Complications, treatments, and visual prognosis of choroidal osteomas

Hyo Jin Seong, Yong Joon Kim, Eun Young Choi, Junwon Lee, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Christopher Seungkyu Lee

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Purpose: This study aims to report complications, treatments, and visual prognosis of choroidal osteoma. Methods: We retrospectively reviewed electronic medical records and multimodal images of 41 patients with choroidal osteoma. Results: Visually significant complications included choroidal neovascularization (CNV) in 21 (47.7%) eyes and subretinal fluid (SRF) without CNV in 14 (31.8%) eyes. The most common treatment was intravitreal anti-vascular endothelial growth factor (VEGF) injection: 13 (61.9%) eyes with CNV received an average of 6.3 injections, and 6 (42.9%) eyes with SRF but without CNV received 1.8 injections. As the first-line treatment, intravitreal anti-VEGF injection induced complete or partial remission in 93.4% of eyes with CNV and 57.1% of eyes with SRF. The probability of legally low vision estimated at 3 and at 5 years was 29.1% and 34.2%, respectively. The presence of CNV and outer retinal tubulation (ORT) was independent risk factors for vision loss (adjusted odds ratio, 8.08 and 6.94, respectively). Conclusions: The development of CNV and ORT was strong risk factors for visual impairment. Due to the frequent recurrence of complications and poor visual prognosis, regular check-ups and appropriate treatment choices are warranted.

Original languageEnglish
Pages (from-to)1713-1721
Number of pages9
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number5
Publication statusPublished - 2022 May

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) under 2019R1A2C2002393 (C. S. L.). The funding organization had no role in the design or conduct of this research.

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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