Comprehensive evaluation of coronary arteries by multidetector-row cardiac computed tomography according to the glucose level of asymptomatic individuals

Soo Lim, Sung Hee Choi, Eue Keun Choi, Sung A. Chang, Yun Hyi Ku, Eun Ju Chun, Sang Il Choi, Hak Chul Jang, Hyuk-Jae Chang

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Abstract

Background: Early detection of atherosclerosis in individuals with diabetes is important because of high cardiovascular mortality in this population. We performed multidetector-row computed tomography (MDCT) in asymptomatic individuals to investigate the status of coronary artery stenosis and plaque characteristics depending on the glucose level. Methods and results: The plaque burden (number of diseased coronary segments), severity of stenosis, plaques characteristics, and coronary artery calcium score (CACS) were assessed by MDCT in 1043 asymptomatic individuals. Anthropometric parameters and metabolic profiles were also acquired. Twenty-one percents of subjects had plaques and 5% had significant stenosis. Mean (±S.D.) CACS of study population was 17 ± 81. Subjects with impaired fasting glucose (IFG, n = 215, 21%) or diabetes (n = 112, 11%) had a greater plaque burden, more coronary stenosis (>50% of diameter stenosis) and higher CACS than normal subjects (all, p < 0.01). Noncalcified and mixed plaques were observed more in subjects with diabetes (19%) and IFG (11%) than normal (7%). After adjustment for confounding factors, higher fasting glucose was strongly associated with significant coronary stenosis and a greater plaque burden. Conclusions: More significant coronary stenosis and multivessel involvement, higher CACS, and greater plaque burden were observed in subjects with IFG or diabetes by MDCT, even they are asymptomatic. Proactive screening, irrespective of the imaging modalities used, in asymptomatic subjects with prediabetes and diabetes is helpful to identify those who have a higher cardiovascular morbidity and mortality. Further studies will guide us with respect to which imaging modality is more appropriate.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalAtherosclerosis
Volume205
Issue number1
DOIs
Publication statusPublished - 2009 Jul 1

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Multidetector Computed Tomography
Coronary Stenosis
Coronary Vessels
Glucose
Calcium
Fasting
Pathologic Constriction
Prediabetic State
Metabolome
Mortality
Population
Coronary Disease
Atherosclerosis
Morbidity

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lim, Soo ; Choi, Sung Hee ; Choi, Eue Keun ; Chang, Sung A. ; Ku, Yun Hyi ; Chun, Eun Ju ; Choi, Sang Il ; Jang, Hak Chul ; Chang, Hyuk-Jae. / Comprehensive evaluation of coronary arteries by multidetector-row cardiac computed tomography according to the glucose level of asymptomatic individuals. In: Atherosclerosis. 2009 ; Vol. 205, No. 1. pp. 156-162.
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Comprehensive evaluation of coronary arteries by multidetector-row cardiac computed tomography according to the glucose level of asymptomatic individuals. / Lim, Soo; Choi, Sung Hee; Choi, Eue Keun; Chang, Sung A.; Ku, Yun Hyi; Chun, Eun Ju; Choi, Sang Il; Jang, Hak Chul; Chang, Hyuk-Jae.

In: Atherosclerosis, Vol. 205, No. 1, 01.07.2009, p. 156-162.

Research output: Contribution to journalArticle

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AU - Choi, Sung Hee

AU - Choi, Eue Keun

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AU - Ku, Yun Hyi

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AU - Jang, Hak Chul

AU - Chang, Hyuk-Jae

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N2 - Background: Early detection of atherosclerosis in individuals with diabetes is important because of high cardiovascular mortality in this population. We performed multidetector-row computed tomography (MDCT) in asymptomatic individuals to investigate the status of coronary artery stenosis and plaque characteristics depending on the glucose level. Methods and results: The plaque burden (number of diseased coronary segments), severity of stenosis, plaques characteristics, and coronary artery calcium score (CACS) were assessed by MDCT in 1043 asymptomatic individuals. Anthropometric parameters and metabolic profiles were also acquired. Twenty-one percents of subjects had plaques and 5% had significant stenosis. Mean (±S.D.) CACS of study population was 17 ± 81. Subjects with impaired fasting glucose (IFG, n = 215, 21%) or diabetes (n = 112, 11%) had a greater plaque burden, more coronary stenosis (>50% of diameter stenosis) and higher CACS than normal subjects (all, p < 0.01). Noncalcified and mixed plaques were observed more in subjects with diabetes (19%) and IFG (11%) than normal (7%). After adjustment for confounding factors, higher fasting glucose was strongly associated with significant coronary stenosis and a greater plaque burden. Conclusions: More significant coronary stenosis and multivessel involvement, higher CACS, and greater plaque burden were observed in subjects with IFG or diabetes by MDCT, even they are asymptomatic. Proactive screening, irrespective of the imaging modalities used, in asymptomatic subjects with prediabetes and diabetes is helpful to identify those who have a higher cardiovascular morbidity and mortality. Further studies will guide us with respect to which imaging modality is more appropriate.

AB - Background: Early detection of atherosclerosis in individuals with diabetes is important because of high cardiovascular mortality in this population. We performed multidetector-row computed tomography (MDCT) in asymptomatic individuals to investigate the status of coronary artery stenosis and plaque characteristics depending on the glucose level. Methods and results: The plaque burden (number of diseased coronary segments), severity of stenosis, plaques characteristics, and coronary artery calcium score (CACS) were assessed by MDCT in 1043 asymptomatic individuals. Anthropometric parameters and metabolic profiles were also acquired. Twenty-one percents of subjects had plaques and 5% had significant stenosis. Mean (±S.D.) CACS of study population was 17 ± 81. Subjects with impaired fasting glucose (IFG, n = 215, 21%) or diabetes (n = 112, 11%) had a greater plaque burden, more coronary stenosis (>50% of diameter stenosis) and higher CACS than normal subjects (all, p < 0.01). Noncalcified and mixed plaques were observed more in subjects with diabetes (19%) and IFG (11%) than normal (7%). After adjustment for confounding factors, higher fasting glucose was strongly associated with significant coronary stenosis and a greater plaque burden. Conclusions: More significant coronary stenosis and multivessel involvement, higher CACS, and greater plaque burden were observed in subjects with IFG or diabetes by MDCT, even they are asymptomatic. Proactive screening, irrespective of the imaging modalities used, in asymptomatic subjects with prediabetes and diabetes is helpful to identify those who have a higher cardiovascular morbidity and mortality. Further studies will guide us with respect to which imaging modality is more appropriate.

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