TY - JOUR
T1 - Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer
AU - Lee, Ji Hyun
AU - You, Sungyong
AU - Hyeon, Do Young
AU - Kang, Byeongsoo
AU - Kim, Hyerim
AU - Park, Kyoung Mii
AU - Han, Byungwoo
AU - Hwang, Daehee
AU - Kim, Sunghoon
N1 - Publisher Copyright:
© The Author(s) 2015. Published by Oxford University Press.
PY - 2015
Y1 - 2015
N2 - Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in protein synthesis, recently, ARSs and ARS-interacting multifunctional proteins (AIMPs) have been shown to play important roles in disease pathogenesis through their interactions with disease-related molecules. However, there are lacks of data resources and analytical tools that can be used to examine disease associations of ARS/AIMPs. Here, we developed an Integrated Database for ARSs (IDA), a resource database including cancer genomic/proteomic and interaction data of ARS/ AIMPs. IDA includes mRNA expression, somatic mutation, copy number variation and phosphorylation data of ARS/AIMPs and their interacting proteins in various cancers. IDA further includes an array of analytical tools for exploration of disease association of ARS/AIMPs, identification of disease-associated ARS/AIMP interactors and reconstruction of ARS-dependent disease-perturbed network models. Therefore, IDA provides both comprehensive data resources and analytical tools for understanding potential roles of ARS/AIMPs in cancers.
AB - Mammalian cells have cytoplasmic and mitochondrial aminoacyl-tRNA synthetases (ARSs) that catalyze aminoacylation of tRNAs during protein synthesis. Despite their housekeeping functions in protein synthesis, recently, ARSs and ARS-interacting multifunctional proteins (AIMPs) have been shown to play important roles in disease pathogenesis through their interactions with disease-related molecules. However, there are lacks of data resources and analytical tools that can be used to examine disease associations of ARS/AIMPs. Here, we developed an Integrated Database for ARSs (IDA), a resource database including cancer genomic/proteomic and interaction data of ARS/ AIMPs. IDA includes mRNA expression, somatic mutation, copy number variation and phosphorylation data of ARS/AIMPs and their interacting proteins in various cancers. IDA further includes an array of analytical tools for exploration of disease association of ARS/AIMPs, identification of disease-associated ARS/AIMP interactors and reconstruction of ARS-dependent disease-perturbed network models. Therefore, IDA provides both comprehensive data resources and analytical tools for understanding potential roles of ARS/AIMPs in cancers.
UR - http://www.scopus.com/inward/record.url?scp=84943279476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943279476&partnerID=8YFLogxK
U2 - 10.1093/database/bav022
DO - 10.1093/database/bav022
M3 - Article
C2 - 25824651
AN - SCOPUS:84943279476
VL - 2015
JO - Database : the journal of biological databases and curation
JF - Database : the journal of biological databases and curation
SN - 1758-0463
ER -