Conductivity imaging of canine brain using a 3 T MREIT system: Postmortem experiments

Hyung Joong Kim, Byung Il Lee, Young Cho, Young Tae Kim, Byeong Teck Kang, Hee Myung Park, Soo Yeol Lee, Jin Keun Seo, Eung Je Woo

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Magnetic resonance electrical impedance tomography (MREIT) has the potential to provide conductivity images with high spatial resolution and accuracy. Recent studies using various conductivity phantoms showed that the spatial resolution could be similar to that of conventional MR images as long as enough current is injected. Before we try in vivo animal imaging studies using a small injection current of less than 5 mA, we have performed MREIT conductivity imaging of postmortem canine brains using 40 mA injection currents. The primary goals were to produce high-resolution conductivity images of white and gray matter in situ and to accumulate experimental techniques to undertake in vivo animal imaging studies in the near future. Reconstructed conductivity images of two canine brains with a pixel size of 1.4 × 1.4 mm2 showed a clear conductivity contrast between gray and white matter. Considering the anisotropic conductivity of white matter, we interpreted reconstructed conductivity images as equivalent isotropic conductivity images. Estimated conductivity ratios of white to gray matter were between 1.13 and 1.20 depending on the choice of a region of interest in reconstructed images. A higher conductivity value of white matter compared with that of gray matter stems from the fact that the reconstructed equivalent isotropic conductivity value of white matter reflects a high conductivity of white matter in the direction parallel to its fibers. We expect that this kind of postmortem animal imaging can provide conductivity information on tissues in situ to be utilized in numerous modeling studies.

Original languageEnglish
Pages (from-to)1341-1353
Number of pages13
JournalPhysiological measurement
Volume28
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1

Fingerprint

Acoustic impedance
Magnetic resonance
Electric Impedance
Neuroimaging
Tomography
Canidae
Brain
Magnetic Resonance Spectroscopy
Imaging techniques
Animals
Experiments
Injections
Pixels
Tissue
White Matter
Fibers
Gray Matter

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Physiology
  • Biomedical Engineering
  • Physiology (medical)

Cite this

Kim, H. J., Lee, B. I., Cho, Y., Kim, Y. T., Kang, B. T., Park, H. M., ... Woo, E. J. (2007). Conductivity imaging of canine brain using a 3 T MREIT system: Postmortem experiments. Physiological measurement, 28(11), 1341-1353. https://doi.org/10.1088/0967-3334/28/11/002
Kim, Hyung Joong ; Lee, Byung Il ; Cho, Young ; Kim, Young Tae ; Kang, Byeong Teck ; Park, Hee Myung ; Lee, Soo Yeol ; Seo, Jin Keun ; Woo, Eung Je. / Conductivity imaging of canine brain using a 3 T MREIT system : Postmortem experiments. In: Physiological measurement. 2007 ; Vol. 28, No. 11. pp. 1341-1353.
@article{afe60d7a2398409fb16bade35a84fe19,
title = "Conductivity imaging of canine brain using a 3 T MREIT system: Postmortem experiments",
abstract = "Magnetic resonance electrical impedance tomography (MREIT) has the potential to provide conductivity images with high spatial resolution and accuracy. Recent studies using various conductivity phantoms showed that the spatial resolution could be similar to that of conventional MR images as long as enough current is injected. Before we try in vivo animal imaging studies using a small injection current of less than 5 mA, we have performed MREIT conductivity imaging of postmortem canine brains using 40 mA injection currents. The primary goals were to produce high-resolution conductivity images of white and gray matter in situ and to accumulate experimental techniques to undertake in vivo animal imaging studies in the near future. Reconstructed conductivity images of two canine brains with a pixel size of 1.4 × 1.4 mm2 showed a clear conductivity contrast between gray and white matter. Considering the anisotropic conductivity of white matter, we interpreted reconstructed conductivity images as equivalent isotropic conductivity images. Estimated conductivity ratios of white to gray matter were between 1.13 and 1.20 depending on the choice of a region of interest in reconstructed images. A higher conductivity value of white matter compared with that of gray matter stems from the fact that the reconstructed equivalent isotropic conductivity value of white matter reflects a high conductivity of white matter in the direction parallel to its fibers. We expect that this kind of postmortem animal imaging can provide conductivity information on tissues in situ to be utilized in numerous modeling studies.",
author = "Kim, {Hyung Joong} and Lee, {Byung Il} and Young Cho and Kim, {Young Tae} and Kang, {Byeong Teck} and Park, {Hee Myung} and Lee, {Soo Yeol} and Seo, {Jin Keun} and Woo, {Eung Je}",
year = "2007",
month = "11",
day = "1",
doi = "10.1088/0967-3334/28/11/002",
language = "English",
volume = "28",
pages = "1341--1353",
journal = "Physiological Measurement",
issn = "0967-3334",
publisher = "IOP Publishing Ltd.",
number = "11",

}

Kim, HJ, Lee, BI, Cho, Y, Kim, YT, Kang, BT, Park, HM, Lee, SY, Seo, JK & Woo, EJ 2007, 'Conductivity imaging of canine brain using a 3 T MREIT system: Postmortem experiments', Physiological measurement, vol. 28, no. 11, pp. 1341-1353. https://doi.org/10.1088/0967-3334/28/11/002

Conductivity imaging of canine brain using a 3 T MREIT system : Postmortem experiments. / Kim, Hyung Joong; Lee, Byung Il; Cho, Young; Kim, Young Tae; Kang, Byeong Teck; Park, Hee Myung; Lee, Soo Yeol; Seo, Jin Keun; Woo, Eung Je.

In: Physiological measurement, Vol. 28, No. 11, 01.11.2007, p. 1341-1353.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Conductivity imaging of canine brain using a 3 T MREIT system

T2 - Postmortem experiments

AU - Kim, Hyung Joong

AU - Lee, Byung Il

AU - Cho, Young

AU - Kim, Young Tae

AU - Kang, Byeong Teck

AU - Park, Hee Myung

AU - Lee, Soo Yeol

AU - Seo, Jin Keun

AU - Woo, Eung Je

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Magnetic resonance electrical impedance tomography (MREIT) has the potential to provide conductivity images with high spatial resolution and accuracy. Recent studies using various conductivity phantoms showed that the spatial resolution could be similar to that of conventional MR images as long as enough current is injected. Before we try in vivo animal imaging studies using a small injection current of less than 5 mA, we have performed MREIT conductivity imaging of postmortem canine brains using 40 mA injection currents. The primary goals were to produce high-resolution conductivity images of white and gray matter in situ and to accumulate experimental techniques to undertake in vivo animal imaging studies in the near future. Reconstructed conductivity images of two canine brains with a pixel size of 1.4 × 1.4 mm2 showed a clear conductivity contrast between gray and white matter. Considering the anisotropic conductivity of white matter, we interpreted reconstructed conductivity images as equivalent isotropic conductivity images. Estimated conductivity ratios of white to gray matter were between 1.13 and 1.20 depending on the choice of a region of interest in reconstructed images. A higher conductivity value of white matter compared with that of gray matter stems from the fact that the reconstructed equivalent isotropic conductivity value of white matter reflects a high conductivity of white matter in the direction parallel to its fibers. We expect that this kind of postmortem animal imaging can provide conductivity information on tissues in situ to be utilized in numerous modeling studies.

AB - Magnetic resonance electrical impedance tomography (MREIT) has the potential to provide conductivity images with high spatial resolution and accuracy. Recent studies using various conductivity phantoms showed that the spatial resolution could be similar to that of conventional MR images as long as enough current is injected. Before we try in vivo animal imaging studies using a small injection current of less than 5 mA, we have performed MREIT conductivity imaging of postmortem canine brains using 40 mA injection currents. The primary goals were to produce high-resolution conductivity images of white and gray matter in situ and to accumulate experimental techniques to undertake in vivo animal imaging studies in the near future. Reconstructed conductivity images of two canine brains with a pixel size of 1.4 × 1.4 mm2 showed a clear conductivity contrast between gray and white matter. Considering the anisotropic conductivity of white matter, we interpreted reconstructed conductivity images as equivalent isotropic conductivity images. Estimated conductivity ratios of white to gray matter were between 1.13 and 1.20 depending on the choice of a region of interest in reconstructed images. A higher conductivity value of white matter compared with that of gray matter stems from the fact that the reconstructed equivalent isotropic conductivity value of white matter reflects a high conductivity of white matter in the direction parallel to its fibers. We expect that this kind of postmortem animal imaging can provide conductivity information on tissues in situ to be utilized in numerous modeling studies.

UR - http://www.scopus.com/inward/record.url?scp=35848940283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35848940283&partnerID=8YFLogxK

U2 - 10.1088/0967-3334/28/11/002

DO - 10.1088/0967-3334/28/11/002

M3 - Article

C2 - 17978419

AN - SCOPUS:35848940283

VL - 28

SP - 1341

EP - 1353

JO - Physiological Measurement

JF - Physiological Measurement

SN - 0967-3334

IS - 11

ER -