUS:84901696806

VL - 9

JO - World Journal of Emergency Surgery

JF - World Journal of Emergency Surgery

SN - 1749-7922

IS - 1

M1 - 37

ER -