Computed tomographic fluoroscopy-guided needle aspiration biopsy as a second biopsy technique after indeterminate transbronchial biopsy results for pulmonary lesions: Comparison with second transbronchial biopsy

Jin Hur, Hye Jeong Lee, Min Kwang Byun, Ji Eun Nam, Jin Wook Moon, Hua Sun Kim, Young Jin Kim, Kyu Ok Choe, Byoung Wook Choi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Objective: The purpose of this study was to compare the diagnostic performance of computed tomographic (CT) fluoroscopy-guided percutaneous transthoracic needle aspiration biopsy (NAB) and transbronchial lung biopsy (TBLB) after indeterminate bronchoscopy in patients with suspected malignant pulmonary lesions. Methods: We included 77 patients who underwent CTF-NAB (n = 53) or TBLB (n = 24) as a second biopsy for pulmonary lesions because of inconclusive pathologic results on initial TBLB. Sensitivity, specificity, and diagnostic accuracy were calculated and compared between the 2 groups using the Fisher exact test. Sensitivity and diagnostic accuracy were also compared according to lesion depth (central vs peripheral), lesion location (upper vs lower), and lesion size (<2 vs 2-3 vs >3 cm). Results: There were 50 (65%) malignant and 27 (35%) benign lesions. The overall sensitivity, specificity, and accuracy for diagnosing pulmonary lesions were 84%, 100%, and 91% for NAB and 50%, 100%, and 63% for TBLB. The sensitivity and accuracy for diagnosing pulmonary lesions were significantly different between the 2 groups (P = 0.019, and P = 0.008). The sensitivity and accuracy of TBLB for diagnosing lesions was significantly different according to the lesion size (P = 0.025, and P = 0.048). Conclusion: A second biopsy using CT fluoroscopy-guided NAB is a useful diagnostic modality for exact diagnosis of pulmonary lesions in cases of inconclusive pathologic results on initial TBLB.

Original languageEnglish
Pages (from-to)290-295
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume34
Issue number2
DOIs
Publication statusPublished - 2010 Mar

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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