Concise synthesis and antiangiogenic activity of artemisinin-glycolipid hybrids on chorioallantoic membranes

Jérémy Ricci, Jeehyun Park, Won Yoon Chung, Kwang Kyun Park, Mankil Jung

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.

Original languageEnglish
Pages (from-to)6858-6860
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number22
DOIs
Publication statusPublished - 2010 Nov 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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