Concurrent Post-Transplantation Diabetes Mellitus in Renal Allograft Recipients with Immunoglobulin A Nephropathy

H. S. Jeong, J. Lee, B. J. Lim, H. J. Kwon, Y. S. Kim, B. S. Kim, K. H. Huh, S. I. Kim, M. S. Kim, H. J. Jeong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background The prevalence of post-transplantation immunoglobulin A nephropathy (PTIgAN) and diabetes mellitus (PTDM) increases with time after transplantation, and recognition and management of these conditions is becoming more important in renal allograft recipients as graft survival increases. Methods We explored the influence of concurrent PTDM on renal allograft histology and function in 111 cases with PTIgAN diagnosed from 2000 to 2010 at our institution. Results Sixteen patients (14.4%) had PTDM at the time of diagnosis of PTIgAN, which increased to 28 patients (25.2%) at the last follow-up (10.4 years after transplantation). Donor ages were younger in PTIgAN patients with concurrent PTDM. However, other clinical and demographic data were not significantly different between PTIgAN patients with and without PTDM. Histologically, Banff "mm" scores were higher and "M1" of the Oxford classification was more frequent in PTIgAN patients with concurrent PTDM than in patients without PTDM, but the difference did not reach statistical significance. Serum creatinine levels and proteinuria at the time of biopsy and overall graft survival did not vary according to the presence of PTDM both at biopsy and at the last follow-up. Conclusions Concurrent PTDM does not significantly influence graft function or outcome for 10 years after transplantation in PTIgAN patients.

Original languageEnglish
Pages (from-to)887-889
Number of pages3
JournalTransplantation Proceedings
Volume48
Issue number3
DOIs
Publication statusPublished - 2016 Apr 1

Fingerprint

IGA Glomerulonephritis
Allografts
Diabetes Mellitus
Transplantation
Kidney
Graft Survival
Biopsy
Proteinuria
Creatinine
Histology

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Jeong, H. S. ; Lee, J. ; Lim, B. J. ; Kwon, H. J. ; Kim, Y. S. ; Kim, B. S. ; Huh, K. H. ; Kim, S. I. ; Kim, M. S. ; Jeong, H. J. / Concurrent Post-Transplantation Diabetes Mellitus in Renal Allograft Recipients with Immunoglobulin A Nephropathy. In: Transplantation Proceedings. 2016 ; Vol. 48, No. 3. pp. 887-889.
@article{73acc57dc0c84c15a37b0ed6cc61965f,
title = "Concurrent Post-Transplantation Diabetes Mellitus in Renal Allograft Recipients with Immunoglobulin A Nephropathy",
abstract = "Background The prevalence of post-transplantation immunoglobulin A nephropathy (PTIgAN) and diabetes mellitus (PTDM) increases with time after transplantation, and recognition and management of these conditions is becoming more important in renal allograft recipients as graft survival increases. Methods We explored the influence of concurrent PTDM on renal allograft histology and function in 111 cases with PTIgAN diagnosed from 2000 to 2010 at our institution. Results Sixteen patients (14.4{\%}) had PTDM at the time of diagnosis of PTIgAN, which increased to 28 patients (25.2{\%}) at the last follow-up (10.4 years after transplantation). Donor ages were younger in PTIgAN patients with concurrent PTDM. However, other clinical and demographic data were not significantly different between PTIgAN patients with and without PTDM. Histologically, Banff {"}mm{"} scores were higher and {"}M1{"} of the Oxford classification was more frequent in PTIgAN patients with concurrent PTDM than in patients without PTDM, but the difference did not reach statistical significance. Serum creatinine levels and proteinuria at the time of biopsy and overall graft survival did not vary according to the presence of PTDM both at biopsy and at the last follow-up. Conclusions Concurrent PTDM does not significantly influence graft function or outcome for 10 years after transplantation in PTIgAN patients.",
author = "Jeong, {H. S.} and J. Lee and Lim, {B. J.} and Kwon, {H. J.} and Kim, {Y. S.} and Kim, {B. S.} and Huh, {K. H.} and Kim, {S. I.} and Kim, {M. S.} and Jeong, {H. J.}",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.transproceed.2015.11.032",
language = "English",
volume = "48",
pages = "887--889",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "3",

}

Concurrent Post-Transplantation Diabetes Mellitus in Renal Allograft Recipients with Immunoglobulin A Nephropathy. / Jeong, H. S.; Lee, J.; Lim, B. J.; Kwon, H. J.; Kim, Y. S.; Kim, B. S.; Huh, K. H.; Kim, S. I.; Kim, M. S.; Jeong, H. J.

In: Transplantation Proceedings, Vol. 48, No. 3, 01.04.2016, p. 887-889.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Concurrent Post-Transplantation Diabetes Mellitus in Renal Allograft Recipients with Immunoglobulin A Nephropathy

AU - Jeong, H. S.

AU - Lee, J.

AU - Lim, B. J.

AU - Kwon, H. J.

AU - Kim, Y. S.

AU - Kim, B. S.

AU - Huh, K. H.

AU - Kim, S. I.

AU - Kim, M. S.

AU - Jeong, H. J.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background The prevalence of post-transplantation immunoglobulin A nephropathy (PTIgAN) and diabetes mellitus (PTDM) increases with time after transplantation, and recognition and management of these conditions is becoming more important in renal allograft recipients as graft survival increases. Methods We explored the influence of concurrent PTDM on renal allograft histology and function in 111 cases with PTIgAN diagnosed from 2000 to 2010 at our institution. Results Sixteen patients (14.4%) had PTDM at the time of diagnosis of PTIgAN, which increased to 28 patients (25.2%) at the last follow-up (10.4 years after transplantation). Donor ages were younger in PTIgAN patients with concurrent PTDM. However, other clinical and demographic data were not significantly different between PTIgAN patients with and without PTDM. Histologically, Banff "mm" scores were higher and "M1" of the Oxford classification was more frequent in PTIgAN patients with concurrent PTDM than in patients without PTDM, but the difference did not reach statistical significance. Serum creatinine levels and proteinuria at the time of biopsy and overall graft survival did not vary according to the presence of PTDM both at biopsy and at the last follow-up. Conclusions Concurrent PTDM does not significantly influence graft function or outcome for 10 years after transplantation in PTIgAN patients.

AB - Background The prevalence of post-transplantation immunoglobulin A nephropathy (PTIgAN) and diabetes mellitus (PTDM) increases with time after transplantation, and recognition and management of these conditions is becoming more important in renal allograft recipients as graft survival increases. Methods We explored the influence of concurrent PTDM on renal allograft histology and function in 111 cases with PTIgAN diagnosed from 2000 to 2010 at our institution. Results Sixteen patients (14.4%) had PTDM at the time of diagnosis of PTIgAN, which increased to 28 patients (25.2%) at the last follow-up (10.4 years after transplantation). Donor ages were younger in PTIgAN patients with concurrent PTDM. However, other clinical and demographic data were not significantly different between PTIgAN patients with and without PTDM. Histologically, Banff "mm" scores were higher and "M1" of the Oxford classification was more frequent in PTIgAN patients with concurrent PTDM than in patients without PTDM, but the difference did not reach statistical significance. Serum creatinine levels and proteinuria at the time of biopsy and overall graft survival did not vary according to the presence of PTDM both at biopsy and at the last follow-up. Conclusions Concurrent PTDM does not significantly influence graft function or outcome for 10 years after transplantation in PTIgAN patients.

UR - http://www.scopus.com/inward/record.url?scp=84970028413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84970028413&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2015.11.032

DO - 10.1016/j.transproceed.2015.11.032

M3 - Article

C2 - 27234759

AN - SCOPUS:84970028413

VL - 48

SP - 887

EP - 889

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 3

ER -