Complications requiring hospital admission and causes of in-hospital death over time in alcoholic and nonalcoholic cirrhosis patients

Hee Yeon Kim, Chang Wook Kim, Jong Young Choi, Chang Don Lee, Sae Hwan Lee, Moonyoung Kim, Byoung Kuk Jang, Hyun Young Woo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Aims: Data on the epidemiology of alcoholic cirrhosis, especially in Asian countries, are limited. We compared the temporal evolution of patterns of alcoholic and nonalcoholic cirrhosis over the last decade. Methods: We retrospectively examined the inpatient datasets of five referral centers during 2002 and 2011. The study included patients who were admitted due to specific complications of liver cirrhosis. We compared the causes of hospital admissions and in-hospital deaths between patients with alcoholic and nonalcoholic cirrhosis. Results: Among the included 2,799 hospitalizations (2,165 patients), 1,496 (1,143 patients) were from 2002, and 1,303 (1,022 patients) were from 2011. Over time, there was a reduction in the rate of hepatic encephalopathy (HE) as a cause of hospitalization and an increase in the rate of hepatocellular carcinoma. Deaths that were attributable to HE or spontaneous bacterial peritonitis (SBP) significantly decreased, whereas those due to hepatorenal syndrome (HRS) significantly increased over time in patients with alcoholic cirrhosis. However, in patients with nonalcoholic cirrhosis, hepatic failure and HRS remained the principal causes of in-hospital death during both time periods. Conclusions: The major causes of in-hospital deaths have evolved from acute cirrhotic complications, including HE or SBP to HRS in alcoholic cirrhosis, whereas those have remained unchanged in nonalcoholic cirrhosis during the last decade.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalGut and liver
Volume10
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

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Alcoholic Liver Cirrhosis
Hepatorenal Syndrome
Hepatic Encephalopathy
Peritonitis
Hospitalization
Fibrosis
Liver Failure
Liver Cirrhosis
Inpatients
Hepatocellular Carcinoma
Epidemiology
Referral and Consultation

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kim, Hee Yeon ; Kim, Chang Wook ; Choi, Jong Young ; Lee, Chang Don ; Lee, Sae Hwan ; Kim, Moonyoung ; Jang, Byoung Kuk ; Woo, Hyun Young. / Complications requiring hospital admission and causes of in-hospital death over time in alcoholic and nonalcoholic cirrhosis patients. In: Gut and liver. 2016 ; Vol. 10, No. 1. pp. 95-100.
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Complications requiring hospital admission and causes of in-hospital death over time in alcoholic and nonalcoholic cirrhosis patients. / Kim, Hee Yeon; Kim, Chang Wook; Choi, Jong Young; Lee, Chang Don; Lee, Sae Hwan; Kim, Moonyoung; Jang, Byoung Kuk; Woo, Hyun Young.

In: Gut and liver, Vol. 10, No. 1, 01.01.2016, p. 95-100.

Research output: Contribution to journalArticle

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AU - Kim, Chang Wook

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AU - Lee, Sae Hwan

AU - Kim, Moonyoung

AU - Jang, Byoung Kuk

AU - Woo, Hyun Young

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N2 - Background/Aims: Data on the epidemiology of alcoholic cirrhosis, especially in Asian countries, are limited. We compared the temporal evolution of patterns of alcoholic and nonalcoholic cirrhosis over the last decade. Methods: We retrospectively examined the inpatient datasets of five referral centers during 2002 and 2011. The study included patients who were admitted due to specific complications of liver cirrhosis. We compared the causes of hospital admissions and in-hospital deaths between patients with alcoholic and nonalcoholic cirrhosis. Results: Among the included 2,799 hospitalizations (2,165 patients), 1,496 (1,143 patients) were from 2002, and 1,303 (1,022 patients) were from 2011. Over time, there was a reduction in the rate of hepatic encephalopathy (HE) as a cause of hospitalization and an increase in the rate of hepatocellular carcinoma. Deaths that were attributable to HE or spontaneous bacterial peritonitis (SBP) significantly decreased, whereas those due to hepatorenal syndrome (HRS) significantly increased over time in patients with alcoholic cirrhosis. However, in patients with nonalcoholic cirrhosis, hepatic failure and HRS remained the principal causes of in-hospital death during both time periods. Conclusions: The major causes of in-hospital deaths have evolved from acute cirrhotic complications, including HE or SBP to HRS in alcoholic cirrhosis, whereas those have remained unchanged in nonalcoholic cirrhosis during the last decade.

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