Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.
Bibliographical noteFunding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Project (A084166), the Ministry of Health & Welfare, Republic of Korea. J.R. and J.P. received fellowships from the BK 21program of the Ministry of Education and Human Resources Development, the Republic of Korea.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry