Computer simulations of steady concentration peritoneal dialysis

Kyoung Jin Lee, Dong Ah Shin, Hee Su Lee, Jung Chan Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Steady concentration peritoneal dialysis (SCPD), which maintains transperitoneal osmotic gradient by infusing 50% glucose solution throughout the dwell time, has been proposed as a potent treatment for peritoneal dialysis (PD) patients with fluid overload. However, SCPD has yet to be explored theoretically. Here, we investigated SCPD via computer simulations. Methods: A model was developed by adding the variables for infusing 50% glucose solution to a traditional three-pore model for continuous ambulatory PD. The simulated scenarios involved the instillation of 2-L dialysate, 1.36% or 2.27%, followed by the infusion of 50% glucose solution, varying the rate from 0 mL/h to 90 mL/h. A dwell with 3.86% dialysate was also simulated for the purpose of comparison. Four sets of patient parameters corresponding to peritoneal transport categories were used. Results: The net ultrafiltration (UF) during SCPD increased with time as well as with glucose infusion rate. The glucose absorption and sodium removal of SCPD were slightly higher than those of the conventional dwell with 3.86% dialysate under the condition of the same net UF and dwell time. SCPD resulted in the larger UF and the lower peak intraperitoneal glucose concentration when it was simulated with the higher transport properties. Conclusions: These simulations indicate that SCPD can improve UF beyond those achievable by a conventional 3.86% glucose exchange while also exhibiting a lower peak osmolarity in the dialysate as compared to a conventional 3.86% dwell. However, further studies are needed to confirm these theoretical findings.

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalPeritoneal Dialysis International
Volume40
Issue number1
DOIs
Publication statusPublished - 2020 Jan 1

Bibliographical note

Funding Information:
These simulations indicate that SCPD can improve UF beyond those achievable by a conventional 3.86% glucose exchange while also exhibiting a lower peak osmolarity in the dialysate as compared to a conventional 3.86% dwell. However, further studies are needed to confirm these theoretical findings. Fluid overload glucose concentration simulation steady concentration peritoneal dialysis (SCPD) ultrafiltration typesetter ts3 Authors’ note All authors have read and approved the content of the manuscript as submitted. Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Korean Health Technology R&D Project, Ministry of Health & Welfare (HI14C0559).

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Korean Health Technology R&D Project, Ministry of Health & Welfare (HI14C0559).

Publisher Copyright:
© The Author(s) 2020.

All Science Journal Classification (ASJC) codes

  • Nephrology

Fingerprint

Dive into the research topics of 'Computer simulations of steady concentration peritoneal dialysis'. Together they form a unique fingerprint.

Cite this