Consensus guidelines for the treatment of atopic dermatitis in Korea (part II)

Systemic treatment

Jung Eun Kim, Hyun Jeong Kim, Bark Lynn Lew, Kyung Ho Lee, Seung Phil Hong, Yong Hyun Jang, Kui Young Park, Seong Jun Seo, Jung Min Bae, Eung Ho Choi, Ki Beom Suhr, Seung Chul Lee, Hyun Chang Ko, Young Lip Park, Sang Wook Son, Young Jun Seo, Yang Won Lee, Sang Hyun Cho, Chun Wook Park, Joo Young Roh

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Background: Since the treatment guidelines for atopic dermatitis (AD) were issued by the Korean Atopic Dermatitis Association (KADA) work group in 2006, there have been further advances in the systemic treatment of AD. Objective: We aimed to establish updated evidence- and experience- based systemic treatment guidelines for Korean AD. Methods: We compiled a database of references from relevant systematic reviews and guidelines regarding the systemic management of AD, including antihistamines, antimicrobials, systemic immunomodulators, allergen-specific immunotherapy, phototherapy, adjunctive treatment, and complementary and alternative medicines. Evidence for each statement was graded and classified based on the strength of the recommendation. Thirty-nine council members of KADA participated in the three rounds of votes and expert consensus recommendations were established. Results: The use of antihistamines is recommended to relieve pruritus and to prevent exacerbation due to scratching in AD patients. Infection should be controlled as needed and long-term medication should be avoided. For moderate to severe AD patients, concomitant active treatments with systemic immunomodulators are indicated. Cyclosporine is the first choice among systemic immunomodulators and others should be considered as second-line alternatives. Allergen- specific immunotherapy could be effective in AD patients with aeroallergen hypersensitivity. Phototherapy can be useful for moderate to severe AD patients and narrowband ultraviolet B is the most effective option. Complementary and alternative medicines cannot be recommended for treating AD. Conclusion: We expect these recommendations to be a reference guide for physicians and AD patients in choosing the appropriate treatment to improve quality of life and decrease unnecessary social medical costs.

Original languageEnglish
Pages (from-to)578-592
Number of pages15
JournalAnnals of Dermatology
Volume27
Issue number5
DOIs
Publication statusPublished - 2015 Oct 1

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Atopic Dermatitis
Korea
Guidelines
Complementary Therapies
Immunologic Factors
Therapeutics
Immunologic Desensitization
Phototherapy
Histamine Antagonists
Pruritus
Cyclosporine
Hypersensitivity
Quality of Life
Databases
Physicians
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Kim, J. E., Kim, H. J., Lew, B. L., Lee, K. H., Hong, S. P., Jang, Y. H., ... Roh, J. Y. (2015). Consensus guidelines for the treatment of atopic dermatitis in Korea (part II): Systemic treatment. Annals of Dermatology, 27(5), 578-592. https://doi.org/10.5021/ad.2015.27.5.578
Kim, Jung Eun ; Kim, Hyun Jeong ; Lew, Bark Lynn ; Lee, Kyung Ho ; Hong, Seung Phil ; Jang, Yong Hyun ; Park, Kui Young ; Seo, Seong Jun ; Bae, Jung Min ; Choi, Eung Ho ; Suhr, Ki Beom ; Lee, Seung Chul ; Ko, Hyun Chang ; Park, Young Lip ; Son, Sang Wook ; Seo, Young Jun ; Lee, Yang Won ; Cho, Sang Hyun ; Park, Chun Wook ; Roh, Joo Young. / Consensus guidelines for the treatment of atopic dermatitis in Korea (part II) : Systemic treatment. In: Annals of Dermatology. 2015 ; Vol. 27, No. 5. pp. 578-592.
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title = "Consensus guidelines for the treatment of atopic dermatitis in Korea (part II): Systemic treatment",
abstract = "Background: Since the treatment guidelines for atopic dermatitis (AD) were issued by the Korean Atopic Dermatitis Association (KADA) work group in 2006, there have been further advances in the systemic treatment of AD. Objective: We aimed to establish updated evidence- and experience- based systemic treatment guidelines for Korean AD. Methods: We compiled a database of references from relevant systematic reviews and guidelines regarding the systemic management of AD, including antihistamines, antimicrobials, systemic immunomodulators, allergen-specific immunotherapy, phototherapy, adjunctive treatment, and complementary and alternative medicines. Evidence for each statement was graded and classified based on the strength of the recommendation. Thirty-nine council members of KADA participated in the three rounds of votes and expert consensus recommendations were established. Results: The use of antihistamines is recommended to relieve pruritus and to prevent exacerbation due to scratching in AD patients. Infection should be controlled as needed and long-term medication should be avoided. For moderate to severe AD patients, concomitant active treatments with systemic immunomodulators are indicated. Cyclosporine is the first choice among systemic immunomodulators and others should be considered as second-line alternatives. Allergen- specific immunotherapy could be effective in AD patients with aeroallergen hypersensitivity. Phototherapy can be useful for moderate to severe AD patients and narrowband ultraviolet B is the most effective option. Complementary and alternative medicines cannot be recommended for treating AD. Conclusion: We expect these recommendations to be a reference guide for physicians and AD patients in choosing the appropriate treatment to improve quality of life and decrease unnecessary social medical costs.",
author = "Kim, {Jung Eun} and Kim, {Hyun Jeong} and Lew, {Bark Lynn} and Lee, {Kyung Ho} and Hong, {Seung Phil} and Jang, {Yong Hyun} and Park, {Kui Young} and Seo, {Seong Jun} and Bae, {Jung Min} and Choi, {Eung Ho} and Suhr, {Ki Beom} and Lee, {Seung Chul} and Ko, {Hyun Chang} and Park, {Young Lip} and Son, {Sang Wook} and Seo, {Young Jun} and Lee, {Yang Won} and Cho, {Sang Hyun} and Park, {Chun Wook} and Roh, {Joo Young}",
year = "2015",
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language = "English",
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Kim, JE, Kim, HJ, Lew, BL, Lee, KH, Hong, SP, Jang, YH, Park, KY, Seo, SJ, Bae, JM, Choi, EH, Suhr, KB, Lee, SC, Ko, HC, Park, YL, Son, SW, Seo, YJ, Lee, YW, Cho, SH, Park, CW & Roh, JY 2015, 'Consensus guidelines for the treatment of atopic dermatitis in Korea (part II): Systemic treatment', Annals of Dermatology, vol. 27, no. 5, pp. 578-592. https://doi.org/10.5021/ad.2015.27.5.578

Consensus guidelines for the treatment of atopic dermatitis in Korea (part II) : Systemic treatment. / Kim, Jung Eun; Kim, Hyun Jeong; Lew, Bark Lynn; Lee, Kyung Ho; Hong, Seung Phil; Jang, Yong Hyun; Park, Kui Young; Seo, Seong Jun; Bae, Jung Min; Choi, Eung Ho; Suhr, Ki Beom; Lee, Seung Chul; Ko, Hyun Chang; Park, Young Lip; Son, Sang Wook; Seo, Young Jun; Lee, Yang Won; Cho, Sang Hyun; Park, Chun Wook; Roh, Joo Young.

In: Annals of Dermatology, Vol. 27, No. 5, 01.10.2015, p. 578-592.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Consensus guidelines for the treatment of atopic dermatitis in Korea (part II)

T2 - Systemic treatment

AU - Kim, Jung Eun

AU - Kim, Hyun Jeong

AU - Lew, Bark Lynn

AU - Lee, Kyung Ho

AU - Hong, Seung Phil

AU - Jang, Yong Hyun

AU - Park, Kui Young

AU - Seo, Seong Jun

AU - Bae, Jung Min

AU - Choi, Eung Ho

AU - Suhr, Ki Beom

AU - Lee, Seung Chul

AU - Ko, Hyun Chang

AU - Park, Young Lip

AU - Son, Sang Wook

AU - Seo, Young Jun

AU - Lee, Yang Won

AU - Cho, Sang Hyun

AU - Park, Chun Wook

AU - Roh, Joo Young

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Background: Since the treatment guidelines for atopic dermatitis (AD) were issued by the Korean Atopic Dermatitis Association (KADA) work group in 2006, there have been further advances in the systemic treatment of AD. Objective: We aimed to establish updated evidence- and experience- based systemic treatment guidelines for Korean AD. Methods: We compiled a database of references from relevant systematic reviews and guidelines regarding the systemic management of AD, including antihistamines, antimicrobials, systemic immunomodulators, allergen-specific immunotherapy, phototherapy, adjunctive treatment, and complementary and alternative medicines. Evidence for each statement was graded and classified based on the strength of the recommendation. Thirty-nine council members of KADA participated in the three rounds of votes and expert consensus recommendations were established. Results: The use of antihistamines is recommended to relieve pruritus and to prevent exacerbation due to scratching in AD patients. Infection should be controlled as needed and long-term medication should be avoided. For moderate to severe AD patients, concomitant active treatments with systemic immunomodulators are indicated. Cyclosporine is the first choice among systemic immunomodulators and others should be considered as second-line alternatives. Allergen- specific immunotherapy could be effective in AD patients with aeroallergen hypersensitivity. Phototherapy can be useful for moderate to severe AD patients and narrowband ultraviolet B is the most effective option. Complementary and alternative medicines cannot be recommended for treating AD. Conclusion: We expect these recommendations to be a reference guide for physicians and AD patients in choosing the appropriate treatment to improve quality of life and decrease unnecessary social medical costs.

AB - Background: Since the treatment guidelines for atopic dermatitis (AD) were issued by the Korean Atopic Dermatitis Association (KADA) work group in 2006, there have been further advances in the systemic treatment of AD. Objective: We aimed to establish updated evidence- and experience- based systemic treatment guidelines for Korean AD. Methods: We compiled a database of references from relevant systematic reviews and guidelines regarding the systemic management of AD, including antihistamines, antimicrobials, systemic immunomodulators, allergen-specific immunotherapy, phototherapy, adjunctive treatment, and complementary and alternative medicines. Evidence for each statement was graded and classified based on the strength of the recommendation. Thirty-nine council members of KADA participated in the three rounds of votes and expert consensus recommendations were established. Results: The use of antihistamines is recommended to relieve pruritus and to prevent exacerbation due to scratching in AD patients. Infection should be controlled as needed and long-term medication should be avoided. For moderate to severe AD patients, concomitant active treatments with systemic immunomodulators are indicated. Cyclosporine is the first choice among systemic immunomodulators and others should be considered as second-line alternatives. Allergen- specific immunotherapy could be effective in AD patients with aeroallergen hypersensitivity. Phototherapy can be useful for moderate to severe AD patients and narrowband ultraviolet B is the most effective option. Complementary and alternative medicines cannot be recommended for treating AD. Conclusion: We expect these recommendations to be a reference guide for physicians and AD patients in choosing the appropriate treatment to improve quality of life and decrease unnecessary social medical costs.

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DO - 10.5021/ad.2015.27.5.578

M3 - Review article

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JO - Annals of Dermatology

JF - Annals of Dermatology

SN - 1013-9087

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