Composite neuroendocrine and adenocarcinoma of the common bile duct associated with Clonorchis sinensis

A case report

SeHoon Kim, Nyun Park Young Nyun Park, Sup Yoon Dong Sup Yoon, Joon Lee Se Joon Lee, Sik Yu Jeong Sik Yu, Woong Noh Tae Woong Noh

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The biliary tract has neuroendocrine cells of endoderm origin similar to the gastrointestinal tract, however neuroendocrine tumors of the biliary tract are rare. We report a composite glandular-endocrine cell carcinoma of the common bile duct in a 64-year-old Korean man which was associated with Clonorchis sinensis. The patient complained of right upper quadrant abdominal pain. Several parasites of Clonorchis sinensis were removed during the percutaneous transbiliary drainage. Endoscopic retrograde cholangiopancreatography revealed a polypoid mass (3x3cm) with central ulceration in the common bile duct. Pancreaticoduodenectomy was performed. Microscopic examination of the tumor revealed a composite small cell neuroendocrine carcinoma and adenocarcinoma. The small cell carcinoma component showed positive reaction to chromogranin A and neuron-specific enolase and it was located mainly in the deeper portion of the mass. The well-differentiated adenocarcinoma component showed a positive reaction to carcinoembryonic antigen and it was situated in the superficial portion of the mass. Exclusively, the small cell component metastasized to the lymph node. It is suggested that this tumor could arise from a multipotential stem cell and showed neuroendocrine and glandular differentiation and that Clonorchis sinensis could be a predisposing factor, as in cholangiocarcinoma.

Original languageEnglish
Pages (from-to)942-944
Number of pages3
JournalHepato-Gastroenterology
Volume47
Issue number34
Publication statusPublished - 2000 Jan 1

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Clonorchis sinensis
Common Bile Duct
Adenocarcinoma
Small Cell Carcinoma
Biliary Tract
Cellular Structures
Neuroendocrine Carcinoma
Chromogranin A
Neuroendocrine Cells
Endoderm
Pancreaticoduodenectomy
Endocrine Cells
Neuroendocrine Tumors
Cholangiocarcinoma
Phosphopyruvate Hydratase
Endoscopic Retrograde Cholangiopancreatography
Carcinoembryonic Antigen
Patient Rights
Causality
Abdominal Pain

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kim, S., Young Nyun Park, N. P., Dong Sup Yoon, S. Y., Se Joon Lee, J. L., Jeong Sik Yu, S. Y., & Tae Woong Noh, W. N. (2000). Composite neuroendocrine and adenocarcinoma of the common bile duct associated with Clonorchis sinensis: A case report. Hepato-Gastroenterology, 47(34), 942-944.
Kim, SeHoon ; Young Nyun Park, Nyun Park ; Dong Sup Yoon, Sup Yoon ; Se Joon Lee, Joon Lee ; Jeong Sik Yu, Sik Yu ; Tae Woong Noh, Woong Noh. / Composite neuroendocrine and adenocarcinoma of the common bile duct associated with Clonorchis sinensis : A case report. In: Hepato-Gastroenterology. 2000 ; Vol. 47, No. 34. pp. 942-944.
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Kim, S, Young Nyun Park, NP, Dong Sup Yoon, SY, Se Joon Lee, JL, Jeong Sik Yu, SY & Tae Woong Noh, WN 2000, 'Composite neuroendocrine and adenocarcinoma of the common bile duct associated with Clonorchis sinensis: A case report', Hepato-Gastroenterology, vol. 47, no. 34, pp. 942-944.

Composite neuroendocrine and adenocarcinoma of the common bile duct associated with Clonorchis sinensis : A case report. / Kim, SeHoon; Young Nyun Park, Nyun Park; Dong Sup Yoon, Sup Yoon; Se Joon Lee, Joon Lee; Jeong Sik Yu, Sik Yu; Tae Woong Noh, Woong Noh.

In: Hepato-Gastroenterology, Vol. 47, No. 34, 01.01.2000, p. 942-944.

Research output: Contribution to journalArticle

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AB - The biliary tract has neuroendocrine cells of endoderm origin similar to the gastrointestinal tract, however neuroendocrine tumors of the biliary tract are rare. We report a composite glandular-endocrine cell carcinoma of the common bile duct in a 64-year-old Korean man which was associated with Clonorchis sinensis. The patient complained of right upper quadrant abdominal pain. Several parasites of Clonorchis sinensis were removed during the percutaneous transbiliary drainage. Endoscopic retrograde cholangiopancreatography revealed a polypoid mass (3x3cm) with central ulceration in the common bile duct. Pancreaticoduodenectomy was performed. Microscopic examination of the tumor revealed a composite small cell neuroendocrine carcinoma and adenocarcinoma. The small cell carcinoma component showed positive reaction to chromogranin A and neuron-specific enolase and it was located mainly in the deeper portion of the mass. The well-differentiated adenocarcinoma component showed a positive reaction to carcinoembryonic antigen and it was situated in the superficial portion of the mass. Exclusively, the small cell component metastasized to the lymph node. It is suggested that this tumor could arise from a multipotential stem cell and showed neuroendocrine and glandular differentiation and that Clonorchis sinensis could be a predisposing factor, as in cholangiocarcinoma.

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Kim S, Young Nyun Park NP, Dong Sup Yoon SY, Se Joon Lee JL, Jeong Sik Yu SY, Tae Woong Noh WN. Composite neuroendocrine and adenocarcinoma of the common bile duct associated with Clonorchis sinensis: A case report. Hepato-Gastroenterology. 2000 Jan 1;47(34):942-944.