Concise synthesis and antiangiogenic activity of artemisinin-glycolipid hybrids on chorioallantoic membranes

Jérémy Ricci; Jeehyun Park; Won Yoon Chung; Kwang Kyun Park; Mankil Jung

doi:10.1016/j.bmcl.2010.08.013

Concise synthesis and antiangiogenic activity of artemisinin-glycolipid hybrids on chorioallantoic membranes

Jérémy Ricci, Jeehyun Park, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.

Original language	English
Pages (from-to)	6858-6860
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	22
DOIs	https://doi.org/10.1016/j.bmcl.2010.08.013
Publication status	Published - 2010 Nov 15

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Project (A084166), the Ministry of Health & Welfare, Republic of Korea. J.R. and J.P. received fellowships from the BK 21program of the Ministry of Education and Human Resources Development, the Republic of Korea.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2010.08.013

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abstract = "Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.",

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AU - Park, Kwang Kyun

AU - Jung, Mankil

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Concise synthesis and antiangiogenic activity of artemisinin-glycolipid hybrids on chorioallantoic membranes

Abstract

Bibliographical note

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