Comprehensive analysis of clinicopathologic factors predictive of an unfavorable prognosis in patients with acinic cell carcinoma of the parotid gland

Young Min Park, Sun Och Yoon, Joo Hyun Kim, Min Seok Kang, Da Hee Kim, Yoon Woo Koh, Se Heon Kim, Jae Yol Lim, Eun Chang Choi

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives. In subset of patients, acinic cell carcinoma (AcCC) exhibits aggressive features such as recurrence, distant me-tastasis, and mortality. This study aimed to investigate clinicopathologic factors influencing patients’ prognosis and to identify adverse features predictive of an unfavorable prognosis. Methods. Between January 2000 and December 2016, 59 patients with AcCC were enrolled in this study. Results. The patients’ 5-year overall survival rate was 93.3%, and their 5-year recurrence-free survival rate was 80.5%. During the study period, recurrence occurred in 10 patients. The mean time to recurrence after surgery was 26 months (range, 5–60 months). During the study period, three patients died from the disease. Univariate analysis showed that sex, surgical extent, extranodal extension, T classification, and TNM stage were significantly associated with disease recurrence. Multivariate analysis showed that, among the clinicopathologic factors included in the analy-sis, only TNM stage displayed a statistically significant correlation with disease recurrence. Conclusion. Surgical treatment alone yielded good results for AcCC, and additional treatment did not affect the recurrence-free survival rate or the overall survival rate, even when the resection margin was less than 1 mm. Other pathologic factors did not show prognostic significance for disease recurrence or death.

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalClinical and Experimental Otorhinolaryngology
Volume14
Issue number1
DOIs
Publication statusPublished - 2021 Feb

Bibliographical note

Publisher Copyright:
© 2021 by Korean Society of Otorhinolaryngology-Head and Neck Surgery.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

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