Comprehensive immuno-molecular profiles for liposarcoma: Roles of programmed death ligand 1, microsatellite instability, and pik3ca

Hyae Min Jeon, Jae Seok Lee, Soo Hee Kim, Kum Hee Yun, Kyu Hyun Park, Min Kyung Jeon, Young Han Lee, Hong In Yoon, Jin Suck Suh, Hyuk Hur, Kyung Sik Kim, Sunghoon Kim, Seung Hyun Kim, Hyo Song Kim

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Abstract

Background: Developing personalized strategies for cancer has shown good efficacies. Methods: We assessed the molecular targets programmed death ligand 1 (PD-L1), microsatellite instability (MSI), and PIK3CA. Seventy-four patients with liposarcomas who underwent curative resection were assessed for PD-L1 expression in the tumor and tumor-infiltrating lymphocytes (TILs), mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6) by immunohistochemistry, MSI using polymerase chain reaction, and PIK3CA mutation/amplification using pyrosequencing and fluorescence in situ hybridization. Results: Seventeen (23%) cases were TIL (≥1 + expression) and associated with longer 5-year overall survival than those with TIL tumors (84.4 vs. 60.8%, p = 0.007). Six (35.3%) PD-L1 tumors were detected only in TIL cases, with none detected in tumor cells. Two well-differentiated liposarcomas showed MSI, one low and one high with concurrent loss of MLH1, MSH6, and PMS2. PIK3CA mutation was detected in 7 (9.5%) [exon 9 (n = 4) and exon 20 (n = 3)] and only 1 Q546K mutation was a PD-L1 tumor. PIK3CA copy number gain was detected in 18 (24.4%) and was associated with TIL tumors (p = 0.045). Conclusions: Our comprehensive immuno-molecular panel suggests that liposarcoma should be categorized based on the molecular genomic subtype for precision medicine.

Original languageEnglish
JournalOncology (Switzerland)
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Jeon, H. M., Lee, J. S., Kim, S. H., Yun, K. H., Park, K. H., Jeon, M. K., Lee, Y. H., Yoon, H. I., Suh, J. S., Hur, H., Kim, K. S., Kim, S., Kim, S. H., & Kim, H. S. (Accepted/In press). Comprehensive immuno-molecular profiles for liposarcoma: Roles of programmed death ligand 1, microsatellite instability, and pik3ca. Oncology (Switzerland). https://doi.org/10.1159/000509004