Computational and histological analyses for investigating mechanical interaction of thermally drawn fiber implants with brain tissue

Kanghyeon Kim, Changhoon Sung, Jungjoon Lee, Joonhee Won, Woojin Jeon, Seungbeom Seo, Kyungho Yoon, Seongjun Park

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The development of a compliant neural probe is necessary to achieve chronic implantation with minimal signal loss. Although fiber-based neural probes fabricated by the thermal drawing process have been proposed as a solution, their long-term effect on the brain has not been thoroughly investigated. Here, we examined the mechanical interaction of thermally drawn fiber implants with neural tissue through computational and histological analyses. Specifically, finite element analysis and immunohistochemistry were conducted to evaluate the biocompatibility of various fiber implants made with different base materials (steel, silica, polycarbonate, and hydrogel). Moreover, the effects of the coefficient of friction and geometric factors including aspect ratio and the shape of the cross-section on the strain were investigated with the finite element model. As a result, we observed that the fiber implants fabricated with extremely softer material such as hydrogel exhibited significantly lower strain distribution and elicited a reduced immune response. In addition, the implants with higher coefficient of friction (COF) and/or circular cross-sections showed a lower strain distribution and smaller critical volume. This work suggests the materials and design factors that need to be carefully considered to develop future fiber-based neural probes to minimize mechanical invasiveness.

Original languageEnglish
Article number394
Issue number4
Publication statusPublished - 2021 Apr

Bibliographical note

Funding Information:
Funding: This study was supported by Basic Science Research Program through National Research Foundation of Korea (NRF-2020R1C1C1007589), Korea Medical Device Development Fund grant funded by the Korean government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health and Welfare, the Ministry of Food and Drug Safety) (NTIS Number: 9991006805), and the Smart Project Program through KAIST-Khalifa Joint Research Center (KK-JRC), KAIST College of Engineering Global Initiative Convergence Research Program.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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